First-Class Publications from Verlag Helvetica Chimica Acta - VERLAG HELVETICA CHIMICA ACTA
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First-Class Publications from Verlag Helvetica Chimica Acta VERLAG HELVETICA CHIMICA ACTA
Part 1 examines the chemically relevant aspects by
means of carefully selected examples. After a structural
classification, structure elucidation (including common
Organic Chemistry / pitfalls) is discussed. Moreover, chiroptical properties
Organische Chemie and synthetic pathways are detailed.
Part 2 is devoted to biological and biochemical aspects.
It rationalizes chemotaxonomy and biogenesis by means
of examples (indole and 1-benzyl isoquinoline alkaloids)
and presents details about the functionality of several
alkaloids produced by plants and animals.
Part 3 finally describes the cultural and historical signi-
ficance of the most important alkaloid sources. Exciting
anecdotes and historical reports illuminate the use of
hemlock, ergot, opium, tobacco, coffee, and cinchona, to M. Volkan Kisakürek / Edgar Heilbronner (Eds.)
name only a few.
The unique and comprehensive explanation of the most Highlights of Chemistry
important features of alkaloids makes this book a com- as Mirrored in Helvetica Chimica Acta
pendium valuable not only for experts but also for the 1994. 992 pages with 996 figures. Hardcover.
layman interested in pharmacy. ¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-527-29238-1
This book provides a comprehensive overview of more
Philip Kraft / Karl A. D. Swift
than 75 years of Swiss chemical research. Leading aut-
Perspectives in Flavor and deutsche Ausgabe: hors, among them L. M. Venanzi, H. Zollinger, E. Heil-
Fragrance Chemistry Manfred Hesse bronner, and J. D. Dunitz, highlight outstanding pieces
2005. 230 pages. Hardcover.
of research that have appeared in Helvetica Chimica
¤ 129.00/SFr 190.00/GBP 90.00/US$ 170.00. ISBN 3-906390-36-5
Alkaloide Acta since its foundation in 1917.
Fluch oder Segen der Natur?
From the smell of a rich and sensual musky perfume to
2000. 432 Seiten mit 186 Abbildungen und 14 Tabellen. Gebunden.
the taste sensation imparted by the finest of wines, the ¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-906390-19-5
senses of smell and taste are fundamental to all of us.
This book is a compilation of 18 of the 24 talks presented
at the 2004 RSC–SCI Flavors and Fragrances conference
at the Manchester Conference Center. The meeting was
spaced over two and a half days and saw speakers and
delegates from all corners of the world exchanging ideas
and information. The aim was to bring together scientists
from both industry and the academic world, who have a
common interest in flavors and fragrances. The subject
matter was intentionally broad, including natural prod-
ucts, fragrance chemistry, perfumery, and olfaction, as
well as foods and flavors. Chemistry was the central dis-
cipline and served as the common strand for the meeting. Hans-Georg W. Leuenberger / Bertraud Nagel /
Heinz Kölbl (Eds.)
M. Volkan Kisakürek (Ed.)
A Multilingual Glossary of
Biotechnological Terms
Hominatio IUPAC Recommendations
An International Tribute to Albert Eschenmoser 1995. 251 pages. Hardcover.
2001. 996 pages. Hardcover. ¤ 42.90/SFr 64.00/GBP 29.95/US$ 55.00. ISBN 3-906390-13-6
¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00. ISBN 3-906390-27-6
This volume contains IUPAC-approved definitions of
Few individuals have so fundamentally influenced the over 230 terms most frequently used in the multidiscipli-
science of organic chemistry as Albert Eschenmoser. In nary field of biotechnology, together with their transla-
addition to revealing the beautiful reaction pathways tion into six further languages, namely French, German,
leading to compounds of great biochemical significance, Japanese, Portuguese, Russian, and Spanish. The terms
Albert Eschenmoser has contributed innovative are presented in dictionary format for easy look-up. The
methods of outstanding utility for organic synthesis. aim is to facilitate communication between chemists,
Manfred Hesse Over the years, a sizable fraction of Albert Eschenmo- chemical engineers, biologists, and bioengineers, and to
ser's work has been published in Helvetica Chimica render biotechnology more accessible to the chemical
Alkaloids Acta, hence the Editor's decision to produce a special profession. The scope of this work includes the fields of
Nature's Curse or Blessing? issue of the journal on the occasion of Albert Eschenmo- microbiology, genetic engineering, biochemistry, molec-
2002. 414 pages with 185 figures, 110 in color. Hardcover. ser's 75th birthday. The highly impressive set of 67 origi- ular biology, biochemical engineering, bioprocessing,
¤ 129.00/SFr 190.00/GBP 90.00/US$ 160.00. ISBN 3-906390-24-1 nal research papers submitted in response to the Edi- general concepts of biotechnology making this compila-
tor's invitation were divided over the August and Sep- tion and indispensable reference.
This is the first comprehensive reference work providing tember issues. The international reaction to this tribute
a concise overview of structure, properties, and history has been so overwhelmingly enthusiastic that the two
of these unique and fascinating substances! The volume issues have now been combined in this single volume.
is organized into three main sections:ern interdisciplinary concept between chemistry and
biology – an approach that proved to be useful in univer-
sity education. A unique book, important for both lectur-
ers and students. General Chemistry /
Allgemeine Chemie / Sachbuch
Jack D. Dunitz
X-Ray Analysis and the Structure
of Organic Molecules
2nd edition
1995. 514 pages with 197 figures and 30 tables. Hardcover.
¤ 65.00/SFr 96.00/GBP 45.00/US$ 81.00. ISBN 3-906390-14-4 Gerhard Quinkert / Ernst Egert / Christian Griesinger
Ahmed Zewail
This is the second corrected reprint of 'X-Ray Analysis', Aspekte der Organischen Chemie
published in 1979, and consists of two parts. Part one Struktur Reise durch die Zeit –
deals with crystal structure analysis, while the second
1995. 503 Seiten mit 262 Abbildungen und 79 Tabellen. Gebunden.
Weg zum Nobel-Preis
part deals with molecular structure. All the information ¤ 89.00/SFr 131.00/GBP 65.00/US$ 148.00. ISBN 3-906390-11-X 2005. 321 Seiten. 150 Farbabbildungen. Gebunden.
is of considerable value, especially to those working in, ¤ 49.00/SFr 73.00/GBP 34.95/US$ 42.95. ISBN 3-906390-32-2
or about to embark upon X-ray crystal structure analysis. In diesem Buch wird die chemische Struktur so vielseitig Erscheinungstermin: ca. August 2005
wie nie zuvor behandelt. Die Auswahl der detailliert
beschriebenen Moleküle und Übermoleküle entspricht Ahmed Zewail erzählt sein Leben und führt gleichzeitig
dem Anliegen der renommierten Autoren, Grenzüber- durch die extrem kurzlebige Welt der Moleküle. Von
Beat Ernst / Christian Leumann (Eds.)
schreitungen zwischen Chemie und Biologie zur Selbst- einer ägyptischen Stadt im Nildelta und dem Hafen von
Modern Synthetic Methods 1995 verständlichkeit zu verhelfen. Alexandria bis zu den malerischen Landschaften Südka-
liforniens führt der Weg. Fesselnd erzählt der Forscher
1995. 464 pages with 200 figures, 49 in color. Hardcover.
¤ 75.00/SFr 111.00/GBP 55.00/US$ 94.00. ISBN 3-906390-12-8 von seinen Erlebnissen und seiner Arbeit bis zur Verlei-
hung des Nobelpreises 1999; allgemein verständlich
This collection of the six contributions at the 7th Interna- erklärt er die Beobachtung von Molekülen im Zeitmaß-
tional Seminar on Modern Synthetic Methods, written stab von Femtosekunden.
by leading experts in their fields, provides an overview Aus seinem bisherigen Leben zieht der Autor Lehren, und
of the state of the art, trends, and new accomplishments er denkt über den Einfluss des wissenschaftlichen Fort-
in solvent effects on chemical transformations, in reac- schritts auf die Gesellschaft nach. Den Besitzlosen erteilt
tions on surfaces, in the synthesis of oligosaccharides er konkrete Ratschläge zum Handeln. Am Ende des
and nucleid acid analogues, and in antibody catalysis. Buches spricht er die Hoffnung aus, Ägypten möge sich
An invaluable companion to both active research chem- auf die junge Generation – seinen größten Naturschatz –
ists and advanced students, fascinated by the world of besinnen und Amerika möge neue Visionen der Innen-
biologically important compounds and by the creativity in und Außenpolitik hervorbringen.
synthetic techniques directed towards their preparation. Ein Buch für den allgemein interessierten und den natur-
wissenschaftlich ambitionierten Leser.
Albert Gossauer
Struktur und Reaktivität der
Biomoleküle
Eine Einführung in die Organische Chemie
2005. ca. 550 Seiten. Softcover.
ca. ¤ 98.00/SFr 145.00. ISBN 3-906390-29-2
Erscheinungstermin: ca. September 2005
Dieses Lehrbuch behandelt den für einen Grundkurs in
organischer Chemie an der Universität üblichen Stoff auf
eine neue Weise und fördert so die Kommunikation zwi-
schen Chemikern und Biologen. Darin werden anhand
zahlreicher Beispiele die Struktur und Reaktivität organi-
Gerhard Quinkert / Ernst Egert / Christian Griesinger scher Moleküle sowie die Mechanismen einfacher Reak-
tionen der organischen Chemie erläutert, die in biologi-
Günther Ohloff
Aspects of Organic Chemistry schen Prozessen relevant sind. Damit im Zusammenhang
Structure stehende biologisch relevante Stoffe und enzymatische Düfte – Signale der Gefühlswelt
1996. 506 pages with 262 figures and 79 tables. Hardcover. Reaktionen stellen dann den Bezug zur Biologie her. 2004. 321 Seiten mit 150 Farbabbildungen. Gebunden.
¤ 85.00/SFr 125.00/GBP 60.00/US$ 105.00. ISBN 3-906390-15-2 Zudem wird anhand von mehr als 100 Lebenswerken ¤ 98.00/SFr 145.00/GBP 70.00/US$ 140.00. ISBN 3-906390-30-6
berühmter Wissenschaftler die geschichtlichen Zusam-
This book focuses on molecular structure, especially menhänge aufgezeichnet, die das 20. Jahrhundert als Die Macht der Gerüche ergriff Dichter und Denker aller
that of nucleid acids and proteins. The author team of die Epoche der großen Errungenschaften in der moder- Zeiten. Sie dienten besonders den französischen Schrift-
internationally recognized specialists presents a mod- nen Chemie und Physik charakterisieren.stellern des 19. Jahrhunderts als wesentliche Quelle der • chiral auxiliaries in organic synthesis
Inspiration, lange bevor sich die Psychologie und Neuro- • photochemistry in natural product synthesis
wissenschaften mit der seelischen Auswirkung der • innovations in combinatorial synthesis approaches
Gerüche auseinandergesetzt hatten. • molecular recognition
Der prominente Duftstoffchemiker Günther Ohloff (Irdi- • modulation of molecular function
sche Düfte – Himmlische Lust, eine Kulturgeschichte der These are rounded off with a note on how the frontiers
Duftstoffe) diskutiert, wofür Düfte verantwortlich sind, of medical ethics may be breached by molecular manip-
was sie mit uns machen. Er veranschaulicht außerdem, ulations.
in welcher Beziehung Geruch, Erinnerung und Emotio- The contributors, who number among the finest scien-
nen zueinander stehen. tists in the world, including two Nobel Prize winners, are
Auch die Forschung der Nobelpreisträger 2004 für Medi- Peter B. Dervan, Jack D. Dunitz, Christian Griesinger,
zin, Linda Buck und Richard Axel, die für die Verdienste Jean-Marie Lehn, Thomas F. Prisner, Gerhard Quinkert,
um die Erklärung des Geruchssinns geehrt wurden, wird Peter G. Schultz, Helmut Schwarz, Dieter Seebach, and
in diesem Buch beschrieben. Ahmed Zewail with a prologue by Albert Eschenmoser, Edgar Heilbronner / Jack D. Dunitz
Ein Buch mit 150 Farbabbildungen für Parfumliebhaber, for whom this collection was conceived.
Literaten und solche, die mehr erfahren wollen über den Reflections on Symmetry
«unbewußten» Sinn des Menschen. In Chemistry... and Elsewhere
1992. 160 pages with 125 figures and 4 tables. Hardcover.
¤ 37.90/SFr 57.00/GBP 27.50/US$ 47.00. ISBN 3-527-28488-5
IN PREPARATION:
A fascinating book on a fascinating topic. This is a highly
readable introduction to symmetry in art and science.
Roman Kaiser Lucidly written and beautifully illustrated, this book pro-
Meaningful Scents vides an eminently readable discussion of the omnipres-
around the World ent concept of symmetry, its application in all branches
of science, and its perception in nature, art and else-
2005. ca. 250 pages. Hardcover.
where.
ca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50. ISBN 3-906390-37-3
Due: November 2005
Günther Ohloff
Bernhard Lippert (Ed.)
Earthly Scents – Heavenly Pleasures
A Cultural History of Scents Cisplatin
2006. ca. 300 pages. Hardcover.
Chemistry and Biochemistry of a Leading Anticancer Drug
ca. ¤ 49.90/SFr 75.00/GBP 34.95/US$ 43.50. ISBN 3-906390-34-9 1999. 576 pages with 146 figures and 34 tables. Hardcover.
Due: ca. January 2006 ¤ 169.00/SFr 250.00/GBP 120.00/US$ 210.00. ISBN 3-906390-20-9
What the reviews have to say:
The discovery of Cisplatin has inspired many scientists
from diverse backgrounds and this is demonstrated
throughout the many excellent reviews. Bernhard Lip-
pert is to be congratulated on producing a book consis-
ting not only of numerous scientific articles of high Edgar Heilbronner / Foil A.Miller
quality describing current research, but also a book that
conveys the essence of scientific research. This book is A Philatelic Ramble through
recommended to all those with an interest in platinium Chemistry
chemistry, bioinorganic chemistry, biochemistry, and the 2003. 278 pages with 1025 figures. Softcover.
clinical development of platinum anticancer drugs, and ¤ 79.00/SFr 116.00/GBP 55.00/US$ 105.00. ISBN 3-906390-31-4
is a good illustration of their significance. 1998. 278 pages with 1025 figures. Hardcover.
Platinum Metals Review ¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00. ISBN 3-906390-17-9
This book does not present a guide on ‘how to build the This is not a history of chemistry using stamps instead of
Gerhard Quinkert / M. Volkan Kisakürek (Eds.) best antiocancer drug ever’… In almost all other the usual illustrations, but a collection of short essays
respects, however, it is an excellent investment and a and comments on such chemistry as can be found on
Essays in Contemporary Chemistry great pleasure to read. One needs to spend a very long postage stamps and other philatelic items. The choice of
From Molecular Structure towards Biology topics is thus dictated by the philatelic material availa-
time in the library and copy a great number of original
2001. 471 pages with 230 figures, 116 in color. Hardcover. papers to get a similar outstandning overview of a topi- ble, such that readers will find detailed comments on
¤ 149.00/SFr 220.00/GBP 105.00/US$ 185.00. ISBN 3-906390-28-4 cal area of chemistry. such lesser-known chemists as Wilhelm August Lampa-
In this volume, internationally renowned chemists re- Angewandte Chemie International Edition dius who has been honored with two stamps by the Ger-
count their roles in the progress of chemistry research man Post Office, but hardly anything on such luminaries
towards the elucidation of biological processes. Begin- as Robert Bunsen, who have yet to be deemed worthy of
ning with a historical perspective on the development of Hanns Fischer (Ed.) a commemorative issue.
X-ray crystallography, the reader is regaled with first-
hand accounts of research milestones, including
Praktikum in Allgemeiner Chemie
Teil 2: Organische und Physikalische Chemie
• nuclear-magnetic-resonance techniques
• electron-paramagnetic-resonance spectroscopic zweite Auflage
techniques 1995. 250 Seiten mit 33 Abbildungen. Spiralbindung
• the dynamics of ultra-fast reactions ¤ 27.90/SFr 42.00/GBP 19.99/US$ 48.00. ISBN 3-906390-10-1
• the central problem of molecular oxygen activation
in biological processesand the inorganic, 'dead', world. There are neuroscien-
tists, psychologists and ophthalmologists, who study the
sensation of color vision and the processing of color
Color Chemistry / stimuli in the eye and the brain. Physicists and chemists
Farbstoffchemie investigate color science, i.e., the various causes of
color. Interior designers know how the colors of furniture
and textiles can influence our condition. In all cultures,
colors play a central role due to their symbolic content.
All languages have special terms to describe colors and
colorfulness. Visual artists play with colors to reflect the
world, perhaps to alienate it, and to give us an idea of their
personal point of view. Many other examples of the influ-
ence of colors on our daily life, our culture could be found...
Heinrich Zollinger This fascinating book, written in a style that is under-
standable for interested lay readers, deals with all the
Color Chemistry varied facets of this subject.
Syntheses, Properties, and Applications of Organic Dyes
and Pigments
3rd edition
2003. 647 pages with 56 figures and 23 tables. Hardcover.
Pharmaceutical
Heinrich Zollinger ¤ 179.00/SFr 264.00/GBP 125.00/US$ 235.00. ISBN 3-906390-23-3 and Medicinal Chemistry /
Farbe This new edition of the classical text has been thor-
Pharmazeutische
Eine multidisziplinäre Betrachtung oughly updated and rewritten. Special attention is given
und Medizinische Chemie
2005. ca. 300 Seiten, ca. 70 Abbildungen. Softcover. to those topic areas that have undergone the most
ca. ¤ 98.00/SFr 145.00/GBP 70.00/US$ 85.50. ISBN 3-906390-33-0 research activity and industrial development since publi-
Erscheinungstermin: ca. August 2005 cation of the second edition. An extensive new section
devoted to synthetic polyenes developed during the last
Die Welt der Farben – wen zieht sie nicht an, wen faszi-
decade that have shown promising electrooptical proper-
niert oder verblüfft sie nicht? Zunächst natürlich Maler,
ties has been added, while the chapter on aza[18]annule-
aber auch Biologen und Mineralogen, die sich für die
nes has been expanded to include improved and sophisti-
Farbe der lebendigen und der anorganischen, der
cated synthetic approaches to the phthalocyanines and
«toten» Welt interessieren, oder Neurowissenschaftler,
porphyrins, as well as the application of these com-
Psychologen und Ophthalmologen, die sich mit dem Vor-
pounds in functional dyes and pigments. Research and
gang der Farbempfindung und der Verarbeitung von
development activities in the discovery of new dyes for
Farbstimuli im Auge und im Gehirn beschäftigen. Physi-
coloration is described in the sections on dispersed, reac-
ker und Chemiker widmen sich der Farblehre – sie unter-
tive, and sulfur dyes, as well as in new chapters covering
suchen, wie Farben entstehen.
carbonyl and the diketopyrrolo-pyrrole (DPP) family of
In allen Kulturkreisen der Welt kommt der Farbe durch
pigments. In addition, it contains a first review of the P. Heinrich Stahl / Camille G. Wermuth (Eds.)
ihren Symbolcharakter zentrale Bedeutung zu. Die Spra-
limited number of published investigations of black
che kennt spezielle Begriffe, um Farben und Farbigkeit
colorants. With its many changes and additions, this Pharmaceutical Salts
zu bezeichnen. Und so ließen sich weitere Beispiele fin- Properties, Selection, and Use
third edition is a significantly expanded successor to the
den, die den Einfluß der Farben auf unser tägliches
highly successful predecessor, and is destined to become 2002. 388 pages. Hardcover.
Leben, unsere Kultur bezeugen... ¤ 149.00/SFr 220.00/GBP 105.00/US$ 185.00. ISBN 3-906390-26-8
a classical reference work consulted by researchers in
Nicht alle Aspekte des Phänomens «Farbe» sind durch
this exciting and important subdiscipline of chemistry.
die «exakte» Wissenschaft erklärbar. Dieses faszinie- About half of all drugs used in medicine are adminis-
rende Buch widmet sich den vielfältigen Facetten des tered as salts, and the formation and the selection of a
Themas in einer auch für interessierte Laien verständli- suitable salt for a drug candidate is an essential step in
chen Weise. the preclinical phase of drug development.
In this first comprehensive resource to address the prep-
aration, selection, and use of pharmaceutically active
salts, an international team of seventeen authors from
academia and pharmaceutical industry present the
necessary theoretical foundations as well as a wealth of
detailed practical experience in the choice of pharma-
ceutically active salts.
Altogether, the contributions reflect the multidisciplinary
nature of the science involved in selection of suitable salt
forms for new drug products. The editors have taken care
to address every conceivable aspect of the preparation of
pharmaceutical salts. This book is destined to be an
Heinrich Zollinger
essential reference for students of medicinal and phar-
Color maceutical chemistry, and an indispensable handbook for
A Multidisciplinary Approach R&D chemists, analytical chemists, biologists, develop-
ment pharmacists, regulatory and patent specialists, and
1999. 268 pages with 78 figures. Hardcover.
¤ 119.00/SFr 176.00/GBP 85.00/US$ 149.00. ISBN 3-906390-18-7
medicinal scientists engaged in preclinical development
of drugs. A comprehensive up-to-date guide for all scien-
Who is not attracted, fascinated or even amazed by the tists involved in research and development of drugs and,
world of colors? Painters of course, but also biologists in particular, of pharmaceutical dosage forms.
and mineralogists are interested in colors of the livingperts from academia and industry offer state-of-the-art An account of current strategies used in computer-assis-
presentations of concepts, methods, and technologies ted drug design. Important topics include progress in
now in use or development in drug research. chemometrics, molecular modeling and three-dimension-
In addition to its 28 chapters, the book includes a CD- al QSAR approaches. As is amply illustrated, important
ROM containing the invited lectures, oral communica- progress has been made in lead finding strategies,
tions, and posters (in full version) presented at the Third which is of great importance to the pharmaceutical
LogP Symposium, 'Physicochemical and Biological Profil- industry.
ing in Drug Research', held at the Federal Institute of
Technology (ETH) of Zürich in March 2004.
M. Volkan Kisakürek / Helmut Rosemeyer (Eds.)
Perspectives in Nucleoside and
Nucleic Acid Chemistry
2000. 430 pages. Hardcover.
¤ 139.00/SFr 205.00/GBP 100/US$ 174.00. ISBN 3-906390-21-7
Many of the most important recent advances in medici-
nal chemistry have occured in this field with the develop-
ment of novel nucleoside- and nucleotide-based antiviral
Bernard Testa / Joachim M. Mayer
and antitumor drugs. New synthesis strategies involving
novel protecting groups have helped spur progress in
Bernard Testa, Han van Waterbeemd, Gerd Folkers,
Hydrolysis in Drug and Prodrug
drug-development and genome-sequencing research.
Richard Guy (Eds.)
Metabolism
This volume, comprised of contributions by internation- Chemistry, Biochemistry, and Enzymology
ally recognized experts, covers the latest developments Pharmacokinetic Optimization 2003. 780 pages. Hardcover.
in current nucleoside and nucleic acid research, including in Drug Research ¤ 159.00/SFr 235.00/GBP 115.00/US$ 210.00. ISBN 3-906390-25-X
• combinatorial approaches Biological, Physicochemical, and Computational Strategies
• spectroscopy and structural studies In this volume, Bernard Testa and Joachim M. Mayer
2001. 668 pages with 228 figures and 59 tables. Hardcover. discuss the molecular and biochemical aspects of meta-
• thermodynamic and computational investigations
¤ 169.00/SFr 250.00/GBP 120.00/US$ 220.00. ISBN 3-906390-22-5
• stability assessments, and bolic reactions of hydrolysis and hydration. While an
• medicinal applications. incl. CD-ROM encyclopedic treatment is avoided, the topics covered
The optimization of pharmacokinetic properties has include
Synthetic, physical, organic, bioorganic, and medicinal
become the bottleneck and a major challenge in drug • biochemical properties of the enzymes/isozymes
chemists working on all aspects of nucleoside and
research. There was thus an urgent need for a book • drug–enzyme interactions
nucleic acid research will value this comprehensive
covering this field in an authoritative, comprehensive, • the various chemical reactions catalyzed by enzymes
state-of-the-art overview.
factual, and conceptual manner. • reaction mechanisms and catalytic cycles
In addition to its 33 chapters, the book includes a CD-ROM • regio- and stereoselectivities
containing the invited lectures, oral communications and • structure–metabolism relationships
posters (in full version) presented at the Second LogP • molecular aspects of toxification and detoxification,
Symposium, 'Lipophilicity in Drug Disposition – Practical as well as
and Computational Approaches to Molecular Properties • enzyme inhibition.
Related to Drug Permeation, Disposition and Metab- The classification of materials is based mainly on the
olism', held at the University of Lausanne in March 2000. types of target groups and compounds being transfor-
med, with carefully selected examples to illustrate the
reactions under discussion. This approach has heuristic
value since it allows readers to make educated guesses
on the metabolism of other or novel drugs.
Bernard Testa, Stefanie D. Krämer,
Heidi Wunderli-Allensbach, Gerd Folkers (Eds.)
Pharmacokinetic Profiling
in Drug Research
Biological, Physicochemical, and Computational Strategies
2005. ca. 400 pages. Hardcover.
ca. ¤ 159.00/SFr 235.00/GBP 115.00/US$ 195.00. Han van de Waterbeemd / Bernard Testa /
ISBN 3-906390-35-7 / Due: December 2005
Gerd Folkers (Eds.)
incl. CD-ROM
Computer-Assisted Lead Finding
The profiling of ADME properties (absorption, distribu- and Optimization
tion, metabolism, and excretion) is the focus of this book. Current Tools for Medicinal Chemistry
Many major advances have been made during the last
1997. 566 pages with 232 figures, 51 in color, and 57 tables. Hardcover.
years in biological, physicochemical, or computational
¤ 139.00/SFr 205.00/GBP 100.00/US$ 174.00. ISBN 3-906390-16-0
strategies. International authorities and practicing ex-Excellent Journals
try
Chemis
Pro g
bin
Nature
Helvetica Chimica Acta Chemistry & Biodiversity Both journals are available online through Wiley
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Helvetica Chimica Acta
Chemistry & Biodiversity
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