Produktübersicht Synthese & Chromatographie - Ein ausgewähltes Sortiment an Labor- und Prozessgeräten samt Zubehör Zu allen Produkten bieten wir ...
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Produktübersicht
Synthese &
Chromatographie
Ein ausgewähltes Sortiment an Labor- und
Prozessgeräten samt Zubehör
Zu allen Produkten bieten wir Applikationssupport,
Beratung sowie umfangreiche
Service- und Garantieleistungen
Synthese - Chromatographie Heat-On Metall-Heizböcke Radleys Parallel Reaktionssysteme Radleys Mya 4 Reaktionssysteme Radleys Laborreaktoren - Reaktorsysteme Radleys Luftkühler Radleys Mikrowellen Synthese CEM Mikrowellenunterstützte Peptid-Synthese CEM Flash-Chromatographie Teledyne Isco Flash kombiniert mit Prep HPLC Teledyne Isco HPPLC-System - ACCQ Prep HP150 Teledyne Isco Fraktionssammler Teledyne Isco Präparatives SFC System Sepiatec Präparatives SFC System Sepiatec Parallel-Chromatographie Sepiatec Verbrauchsmaterial Chromatographie Chrom4 Autosampler für Head Space und flüssig Injektion hta
Synthese - Chromatographie
Heat-On Metall-Heizböcke
Die Alternative für verschmutzte Ölbädern und
Heizmantel. Vermeidet das Überlaufen von Heizölen und
macht somit das Arbeiten sicherer.
Heat-On-Heizblöcke eliminieren das Unfall- und Feuerrisiko im Labor
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Einfach die sicherste, schnellste und effizienteste Art für das Aufheizen und
Rühren der Rund- und Birnenkolben
Erhältlich für 10 ml bis 5000 ml Rund- und Birnenkolben
Parallel Reaktionssysteme
Grösste Auswahl an Parallelsynthese-Werkzeugen für
Forschung und Entwicklung. Kleinster Platzbedarf bei 4,
6, 12 und 24 Parallelreaktionen.
Diverse Carousels mit 6, 12 oder 24 Positionen zur parallelen Synthese oder
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Aufarbeitung
Gleichzeitiges Rückflussieren oder Kühlen von bis zu 12 Reaktionen unter
Inert- bzw. Reaktionsgas
Mya 4 Reaktionssysteme
Das Reaktionssystem mit unbegrenzten Möglichkeiten,
hervorragender Reproduzierbarkeit und Data Logging
24/7 Intergrierte Software.
4 unabhängige Zonen von -30 °C bis +180 °C
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Für Prozess und Forschung
Reaktionsvolumen von 2 mL bis 400 mL
Mit Magnet- oder Überkopfrührer
24.01.2022 Seite 1
Synthese - Chromatographie
Laborreaktoren - Reaktorsysteme
Umfangreiche Auswahl an Laborreaktoren mit und ohne
Computersteuerung. Sehr einfache Fremdgeräteadaption
von Waagen, Thermostaten, Pumpen, pH-Sonden,
Trübungsmessgeräten....
Genaue Verfolgbarkeit und Wiederholbarkeit der Experimente
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Einfache Optimierung von Reaktionen
Einfacher Reaktorwechsel ohne Werkzeuge in wenigen Sekunden
Luftkühler
Findenser, der Super Luftkühler braucht kein fliessendes
Wasser. Deshalb ist er besonders ressourcenschonend,
kosteneffizient und verhindert eine mögliche Überflutung.
Der Findenser ist in zwei Grössen, sowie mit verschiedenen Schliffgrössen
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erhältlich.
Der Findenser wird für Volumen von 5 mL - 1 L eingesetzt.
Das Antirollsystem verhindert das Weiterrollen, wenn der Findenser nicht in
Gebrauch ist.
Mikrowellen Synthese
Mit dem Discover 2.0 führen Sie Ihre organischen oder
anorganischen Synthesen im Handumdrehen erfolgreich
durch.
Reaktionsgefässe von 10ml bis 125ml
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5.0 Megapixel Kamera zum Aufnehmen von Bildern und Videos Ihrer
Reaktion
Mit dem Autosampler haben Sie Platz für bis zu 48 Vials
Der Cool Mate führt Ihre Reaktionen bei bis zu -80 °C durch
Automatische Gaszugabe oder Inertisierung möglich
24.01.2022 Seite 2
Synthese - Chromatographie
Mikrowellenunterstützte Peptid-Synthese
Immer mehr Wissenschaftler erkennen die Vorteile des
Mikrowellen - Einsatzes in der Synthese von Peptiden
sowie der Analyse von Peptiden und Proteinen. CEM
bietet dazu ein Programm mit verschiedensten Geräten
an.
Peptid - Synthese (Discover SPS, Liberty Blue)
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Peptid - Cleavage System (Accent)
Proteinhydrolyse (Discover inkl. Spezial Zubehör)
Enzymatischer Aufschluss (Discover inkl. Spezial Zubehör)
Flash-Chromatographie
Der Combiflash NextGen 300/300+ steigert die
Produktivität, ist schneller, effizienter und dank der
Gradientenoptimierung auch grüner.
Flussraten von 1-300 mL/Min. und maximal Druck von 20 Bar (300 PSI)
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Detektoren; wahlweise oder kombinierbar: UV, UV-VIS (PDA Technologie),
ELSD und MS
Scale Up System: Combifash Torrent; bis 1L/Min. Flussrate und 13.8 Bar
Druck.
Säulen: RediSep Säulen sind in verschiedenen Medien und Grössen
erhältlich, sowie auch in Qualitäten wie spährischen RediSep Gold.
Flash kombiniert mit Prep HPLC
Automatisiertes Combiflash EZ Prep, die perfekte und
einfachste Kombination von Flash und Prep HPLC
Chromatographie in dem kompaktesten System am
Markt.
Flussraten: 5-200ml/min; Drücke: Flash 13.8bar, Prep HPLC 240bar
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4 Lösungsmittel anschliessbar; binäre Gradienten bei aktiver LM-Entgasung
Aktive Fehlervermeidungsfunktionen: ua. Lösungsmitteldetektion
Benutzerfreundliche, intuitive Soft Ware: alle Parameter während Trennung
änderbar
Detektion: UV, UV-VIS, ELSD und MS (10-2000 Da; ESI und APCI)
24.01.2022 Seite 3
Synthese - Chromatographie
HPPLC-System - ACCQ Prep HP150
Das High Performance Preparative Liquid
Chromatography-System verfolgt einen ganz neuen Weg
betreffend Bedienerfreundlichkeit, Einfachheit und
Intuitivität.
Flussraten: 1 - 150 ml/Min; Druck: bis 400 bar
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Max. 6 Lösungsmittel anschliessbar; binäre Gradienten bei aktiver
Lösungsmittel-Entgasung.
Aktive Fehlervermeidungsfunktionen inkl. Lösungsmitteldetektion. Run
Parameter abänderbar on the fly.
UV,UV-Vis,ELSD und MS (10-2000 Da; ESI und APCI)
Fraktionssammler
Foxy® R1 und R2: Eine neue Generation mit erweiterter
Sammelkapazität und RFID Technologie; hervorragende
Genauigkeit bei Fraktionierung mit Peaktrennmethoden.
Zuverlässigkeit bei Fraktionierung nach Zeit, Tropfen- oder Pumpenvolumen
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Grosse Auswahl an Racks (Gestellen)
Intuitive Bedienung über Touchscreen mit Symbolen
Eingebautes Ethernet und RS-232 Komunikationsfähigkeit
Miniatur-Fraktionensammler Retriever 500: Fläche nur DIN A4!
Präparatives SFC System
Prep SFC 250 ist ein sehr kompaktes (kleinste Standfläche
auf dem Markt) und äusserst bedienerfreundliches
Preparatives SFC System mit Flussraten bis 250ml/min.
Detektion mit DAAD UV/VIs, aber auch mit MS erhältlich.
Säulen bis 30mm Durchmesser.
Schärfere Peaks und schnellere, häufig bessere Trennungen als mit HPLC
Enorme Lösungsmittelersparnis: bis zu 3 Lösungsmittel zum CO2 zur
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Trennung einsetzbar (auch EtOH)
2x 400bar pro Pumpenkopf und 8 Fraktionen (bis 1l jede) separiert mit
Cyclone-Technik zu über 95% Reinheit
Integrierter 15.6‘‘ Touch Screen mit intuitiver, einfacher Software
MS von Advion mit ESI und APCI als Ionenquelle
24.01.2022 Seite 4
Synthese - Chromatographie
Präparatives SFC System
Das Prep SFC M5 ist die "all in one" Lösung für chirale
und achirale Trennungen mittels überkritischer
Fluidchromatographie.
Inklusive integriertem Autosampler.
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Analytische, halb präparative oder präparative Säulen.
UV, ELSD und / oder MS Detektoren möglich.
Flussraten von 0.1-100ml/min bei 400 bar.
Parallel-Chromatographie
Das erste echte, parallele 8fach HPLC (bzw. SFC) System
für den Hochdurchsatz. Je 8 Flussratenregler, ein 8fach
Autosampler und 8 DAD Detektoren sorgen für
garantiert individuelle Auftrennung (keine
Kreuzkontamination möglich!) der 8 Proben.
Flussraten von 0.5ml bis 20ml/min je Einzelkanal wählbar
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Variabel einsetzbar, zur Methodenentwicklung, der Aufreinigung von
Synthesen und der Anayltik
Analytische und präparative Ausführung erhältlich
Sepbox: automatisierte Chromatographie-Systeme zur Auftrennung von
Naturstoffen
Erhebliche Steigerung des Probendurchsatzes in der Wirkstoffsuche
Verbrauchsmaterial Chromatographie
Das Sortiment von Chrom4 besteht aus hochwertigem
Chromatographie Verbrauchsmaterial zu äusserst
günstigen Preisen.
LC- und GC-Säulen: Ultrasphere spherical (3/5 µm), Partisil irregular (5/10
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µm) and Reprosil spherical (Maisch) porous silica
Proben Handling - vials, caps, inserts, 96 well Plates, sealing mats
Probenvorbereitung – Filtration, Syringe and Membrane Filters
(InnoSep/Thomson), nano Filter Vials
Dissolution-Zubehör und –Gläser
24.01.2022 Seite 5
Synthese - Chromatographie
Autosampler für Head Space und flüssig Injektion
Diverse Autosampler für Ihren GC und Ihr LC mit oder
ohne MS sowie Probenvorbereitungs-
Automatisierungssysteme.
HT3000A Series Liquid GC Autosampler vom Einsteigemodel bis zum
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Profimodell
HT2000 Series GC Autosampler "Headspace" und "all in one"
HT4000L HPLC Autosampler Lab Automation ready
HT4000E Automated SPE-HPLC Autosampler
HT4000A Automatisierung, Probenvorbereitung
24.01.2022 Seite 6
Benchtop and Hotplate Tools Control Software Findenser Heat-On Block Cool-It Insulated AVA Laboratory Control Software Air Condenser System Bowls and Data Hub Page 4 Page 5 Page 6 Page 26/27 StarFish Work Carousel Overhead Station Stirring Hotplates Stirrers Page 7 Page 8 Page 9 Parallel Reaction Stations Carousel 12 Plus Cooled Carousel 12 Carousel 6 Plus Cooled Carousel 6 Carousel Reaction Station Plus Reaction Station Reaction Station Plus Reaction Station Work-Up Station Page 10 Page 11 Page 12 Page 13 Page 19 GreenHouse Cooled GreenHouse GreenHouse GreenHouse Plus Parallel Plus Parallel Blowdown Work-Up Synthesiser Synthesiser Evaporator Station Page 16 Page 16 Page 17 Page 18 Tornado Storm Breeze Overhead Work Work Stirrer Station Station Page 14 Page 15 Page 15 Jacketed Lab Reactors Custom Jacketed Reactor-Ready Reactor-Ready Reactor-Ready Lara Controlled Reaction Lab Reactor Duo Lab Pilot Lab Lab Reactor Systems Reactor Reactor Page 21 Page 22 Page 23 Page 24 Page 25 t: +44 1799 513320 f: +44 1799 513283 e: sales@radleys.co.uk www.radleys.com 3
Mya 4 Reaction Station •
•
4 independent zones
Magnetic and overhead stirring
One reaction station with limitless possibilities • -30 °C to +180 °C
• 2 ml to 400 ml vessels
• Software control
Improving the productivity of your chemistryKey Features
A 4-zone reaction station offering safe and precise heating, active cooling,
software control and data-logging for 24/7 unattended chemistry
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• 2 ml to 400 ml
• Vials, tubes, round bottom
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• Stirs from 100 to 1000 rpm process vessels • Water-cooled
• Co
Control each position independently • Efficient refluxing
• Powerful, high torque motor • Distributes inert gas
• Tool-free attachment
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• Easily view your
• Distributes water
vessel contents
for glass condensers
• Distributes inert gas
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• High performance 7HPSHUDWXUH&WR&
insulation minimises • Independent control of each zone
zone cross-talk • Block or solution control
• Pt100 temperature probes
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• No need for a separate chiller
• Powerful Peltier technology 6SDFHVDYLQJ
provides rapid cooling • Compact benchtop footprint
• Less space than 4 separate
reaction set-ups
Magnetic stirring
from 100 to 1000 rpm
• Control each position
independently
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• Supplied as standard
• Intuitive and easy to use
• Set automated profiles
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or use manual control
• Integrate and control 3rd
party devices such as pumps,
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balances and pH sensors
• Control heating/cooling
/HW'DLV\LQWURGXFH and stirring of each zone
our Mya 4 independently
www.radleys.com/mya4
2 Radleys Shire Hill, Saffron Walden, Essex, CB11 3AZ. United Kingdom2YHUYLHZ
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to process development
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• 4 different temperature zones, each with heating and active cooling
• Use one compact system for a range of experiments
• Precise temperature control
• Magnetic or optional overhead stirring
• Accepts a wide range of vessel sizes and styles
• Control your experiments and log results automatically
• Use Mya 4 with or without a chiller
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Single or parallel synthesis
Design of Experiment (DoE)
Process development
Scale up
Route scouting
Crystallisation studies
Polymorph screening
Lead optimisation
Reaction optimisation
Reagent, catalyst and solvent screening
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• 5HSODFHLQHI¿FLHQWPHVV\DQGXQVDIHRLODQGLFHEDWKV
• Save space compared with separate reaction set-ups
• Software control improves safety, reduces manual errors, and allows 24/7
unattended chemistry, for improved productivity
• Create, repeat and share experiments and results with ease and accuracy
• Easily manage complex multi-step and multi-device experiments
• Integrate 3rd party devices such as pumps, balances and pH sensors etc.
t: +44 1799 513320 f: +44 1799 513283 e: sales@radleys.co.uk www.radleys.com 3Schnelle, einfache und sichere Arbeitsweisen mit
Mikrowellen-Laborgeräten in der Chemie, Biochemie,
Pharmazie und Life Sciences
In vielen Bereichen der Chemie, Biochemie, Pharmazie und der
Life Sciences sind langwierige und mitunter auch umweltge-
fährende Arbeitsmethoden etabliert.
Mit modernen Mikrowellen-Laborgeräten können viele dieser
traditionellen Arbeiten deutlich bescheunigt und somit effizi-
enter gestaltet werden. Zudem wird dem Gedanken des
Arbeits- und Umweltschutzes Rechnung getragen, häufig
Strom gespart und Abfälle reduziert.
So bieten sich für diese klassischen Arbeitsgebiete als Alter-
native Mikrowellen-Labormethoden an:
o Feuchte- und Feststoffgehalt, auch von
lösemittelhaltigen Proben
o Schnelle Trocknung als Alternative zum
Smart Turbo: Mikrowellen-Trockner
Vakuum-Trockenschrank
Feuchte- und Feststoffgehalte in nur 2 min. o Fett- und Ölgehalt, ohne Chemikalien
o Fett- und Ölgehalt, nasschemische Extraktion
o Mikrowellenbeschleunigte Lösemittel-Extraktion
(MASE) als Alternative zur Soxhlet-Extraktion
o Mikrowellen-Säure-Aufschluss zur Bestimmung
des Elementgehaltes
o Schneller Aschegehalt, Glühverlust, Glührückstand,
Füllstoffgehalt
o Gehalt an Sulfatasche gemäß Pharma-Normen
o Inertgas-Veraschung
o Protein-Hydrolyse zur Aminosäure-Analyse
o Enzymatischer Verdau
o Chemische und biochemische Synthese
o Peptid-Synthese
Chemische Reaktionen in der Mikrowelle mit Touch-Screen Bedienung.
CEM GmbH
Carl-Friedrich-Gauß-Str. 9 Tel.: +49 (0 )28 42 /96 44-0 Internet: www.cem.de
D-47475 Kamp-Lintfort Fax: +49 (0 )28 42 /96 44-11 E-Mail: info@cem.de®
RediSep Solid Load Cartridges ®
RediSep Library
RediSep solid load cartridges improve the resolution of the compound and eliminate reaction byproducts when compared to liquid
injection techniques. Prepare pre-filled solid load cartridges by pipetting the dissolved sample onto the top of the cartridge. Prepare
Teledyne ISCO has an extensive library of application notes, posters, and
empty solid load cartridges by filling the cartridge with a slurry mixture of the dissolved sample and supporting media. For optimal paper reprints. Some of the most requested documents are listed below.
benefits, remove the solvent by vacuum before placing the cartridge on the purification system.
Silica Detection Techniques
Empty Disposable Adjustable Solid Load Cartridge Cap (SLCC) ®
AN70, Higher Resolution Results with RediSep Gold Silica AN22, Expanded Compound Wavelength Detection with UV-Vis
Sample Load Cartridges Size Catalog # Columns
AN80, Evaporative Light Scattering Detectors
Size Qty Catalog # For use with RediSep sample load cartridges. Poster Reprint, Purification of Carbohydrates by MPLC
5g 30 69-3873-235 Fits 2.5 and 5 gram sample load cartridges. AN81, CombiFlash® All-wavelength Collection
For use on CombiFlash® systems 60-5237-047 Poster Reprint, Spherical Silica Increases Loading Capacity
25 g 30 69-3873-240 AN90, Why Use ELSD if My Compound Absorbs UV?
65 g 12 69-3873-225 Fits 12 and 25 gram sample load cartridges.
For use on all CombiFlash® and Torrent systems 60-5237-048 C18 AN93, Information Rich Flash Chromatography I Mass Directed
260 g 6 69-3873-201 Fractionation
Fits 32 and 65 gram sample load cartridges. AN49, Improvements in RP MPLC as Alternative to Prep HPLC
750 g 4 69-3873-224 For use on all CombiFlash® and Torrent systems 60-5237-044 AN94, Information Rich Flash Chromatography II All-Wavelength
AN51, RediSep C18 Column—Purification of Peptides Collection and Purity Measurement
Fits 130 and 260 gram sample load cartridges.
Prepacked Disposable For use on CombiFlash® Torrent systems 60-5247-008 AN55, RediSep C18 Column—Purification of Low-solubility AN102, Mass-directed Purification of Steroids with APCI
Sample Load Cartridges Fits 375 and 750 gram sample load cartridges.
Polar Heterocycles and PurIon
Normal Phase Silica C18 For use on CombiFlash® Torrent systems 60-5247-009 AN58, Non-Aqueous Reverse Phase with RediSep Gold® C18
Size Qty Catalog # Qty Catalog #
Peptides
2.5 g 20 69-3873-238 - - Amine AN01, Peptide Separations Using Reverse Phase RediSep Columns
5g 20 69-3873-236 5 69-3873-237 AN31, RediSep Amine Column–Purification of high pKa AN103, Save Time and Money by Purifying Peptides Yourself
12 g 15 69-3873-243 4 69-3873-248 Organic Compounds Case Study 1
AN106, Purification of a Peptide ACE Inhibitor Using the
25 g 15 69-3873-241 4 69-3873-242 AN99, Use of RediSep Gold® Amine Columns in the Weak Ion ACCQPrep HP125 or HP150
32 g 12 69-3873-310 - - Exchange Mode AN109, The Effect of Reverse Phase Chain Length on Peptide
65 g 4 69-3873-226 - - Poster Reprint, Advanced Topics RediSep Specialty Media Purification
260 g 4 69-3873-202 - - AN113, Reverse Phase Column Choice Affects Peptide Purity
C18Aq AN115, Purification of Peptide-Peptoid Hybrids
AN76, RediSep Gold® C18Aq for Highly Aqueous Mobile Phases
Self-pack Flash Column Frits
Size Catalog # AN95, Desalting Samples with RediSep Gold® C18Aq Columns General Information
AN20, Acetone as an Alternative to Ethyl Acetate
Package of 150 frits, 5 gram 60-5237-052 AN97, Removal of Non-volatile Solvents with RediSep Gold®
Package of 100 frits, 25 gram 60-5237-053 C18Aq Columns TN60, Use RediSep Columns Everywhere!
Package of 75 frits, 65 gram 60-5237-054 AN 118, HPLC to Flash
Solid Load Cartridges
AN 119 Generate Reverse Phase Flash Focused Gradients at
AN15, Dry Samples Improve Resolution in Normal Phase Flash Lightning Speed
RediSep Bulk Media Chromatography
Media Particle Container Size Catalog # AN 121, Method Transfer to RediSep Gold C18 8.6 kg columns.
Gold Silica 20–40 μm irregular 90 kg 60-2207-419
Our full library is availible online at
teledyneisco.com/en-us/chromatography/application-notes
teledyneisco.com 14RediSep Prep HPLC Columns ®
RediSep Prep Guard Columns
®
Maximize your Preparativee HPLC performance
RediSep Prep Guard columns help to maximize the practical lifetime
When you need the highest purity compound, your first choice should
ould be of your Prep column investment. Over time, the performance of a Prep
Teledyne ISCO’s RediSep Prep columns. RediSep Prep columns are specifically column declines with the accumulation of impurities and particles onto
designed for high performance preparative liquid chromatography (Prep
Prep HPLC). the inlet frit and the head of the column. An inexpensive guard column
Maximum purity prevents these impurities and particles from reaching your valuable prep
The columns are packed with 5μm particles for maximum purity. column. Once you begin to see increased backpressure or changes
in chromatography (such as peak broadening or changes in retention
Easy method development
times), switch out the guard column to see improved performance.
Quickly optimize your method using minimal sample with RediSep Prep
ep HPLC
analytical columns.
RediSep Prep Guard Columns (5 μ)
Specifications: Size Catalog #
• Particle size: 5 μm spherical 30 mm, Guard C18, 100 Å 69-2203-804
• Mesh size: 400–632 The ACCQPrep
30 mm, Guard C18Aq, 100 Å 69-2203-805 HP150 Prep
• Pore size: 100 Å C18, C18Aq, Silica (200 Å C8) HPLC system
• Surface area m2/g: 300 ±50
• Endcapped: Yes (Except silica)
• Carbon: 16.0–18.0% (C18) RediSep Prep HPLC and Guard
10.0–12.0% (C18Aq)
4.0–6.0% (C8) columns use stationary phase
• Loading capacity: 0.1–2% with matching selectivity to our
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CTS
PEPTIDES SMALL MOLECULES NATURAL PRODUCTS
RediSep Prep HPLC Columns (5 μ)
Size Catalog #
RediSep Prep UPLC Columns
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Length/Diameter (ID) 4.6 mm 10 mm 20 mm 30 mm 50 mm Method Development Columns
150 mm, C18, 100 Å 69-2203-800 69-2203-808 69-2203-810 69-2203-812 69-2203-814 Matching UPLC column media to our Prep columns allows for method development on analytical UPLC systems and
150 mm, C18Aq, 100 Å 69-2203-801 69-2203-816 69-2203-818 69-2203-820 69-2203-822 method transfer to our RediSep Prep HPLC columns on Preparative HPLC systems like the ACCQPrep HP150. For
more information see our paper: Silver, J. “Overview of Analytical-to-Preparative Liquid Chromatography Method
150 mm, C8, 200 Å 69-2203-856 69-2203-857 69-2203-858 69-2203-860 69-2203-862
Development.” ACS Combinatorial Science, 2019 21 (9), 609-613. DOI: 10.1021/acscombsci.8b00187
150 mm, Silica, 100 Å 69-2203-802 69-2203-824 69-2203-826 69-2203-828 -
250 mm, C18, 100 Å - 69-2203-809 69-2203-811 69-2203-813 69-2203-815 RediSep Prep UPLC Columns (2.8 μ)
250 mm, C18Aq, 100 Å - - - - 69-2203-823 Size Catalog #
250 mm, C8, 200 Å - - 69-2203-859 69-2203-861 69-2203-863 50 mm, C8, 200 Å, 2.8 μ 69-2203-853
250 mm, Silica, 100 Å - - 69-2203-827 69-2203-829 69-2203-831 50 mm, C18, 100 Å, 2.8 μ 69-2203-854
50 mm, C18Aq, 100 Å, 2.8 μ 69-2203-855
teledyneisco.com 16CombiFlash ®
NextGen 300+
Flash Chromatography System
The CombiFlash NextGen Flash Chromatography System
offers the most options in regards to system configurations.
Now there are three different models to choose from based
on your budgetary and application needs.
Setting a New Bar in Flash
Chromatography Performance
The CombiFlash NextGen 300+ features all available
performance and safety options. Flow rate range is from
1 to 300 mL/min at operating pressures up to 300 psi
(20 bar). The system is fitted with a solid load injection
valve that can be bypassed if you decide to perform
a liquid injection. RFID technology comes standard and • Straightforward
automatically reads the size and type of RediSep or Complete control on one screen
RediSep Gold® column being used for the purification. • Compact
Based on this information, a default gradient and flow rate Designed to take up minimal lab space
are programmed into the system. Simply insert the column
• Flexible
into the stand, press Play and the run starts. This same RFID Configure to meet your specific needs
technology automatically reads the rack type being used
• Faster
ensuring there is never a missed or overfilled tube. Active
New default methods with higher flows and
solvent and waste level monitoring is standard on the steeper gradients speed up the purification
NextGen 300+. Ensures that the column never dries out without sacrificing performance
during the purification run and no messy solvent spills.
• Greener
Conserve solvent with optimized gradients
Standard System Features
• Flow rates from 1 to 300 ml/min
Can be fitted with an ELSD at the time of system purchase.
• Operating pressure up to 300 psi (20 bar)
NextGen 300+ is compatible with PurIon Mass Spectrometer or • Choice of UV, UV-Vis ELSD or MS options
ELS Detection. Upgrade at the time of purchase or in the field.SPECIFICATIONS
CombiFlash Model NextGen 300+ Programmable Gradients Linear, step, isocratic
Flow Rate Range 1–300 mL/min User Interface 12 or 15” capacitive touch screen
Sample Loading Technique Liquid and Solid (standard) Fraction Collector Internal
Maximum Pressure -Up to 300 psi (20 bar) Rack Size RFID Read Standard
-User defined pressure limits
Real Time Method Editing Standard
UV and UV-Vis Detection Variable UV 200–400 nm
Active Solvent and
or Variable UV-Vis 200–800 nm Standard
Waste Level Monitoring
(PDA Technology)
Internal Vapor Sensor Option at time of purchase
Real Time UV Spectral Display Standard
Vapor Enclosure for
Absorbing Solvent Optional
Standard Collection Racks
Baseline Substract
Audible Alarm Standard
ELSD Detection Integrated option with UV or UV-Vis
Lighted Rack Area Standard
Number of Solvents Binary gradient, 4 solvents
Dimensions (H x W x D) 26 x 14.1 x 17 in (66 x 36 x 43 cm)
Modifier 3rd Solvent Standard
Weight with ELSD 74 lb (33.6 kg)
Gradient Formation Low pressure
Weight without ELSD 61 lb (27.7 kg
COMBIFLASH NextGen 300+
685250001 CombiFlash NextGen 300+ System with 200–400 nm UV variable wavelength detector, 12” screen.
685250002 CombiFlash NextGen 300+ System with 200–800 nm UV-Vis variable wavelength detector, 12” screen.
685250003 CombiFlash NextGen 300+ System with 200–400 nm UV variable wavelength detector, 15” screen.
685250004 CombiFlash NextGen 300+ System with 200–800 nm UV-Vis variable wavelength detector, 15” screen.
CombiFlash NextGen 300+ Factory Options
605257001 Factory installed ELSD for CombiFlash NextGen 300 & 300+ (only available when ordered with initial system purchase.)
605257005 Factory installed Vapor Sensor for all CombiFlash NextGen models.
CombiFlash NextGen 300+ Field Options
605257008 Sample rack vapor enclosure for operation outside the hood.
605257007 ELSD Field Upgrade Kit for CombiFlash NextGen 300+ systems.
CombiFlash Sample Injection Options
60-5237-047 Adjustable Solid Load Cartridge Cap (SLCC), fits 2.5 and 5 gram-size sample load cartridges.
Includes one loading rod.
60-5237-048 Adjustable Solid Load Cartridge Cap (SLCC), fits 12 and 25 gram-size sample load cartridges.
Includes one loading rod.
60-5237-044 Adjustable Solid Load Cartridge Cap (SLCC), fits 32 and 65 gram-size sample load cartridges.
Includes one loading rod.
Teledyne ISCO
P.O. Box 82531, Lincoln, Nebraska, 68501 USA
Toll-free: (800) 228-4373 • Phone: (402) 464-0231 • Fax: (402) 465-3091
E-mail: isco.info@teledyne.com
teledyneisco.com
Teledyne ISCO is continually improving its products and reserves the right to change product L-5214 Rev 4.0
specifications, replacement parts, schematics, and instructions without notice. 6/18CombiFlash® EZ Prep
Streamline Flash and Preparative HPLC chromatography
with a compact, easy-to-operate unit
The CombiFlash EZ Prep streamlines the purification process,
quickly switching from Flash to high-pressure preparative
chomatography in just two clicks. Pre-purify on Flash
followed by Prep for submission quality compounds.
User-friendly PeakTrak® software controls both Flash and Prep
HPLC chromatographic conditions. Additionally, PeakTrak
integrates all detector options, including the CombiFlash
PurIon mass spectrometer for single point control.
z Simplicity Prep LC in a Flash
Simplest transition of any Flash/Prep HPLC system –
switch to high-pressure preparative chromatography Standard System Features
in just two clicks • Up to 3500 psi (240 bar) and 200 mL/min
• Run Prep HPLC columns up to 50 mm in diameter (including
z Small Footprint 5 μm particle diameter)
Highly compact design occupies minimal lab space
• Flash purification for 10 milligram to 33 grams followed by final
compound purification on high performance columns
z Compatibility
Runs Preparative HPLC columns packed with particles • UV, UV-Vis, ELSD and MS detection options available
down to 5 μm for maximum efficiency • Switch between normal and reverse phase solvents
automatically, without user interaction
It’s easy!
1 Select preparative HPLC column
1 3 from the drop down menu. The
2 system automatically switches
from Flash to HPLC Prep Mode.
2 Press play.
3 Review results.Instruments
smart solutions & service
I GZ Instruments AG Tel. +41 44 456 33 33
Räf felstrasse 32
CH – 8045 Zürich
Fax +41 44 456 33 30
www.igz.ch igz@igz.ch
Prep LC in a Flash
Specifications
Flow Rate Range 5-200 mL/min (Flash & Prep)
Pump Prime Self-priming
Maximum Pressure (Flash Operation) 200 psi (13.8 bar)
Maximum Pressure (High Pressure Operation) Up to 3500 psi (240 bar)
UV and UV Vis Detection UV 200-400 nm standard, UV vis 200-800 nm optional
ELSD Detection Built-in detector compatible with either UV or UV-Vis
Mass Spectometer Three models with mass ranges of 10-1200 and 10-2000 Da.
Number of Solvents Binary gradient between any two of four solvents
Programmable Gradients Linear, step, isocratic
Sample Introduction (Flash) Solid or liquid load
Sample Introduction (Prep) Variable volume liqid load (5mL loop standard)
User Interface 10.4” touchscreen
Fraction Collector Internal
Dimensions (H x W x D) 26.8” x 16.9” x 17” (68 x 43 x 43.2 cm)
Ordering Information
68-5230-025 CombiFlash EZ Prep Chromatography System with 200-400 nm UV variable wavelength detector
68-5230-026 CombiFlash EZ Prep Chromatography System with 200-800 nm UV-Vis variable wavelength detector
68-5230-027 CombiFlash EZ Prep Chromatography System with 200-400 nm UV variable wavelength and ELS detectors
68-5230-028 CombiFlash EZ Prep Chromatography System with 200-800 nm UV-Vis variable wavelength and ELS detectors
Purlon Mass Spectrometer Upgrade Options
68-5237-050 CombiFlash Purlon Mass Spectrometer and Fluid Interface. Basic MS module with maximum mass of 1200
Dalton. User selectable positive or negative ionization. ESI or APCI probe standard, to be defined on order.
68-5237-083 CombiFlash Purlon Mass Spectrometer and Fluid Interface. Mass spec “S” with probe and fluid interface, MS model S module
with maximum mass of 1200 Dalton, system auto-switches between positive and negative ionization. ESI or APCI probe
standard, to be defined on order.
68-5237-084 CombiFlash Purlon Mass Spectrometer and Fluid Interface. Mass Spec “L” with probe and fluid interface. MS model L module
with maximum mass of 2000 Dalton. System auto switches between positive and negative ionization. ESI or APCI probe
standard, to be defined on order.
Preparative Injector Valve Options
29-9125-051 1 mL Injection Loop
29-9125-050 5 mL Injection Loop (standard)
29-9125-052 10 mL Injection Loop
29-9125-060 Injector Fill Port for use with 2” long 22 gauge blunt tip needle
60-5238-240 Injector Fill Port Female Luer Adapter (standard)
4700 Superior Street, Lincoln, NE 68504 USA • Tel: (402) 464-0231 • USA & Canada: (800) 228-4373
L-5202 06/15
Fax: (402) 465-3022 • Email: iscoinfo@teledyne.com
Teledyne Isco reserves the right to change specifications without notice.
©2015 Teledyne Technologies IncorporatedTeledyne Isco Automation Modules
For CombiFlash® EZ Prep
Maximize the throughput and flexibility of your CombiFlash EZ Prep
by adding automation for longer unattended operation.
We offer three different options for automating the CombiFlash EZ Prep purification system. These options can be used
independently or in combination with one another to meet your application needs.
AutoInjector Module
The AutoInjector is designed for the user who needs to make multiple
purification runs of the same sample. Simply input the volume of sample
you have and the number of injections needed for purification.
• Automate multiple
injections of the same
sample with up to 100
repeat injections totaling
up to 1 liter of sample
• Automatic cleaning
procedure eliminates
carry-over
Utilize the simple single-screen user interface.
AutoSampler Module
If you have several different samples to purify which may require multiple
injections and different chromatographic conditions, the AutoSampler is the
right product for you. Build a simple sample table in seconds, press start, and
let the system do the rest. RFID identification on sample load and collection
racks eliminates errors.
• Add new samples to the
queue at any time
• Expand fraction collector
capacity with the two
additional collection racks
on the AutoSampler deck
• Washes the probe between
samples to eliminate
carry-over
Make your priority sample run next.Column Selector Module
Define up to four columns and their respective
position in the EZ Prep’s configuration screen for
fast set up. When you select the column needed for
your purification,
Use all four positions for different columns or dedicate a position to bypass for
Isco’s PeakTrak® system flush.
switches the • The Column Selector has positions for up to four
column selector preparative columns with diameters from
valve to the 10 – 50 mm and lengths up to 250 mm
correct position. • Reduce leaks from manual column changes
• Use alone or in conjunction with the
AutoInjector or the AutoSampler
• Maximize available bench space by mounting the
Column Selector Module to the side of the EZ Prep or
by stacking it under the AutoSampler
Automation Modules Specifications
68-5237-088 AutoInjector Module Dimensions ( H x W x D )
68-5237-092 AutoSampler Module with sample AutoInjector Module 5.0 x 1.9 x 6.3 in
load and collection racks (12.7 x 4.8 x 16.0 cm)
68-5237-093 AutoSampler Upgrade for an AutoSampler Module 18.9 x 14.0 x 19.3 in
AutoInjector. Includes sample load (48.0 x 35.6 x 49.0 cm)
and collection racks
Column Selector Module 14.5 x 4.6 x 16.1 in vertical
68-5237-091 Column Selector Module (36.8 x 11.7 x 40.9 cm vertical)
4.6 x 14.5 x 16.1 in horizontal
(11.7 x 36.8 x 40.9 cm horizontal)
Sample Load Racks for AutoSampler Weight
60-5234-637 Sample load rack,13 mm AutoInjector Module 4.0 lbs (1.8 kg)
(28 tubes/rack)
AutoSampler Module 31.1 lbs (14.1 kg)
60-5234-638 Sample load rack, 28 mm
(12 scintillation vials/rack) Column Selector Module 12.9 lbs (5.9 kg)
Collection Racks for AutoSampler
60-5237-013 Collection racks, 13 x 100 mm (108 tubes/rack). Set of 2.
60-5237-061 Collection racks, 16 x 100 mm (75 tubes/rack). Set of 2.
60-5237-031 Collection racks, 16 x 125 mm (75 tubes/rack). Set of 2.
60-5237-032 Collection racks, 16 x 150/160 mm (75 tubes/rack). Set of 2.
60-5237-033 Collection racks, 18 x 150 mm (70 tubes/rack). Set of 2.
60-5237-034 Collection racks, 18 x 180 mm (70 tubes/rack). Set of 2.
60-5237-035 Collection racks, 25 x 150 mm (30 tubes/rack). Set of 2.
60-5237-040 Collection rack, 480 ml square bottle (12 bottles/rack). Qty 1.
60-5394-469 Collection racks, 28 x 61 mm (27 scintillation vials/rack, 20 ml). Set of 2.
60-5394-468 Collection racks, 28 x 95 mm (27 scintillation vials/rack, 40 ml). Set of 2.
4700 Superior Street, Lincoln, NE 68504 USA • Tel: (402) 464-0231 • USA & Canada: (800) 228-4373
L-5211 051816
Fax: (402) 465-3022 • Email: iscoinfo@teledyne.com • www.teledyneisco.com
Teledyne Isco reserves the right to change specifications without notice.
©2016 Teledyne Technologies IncorporatedACCQPrep HP150 ™
Preparative HPLC
The Teledyne ISCO ACCQPrep™ HP150 is designed to be intuitive and easy-to-
use with all the performance and accuracy of an HPLC system. The ACCQPrep
focuses on purification with the highest sample recovery.
Achieve High Performance Preparative
Liquid Chromatography (HPPLC)
simply, without compromise.
With ease of purification in mind, the user-friendly ACCQPrep HP150 eliminates
unnecessary and complex method parameters found in many of the HPPLC
systems in today’s market. Our PeakTrak® software, designed with the user in
mind, is the basis for controlling the ACCQPrep HP150. The integrated software,
eliminates the need for a stand-alone PC. This results in a more compact unit
with a touch screen interface. Software evolves with user needs and updates are
always free.
•Straightforward
Enjoy the confidence associated with Teledyne ISCO’s active solvent and waste Complete control of the system on one screen
level monitoring, which reduces the risk of solvent spills. In addition, never miss or
overfill test tubes again with RFID collection racks. •Compact
The ACCQPrep HP150 creates high accuracy gradients and low dwell volumes Designed to take up minimal lab space
with dual piston, high pressure pumps. Operate across the full range of flow rates
from analytical (1 mL/min) to 50 mm and larger preparative columns (150 mL/min), •Flexible
without the need to switch out pump heads. Save method development time by Add on Teledyne ISCO Automation Modules
scouting on an analytical column, and scale up to prep on one system, with a and other sample injection and detection
single touch. options for your separation needs
Standard Features:
• Flow rates from 1 to 150 mL/min allows
scouting and Prep methods on one system
• Operating pressure up to 6,000 psi
• Choice of UV or UV-Vis plus ELSD and
MS options
• One touch Focused Gradient Generator
maximizes purification time and sample
recovery
The system is ready for hours of unattended PurIon Mass Spectrometer takes the guess
operation when combined with optional work out of your purification routine with
automation modules. mass directed fractionation.ACCQPrep™ HP150 Selection Information
Flow Rate Range: 1–150 mL/min ACCQPrep HP150 Systems
Pressure Limit: Up to 6,000 psi (400 bar) ACCQPrep HP150 System with 200-400 nm – UV PDA detector . . . . . . . . . .685230053
ACCQPrep HP150 System with 200-800 nm – UV-Vis PDA detector . . . . . . .685230054
UV and UV- Vis Variable UV 200–400 nm,
Detection: Variable UV-Vis 200–800 nm (optional)
Factory Installed Options
ELSD Detection: Integrated Option
Integrated ELSD, factory installed. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .605237135
Number of Solvents: Binary gradient, 2 solvents, 2 x 3 solvents (optional), ACCQPrep AS 2x2 – AutoSampler Module Factory Installed with sample load
Fixed third solvent modifier (optional) and collection racks, includes the AI-5 (685237101)
Gradient Formation: High pressure, dual piston reciprocating pumps 2 racks, (75) 16 mm tubes/rack . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .685237127
ACCQPrep AS 4x2 – AutoSampler Module Factory Installed with sample load
Programmable Linear, step, isocratic
and collection racks, includes the AI-5 (685237101)
Gradients:
4 racks, (75) 16 mm tubes/rack . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .685237140
Gradient Linearity: +/- 1% ACCQPrep AI 5 – AutoInjector Factory Installed . . . . . . . . . . . . . . . . . . . . . . .685237098
Sample Introduction: Injection loop (standard) ACCQPrep CSV 4 – Column Selector Valve Module Factory Installed . . . . . .685237099
Manual (standard)
ACCQPrep SSV 2x3 – Solvent Selector Valve Module Factory Installed . . . .685237100
AutoInjector (optional)
Large sample load pump (optional)
User Installed Options
User Interface: 15 in touchscreen, internal CPU, Linux Red Hat
Large Volume Sample Load Pump . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .685237131
Fraction Collector: Internal, External Fraction Collection with Waste Collection Switching Valve. . . . . . . . . . . . . . . . . . . . . . . . . . . 685237132
AutoSampler (Optional)
Third Solvent Modifier Pump. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .685237136
Dimensions (H x W x D) 27.5 x 14.0 x 20.0 in (69.9 x 35.6 x 50.8 cm)
ACCQPrep: 84.5 pounds (38.2 kg) ACCQPrep AI 5 – AutoInjector User Installed . . . . . . . . . . . . . . . . . . . . . . . . .685237101
ACCQPrep CSV 4 – Column Selector Valve Module User Installed . . . . . . . .685237102
Dimensions AS 2x2 (H x W x D) 18.9 x 14.0 x 19.3 in (48.0 x 35.6 x 49.0 cm)
AutoSampler Module: 31.1 pounds (14.1 kg) ACCQPrep SSV 2x3 – Solvent Selector Valve Module User Installed . . . . . .685237104
Dimensions AS 4x2 (H x W x D) 27.5 x 23 x 22 in (69.9 x 58.4 x 55.9 cm)
AutoSampler Module: 42.2 pounds (19.1 kg) Mass Directed Options
Mass Spec “S” with Fluid Interface . . . . . . . . . . . . . . . . . . . . . . . . .685237083
Mass Spec “L” with Fluid Interface. . . . . . . . . . . . . . . . . . . . . . . . . .685237084
APCI Ion Source for Base, S and L Mass Spec options. . . . . . . . . . . . . . . . . 250000125
ESI Ion Source for Base, S and L Mass Spec options . . . . . . . . . . . . . . . . . . 250000129
Large Volume Sample Load Pump Waste Collection Switching Valve Third Solvent Modifier Pump
Used for injecting volumes of samples greater Interfaces with AS 2x2 and 4x2. Directs waste Controlled via PeakTrak and provides delivery
than 10 mL directly onto the column bypassing the from up to 12 samples into separate waste of a third solvent at a fixed percentage during
injection loop. Pump is controlled via PeakTrak. reservoirs. Ideal for open access to separate the purification.
individual sample wastes. Requires presence
of either the AS 2x2 or AS 4x2.
Teledyne ISCO
P.O. Box 82531, Lincoln, Nebraska, 68501 USA
Toll-free: (800) 228-4373 • Phone: (402) 464-0231 • Fax: (402) 465-3091
teledyneisco.com
Teledyne ISCO is continually improving its products and reserves the right to change product L-2221 Rev 1.0
specifications, replacement parts, schematics, and instructions without notice. 03/19PREP SFC 250 Preparative Scale Separation – Compact Design
PREP SFC 250 SYSTEM
Sepiatec’s new Prep SFC 250 system is a compact The column oven, containing the chromatography
benchtop unit designed for preparative separa- columns together with the injection valve and the
tions using supercritical fluid chromatography. UV flow cell, is heatable up to 70° C so that a
uniform temperature is ensured.
Measuring just 72 x 60 x 88 cm (W x D x H) the
system offers all advantages of SFC technology The fractionation module includes a selector
such as fast separations, reduced consumption valve and 9 gas-liquid separators (1 for waste).It is
of organic solvents, lower costs, improved en- designed for 8 fraction bottles with a volume of 1
vironmental compatibility and increased safety. litre each. Due to the flexible outlets even bigger
sample containers with volumes up to several
The Prep SFC 250 system uses two high-pressure litres can be used.
pumps fitted with 150 ml pump heads. Total flow
rates of up to 250 ml of supercritical fluid per A system controller with current performance
minute can be achieved at a modifier portion of characteristics is built into the device. There is no
40 %. This allows the operator to use separation need for a separate computer, and no additional
columns with internal diameters of 15 to 30 mm bench space is required.
and lengths of 250 mm.
Data is entered via the 15.6‘‘ touch screen, which
Due to its compact design the footprint of the is placed ergonomically on the upper front of the
Prep SFC 250 system is comparatively small and Prep SFC 250 system.
precious laboratory space can be saved. The
clearly arranged assembly of the Prep SFC 250 An additional monitor at a separate work site can
system allows easy access to all of its modules. also be connected.PREP SFC 250 SOFTWARE The Prep SFC 250 system is controlled entirely for inputting separation parameters for different by means of the Prep SFC control software samples, functions such as stack injection with which offers a clear menu structure enabling automatic suggestions for stack times, multiple simple and intuitive operation. All input options options for fractionation and on-the-fly editing are presented on just a few screens. The Prep for changing parameters during the course of a SFC control software includes a sequence editor run. PREP SFC 250 SYSTEM WITH MASS SPECTROMETER As an option Sepiatec’s Prep SFC 250 system can be combined with Advion’s expression CMS. The expression CMS is a very compact mass spectrometer featuring the latest single qua- drupole technology. The system as a whole, consisting of Prep SFC 250 and expression CMS, allows users to perform mass-directed-, mass- confirmed- and UV-controlled fractionation. The exact molecular weights of the separated substances are quickly and reliably measured, and even UV-inactive targets can be fractio- nated. The ion source consists of an ESI option and an APCI option, which can both produce anions or cations as required. All the modules needed to connect the expres- The expression CMS software allows users sion CMS to the Prep SFC 250 system, such as to perform a wide range of assessments. a make-up flow pump and a split valve, are in- The compact size of the Prep SFC 250 and cluded. The expression CMS mass spectrometer the expression CMS means that they can be is operated and the data obtained are displayed installed together in a standard laboratory using the Prep SFC 250 system software. fume hood.
Sepiatec GmbH . Johann-Hittorf-Str. 8 . 12489 Berlin, Germany
Phone: +49 (0) 30 - 63 22 34 0 . Facsimile: +49 (0) 30 - 63 22 34 10 . info@sepiatec.com . www.sepiatec.com
TECHNICAL DATA
PREP SFC 250
Operating mode 1 semi-preparative or preparative column
Suitable columns 15 to 30 mm ID, max. 250 mm in length
Solvents CO2 and organic solvents
Number of modifier solvents 1 standard, 4 with optional solvent selection valve
Total flow rate 250 ml/min at a modifier portion of 40 %
CO2 pump 150 ml pump head, 400 bar
Modifier pump 150 ml pump head, 400 bar
Add-on pump 30 ml pump head, 400 bar (optional)
Operating pressure Up to 300 bar, back pressure regulator online adjustable
Injection Partial loop with syringe pump
Ambient temperature to 70° C, 2 columns standard,
Column oven
6 columns with optional valves
UV detector Wavelength range 190 to 500 nm
Other detectors DAD, ELSD or mass spectrometer optional
Fractionation 1 to 8 fractions, unlimited volumes, pressure-less fraction collection
With additional CO2 recycling module (optional),
CO2 Recycling
gaseous to liquid CO2 conversion, about 85 % recovery
Software Prep SFC control software
System controller Integrated controller, Windows 10
Screen 15.6“ touch screen, 16:9 format
Connections 3 USB ports, Ethernet, HDMI
Dimensions 72 x 60 x 88 cm (W x D x H)Prep SFC M5 Versatile SFC System for Chiral and Achiral Separations
Prep SFC M5 SYSTEM
Sepiatec‘s new Prep SFC M5 system is a prepa- switched using two integrated column switching
rative system for separating chiral and achiral valves. The column oven is heatable up to 70°
samples using supercritical fluid chromatography. Celsius. Standard equipment in the main module
is a UV detector for measuring in the range of 190 –
The Prep SFC M5 system consists of the main 500 nm. Additional detectors, such as an ELSD,
module and the collector module. Both modules can also be connected. An optional compact mass
form a functional unit that can be configured in a spectrometer is available for separations with
variety of ways with different equipment. mass directed fractionation.
The main module can be equipped with up An integrated control computer and 10“ TFT
to three high pressure pumps, a CO2 pump, touch screen is used to input all data for sample
a modifier pump and an optional add-on pump separations. No additional computer is required,
for separations with low modifier portions. reducing the space required for the Prep SFC M5
The available options include: system to a width of just 91.5 cm.
. Pumps with 100 ml pump heads, The collector module has a continuously-opera-
flow rates 0.2 – 100.0 ml/min, 400 bar ting gas-liquid separator that makes a vertical
movement when switching to a new fraction
. Pumps with 30 ml pump heads, vessel. A valve closes the outlet of the gas-liquid
flow rates 0.1 – 30.0 ml/min, 400 bar separator while the vessel is being changed.
A new collection simply involves lowering a short
. Add-on-pumps with 30 ml pump heads, capillary into the opening of the fraction vessel,
flow rates 0.1 – 30.0 ml/min, 400 bar which virtually precludes the risk of carry-over.
The integrated auto sampler can accommodate The easily exchangeable round holder for the
two standard or deep-well microtiter plates or fraction collector vials provides ideal overview.
racks with up to 60 sample vials with a volume It is available in several models: 38 vials each of
of 1.5 ml each. 10 ml volume, 22 vials with 40 ml or 12 flasks with
100 ml volume each. The collector module has a
The column oven contains up to 10 separation removable and transparent protective cover and
columns with internal diameter of 4 to 30 mm comes with a connector port for an aspirator that
and a length of up to 250 mm. The columns are facilitates use at a standard laboratory bench.Prep SFC M5 SYSTEM WITH SORTER MODULE
Possibilities for collecting and processing . Continuous placement of new empty vials
fractions using the Prep SFC M5 system can into the holder of the collector module, thus
be expanded with the optional sorter module. expanding the collection capacity to several
hundred fractions
The sorter module is a handling robot designed
for interacting with the collector module of the . Weighing of vials that are removed from the
Prep SFC M5 system. It is available in a variety collector module, which are then to be dried
of different sizes and can be equipped with in an evaporator, automatic preparation of a
various gripper arms. A wide range of variants “counter vial” with identical weight, positioning
and functions is possible with the addition of of both vials in the holding tray of the evaporator
various components:
. A variety of other sample preparation processes
. Continuous removal of vials from the collector for further analysis of collected fractions
module with sorting according to pre-selected
criteria
Prep SFC M5 SOFTWARE
The Prep SFC M5 system is controlled entirely suggestions for stack times and multiple options
by means of the Prep SFC control software for fractionation. A computer at a separate work
which offers a clear menu structure enabling site can also be connected.
simple and intuitive operation. All input options
are presented on just a few screens. The soft- If an optional mass spectrometer is used, control
ware includes a sequence editor for inputting and data acquisition also take place directly via
separation parameters for different samples, the Prep SFC control software.
functions such as stack injection with automaticSepiatec GmbH . Johann-Hittorf-Str. 8 . 12489 Berlin, Germany Phone: +49 (0) 30 - 63 22 34 0 . Facsimile: +49 (0) 30 - 63 22 34 10 . info@sepiatec.com . www.sepiatec.com TECHNICAL DATA Prep SFC M5 SYSTEM Operating mode 1 analytical, semi-preparative or preparative column CO2 pump, 30 ml heads, flow rates 0.1 – 30.0 ml/min, 400 bar, optionally 30 ml or 100 ml 100 ml heads, flow rates 0.2 – 100.0 ml/min, 400 bar Modifier pump, 30 ml heads, flow rates 0.1 – 30.0 ml/min, 400 bar, optionally 30 ml or 100 ml 100 ml heads, flow rates 0.2 – 100.0 ml/min, 400 bar Add-on pump, 30 ml (optionally) 30 ml pump head, flow rates 0.1 – 30.0 ml/min, 400 bar Number of modifier solvents 1 standard, max. 4 solvents with optional selection valve Backpressure range Up to 300 bar, adjustable online backpressure control Sample injection Partial loop with syringe pump Auto sampler 2 MTP or 2 deep well plates 96 well or 60 vials 1.5 ml Number of columns and size Max. 10 columns, 4 to 30 mm ID, up to 250 mm length Column oven Ambient temperature to 70°C, integrated flow cell UV Detector Standard, wavelength 190 to 500 nm ELSD Optionally available Mass spectrometer Optionally available Fraction collector Holders for 38 vials 10 ml, 22 vials 40 ml or 12 flasks 100 ml Software Prep SFC control software, Sequence Editor M5 software System controller Integrated PC, Windows, 10” TFT touch-screen Connections 3 USB ports, Ethernet, HDMI Dimensions, weight 91.5 x 60 x 88 cm (W x D x H), 148 kg Technical data of the Prep SFC M5 sorter module available on request
SEPMATIX 8x HPLC
The Sepmatix 8x System Screening HPLC from spend time adapting methods to the new
Sepiatec only uses one external HPLC pump. system or to purchase any new costly HPLC
The flow is separated by the patented Sepmatix columns. Different designs of the Sepmatix 8x
Flow Control into eight channels, and the flow System Screening HPLC are available for appli-
in each channel is precisely measured and re- cations such as chiral column screening, protein
gulated throughout the entire run. Together screening, method development, or with an 8x
with an Autosampler and a detector with 8 Fraction Collector for preparative work.
independent spectrometer modules working
in parallel. The required space for the Sepmatix 8x System
Screening HPLC is only 55 x 55 x 90 centimetres
The result is an unbelievably compact HPLC sys- (W x D x H).
tem, which will instantly enhance the through-
put of every research and development labora- A column oven for heating purposes according
tory eight times over. It is not necessary to to customer’s requirements is also available.
Column 1 Column 2 Column 3 Column 4 Column 5 Column 6 Column 7 Column 8
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
1 1 1 1 1 1 1 1
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
CO2-EtOH 90:10 5ml 0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid 0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5
0,4 0,4 0,4 0,4 0,4 0,4 0,4 0,4
0,3 0,3 0,3 0,3 0,3 0,3 0,3 0,3
0,2 0,2 0,2 0,2 0,2 0,2 0,2 0,2
0,1 0,1 0,1 0,1 0,1 0,1 0,1 0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
1 1 1 1 1 1 1 1
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
CO2-EtOH 95:05 5ml 0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid 0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,2 0,2 0,2 0,2 0,2 0,2 0,2 0,2
0,1 0,1 0,1 0,1 0,1 0,1 0,1 0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
1 1 1 1 1 1 1 1
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
CO2-IPA 90:10 5ml 0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid
0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5
0,4 0,4 0,4 0,4 0,4 0,4 0,4 0,4
0,3 0,3 0,3 0,3 0,3 0,3 0,3 0,3
0,2 0,2 0,2 0,2 0,2 0,2 0,2 0,2
0,1 0,1 0,1 0,1 0,1 0,1 0,1 0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
1 1 1 1 1 1 1 1
CO2-IPA 95:5 5ml
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
0,8 0,8 0,8 0,8 0,8 0,8 0,8 0,8
0,7 0,7 0,7 0,7 0,7 0,7 0,7 0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid 0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,5
0,4
0,3
0,2 0,2 0,2 0,2 0,2 0,2 0,2 0,2
0,1 0,1 0,1 0,1 0,1 0,1 0,1 0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
CO2-CH3CN (5%MeOH)
1 1 1 1 1 1 1 1
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
0,8 0,8 0,8 0,8 0,8 0,8 0,8 0,8
90:10 5ml
0,7 0,7 0,7 0,7 0,7 0,7 0,7 0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5
0,4 0,4 0,4 0,4 0,4 0,4 0,4 0,4
trans Stilbenoxid 0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
CO2-CH3CN (5%MeOH)
1 1 1 1 1 1 1 1
0,9 0,9 0,9 0,9 0,9 0,9 0,9 0,9
0,8 0,8 0,8 0,8 0,8 0,8 0,8 0,8
95:5 5ml
0,7 0,7 0,7 0,7 0,7 0,7 0,7 0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5
0,4 0,4 0,4 0,4 0,4 0,4 0,4 0,4
trans Stilbenoxid 0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0,3
0,2
0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min] [min] [min] [min] [min]
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1
0,9
1
1,1
0,9
1
1,1
0,9
1
1,1
0,9
1 1,2 1,1
0,9
1
1,1
0,9
1
1,1
0,9
1
1,1
0,9
1
CO2-MeOH 80:20 5ml 0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
1,1
0,8
0,7
0,8
0,7
0,8
0,7
0,8
0,7
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid 0,5
0,4
0,5
0,4
0,5
0,4
0,5
0,4
0,5
0,4
0,5
0,4
0,5
0,4
0,5
0,4
1
0,3 0,3 0,3 0,3 0,3 0,3 0,3 0,3
0,2 0,2 0,2 0,2 0,2 0,2 0,2 0,2
0,1 0,1 0,1 0,1 0,1 0,1 0,1 0,1
0 0 0 0 0 0 0 0
0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14
0,9 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14 0 1 2 3 4 5 6 7
[min]
8 9 10 11 12 13 14
0,8
1,2 1,2 1,2 1,2 1,2 1,2 1,2 1,2
1,1 1,1 1,1 1,1 1,1 1,1 1,1 1,1
0,9
1
0,9
1
0,9
1
0,9
1
0,7 0,9
1
0,9
1
0,9
1
0,9
1
CO2-MeOH 90:10 5ml
0,8 0,8 0,8 0,8 0,8 0,8 0,8 0,8
[AU]
0,7 0,7 0,7 0,7 0,7 0,7 0,7 0,7
0,6
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
[AU]
0,6 0,6 0,6 0,6 0,6 0,6 0,6 0,6
trans Stilbenoxid
0,5 0,5 0,5 0,5 0,5 0,5 0,5 0,5
0,4 0,4 0,4 0,4 0,4 0,4 0,4 0,4
0,3 0,3 0,3 0,3 0,3 0,3 0,3 0,3
0,2
0,1
0
0,2
0,1
0
0,2
0,1
0
0,2
0,1
0
0,5 0,2
0,1
0
0,2
0,1
0
0,2
0,1
0
0,2
0,1
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min] [min] [min] [min]
0,4 [min] [min] [min] [min]
0,3
0,2
0,1
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
[min]
Overview screening: 8 methods x 8 columns
Best resolutionSie können auch lesen
