GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV

 
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
Programm

                      © fotobeam.de l Fotolia.com

                  DPC
                      39. Jahrestagung des

                      Deutschen Pankreasclubs e. V.

                      7.– 9. Februar
                      Göttingen

www.dpc-kongress.de
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
WIR ENGAGIEREN UNS FÜR
                                  SCHWERWIEGENDE UND
                            SELTENE ERKRANKUNGEN MIT
                            DER FORSCHUNGSKOMPETENZ
                               ANTISENSE-TECHNOLOGIE

           2
DE-AKCEA-0009-V01-2018-10
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
INHALTSVERZEICHNIS

Organisation und Impressum . ...............................................................................................                4

Grußwort der Tagungsleitung ................................................................................................                5

Workshops I Donnerstag, 7. Februar ...................................................................................                      6

Wissenschaftliches Programm
     Donnerstag, 7. Februar ................................................................................................. 7
     Freitag, 8. Februar ......................................................................................................... 9
     Samstag, 9. Februar . ..................................................................................................... 14

Posterpräsentationen
     Donnerstag, 7. Februar ................................................................................................. 17
     Freitag, 8. Februar ......................................................................................................... 22

Abend- und Rahmenprogramm ............................................................................................. 27

Industriegestützte Sessions.................................................................................................... 28

Sponsoren und Medienkooperation ..................................................................................... 32

Aussteller ................................................................................................................................ 34

Raum- und Ausstellerplan ...................................................................................................... 35

Allgemeine Informationen ..................................................................................................... 36

Index Referenten, Autoren und Vorsitzende . ....................................................................... 37

                                                                                                                                           3
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
ORGANISATION UND IMPRESSUM

Tagungsort und Termin
Tagungs- und Veranstaltungshaus
Alte Mensa Göttingen
Wilhelmsplatz 3 I 37073 Göttingen
7.–9. Februar 2019

Tagungshomepage
www.dpc-kongress.de

Veranstalter
Deutscher Pankreasclub e. V.
www.pankreasclub.de

Wissenschaftliche Leitung
PD Dr. Dr. med. Albrecht Neeße
Klinik für Gastroenterologie und gastrointestinale Onkologie
Universitätsmedizin Göttingen

Tagungsorganisation
Conventus Congressmanagement & Marketing GmbH
Ariane Kärger/Carolin Hofmann
Carl-Pulfrich-Straße 1 I 07745 Jena
Tel. +49 3641 31 16-325/-378
dpc@conventus.de I www.conventus.de

Programmerstellung
Satz                 krea.tif-studio UG (haftungsbeschränkt)
Druck                printworld.com GmbH
Auflage              300
Redaktionsschluss    18. Januar 2019

4
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
GRUSSWORT DER TAGUNGSLEITUNG

Liebe Kolleginnen und Kollegen,

ich freue mich, Sie im Jahr 2019 zur 39. Jahrestagung des Deutschen Pankreasclubs e. V. nach
Göttingen, in die Stadt, die Wissen schafft, einzuladen.

Das Leitbild 2019 „Pankreatologie im Zeitalter der Viszeralmedizin: Translation und Vernetzung“
soll als Basis für den interdisziplinären wissenschaftlichen und klinischen Austausch dienen.

Nationale und internationale renommierte Experten werden Sie aktuell und praxisnah auf
den neuesten Stand der Pankreasforschung und klinischen Versorgung bringen. Zusätzlich
bieten wir auch 2019 wieder die Möglichkeit, sich am Donnerstagvormittag in klinisch und
translational orientierten Veranstaltungen und Workshops praxisrelevantes Wissen anzueignen.

Ich freue mich auf eine lebhafte Tagung, viele inspirierende Akzente und facettenreiche
Diskussionen.

Herzliche Grüße,

Ihr

Albrecht Neeße
                                                                                 © di
                                                                                  s p l ay
                                                                                    i nte r may a l f
                                                                                       o to lia.c o m

                                                                                                        5
GöttinGen 7.- 9. Februar - Programm - Jahrestagung des Deutschen Pankreasclubs eV
WORKSHOPS I DONNERSTAG, 7. FEBRUAR
WORKSHOPS I THURSDAY, 7 FEBRUARY

All workshops will take place at the University Hospital Göttingen (Robert-Koch-Straße 40).

09:30–12:30    Workshop 1 l Diagnostische und interventionelle Sonographie in der
               Pankreatologie (B-Bild, CEUS, EUS, EUS-FNA/FNB) mit Live Demo
Room           Department of Gastroenterology and Gastrointestinal Oncology

               B-Bild Sonographie der Pankreatologie
               V. Keim (Leipzig)

               CEUS
               G. Petzold (Göttingen)

               Endosonographie der Pankreatologie
               A. Arlt (Kiel)

               Live Demo
               S. Kunsch (Göttingen)

09:30–12:30    Workshop 2 l Syngenic orthotopic PDAC cell transplantation
Room           Laboratories Gastroenterology and Gastrointestinal Oncology

               Theory and Hands-on Training
               E. Hessmann (Göttingen)

09:30–12:30    Workshop 3 l High-resolution ultrasound and preclinical trial design using
               orthotopic and genetically engineered model systems
Room           Laboratories Gastroenterology and Gastrointestinal Oncology

               Theory and Hands-on Training
               R. Goetze (Göttingen)

08:30–12:30    Workshop 4 l Präparierkurs Pankreaskopfresektion
Room           Anatomy of the University Hospital Göttingen

               Hands-on Training
               J. Gaedcke (Göttingen)

10:30–12:30    PASS 1-2 Trials Meeting
Room           Lecture Theater 552

6
WISSENSCHAFTLICHES PROGRAMM I DONNERSTAG, 7. FEBRUAR
                                 SCIENTIFIC PROGRAMME I THURSDAY, 7 FEBRUARY

13:30–14:00   Welcome session
Room          Adam-von-Trott-Saal
              Welcome note of the conference chair
              A. Neeße (Göttingen)

              Welcome note of the DGIM secretary general
              U. R. Fölsch (Kiel)

14:00–15:30   Session 1 I Clinical and translational pancreatology
Room          Adam-von-Trott-Saal
Chairs        U. Wittel (Freiburg), I. E. Demir (Munich)

14:00         Keynote I Walter Halangk memorial lecture
              The German Pancreas Club will honor the memory of Walter Halangk
              (longtime secretary of the DPC) with a Walter Halangk memorial lecture by
              J. Mayerle (Munich)

14:18         Neoadjuvant treatment for locally advanced pancreatic cancer – prognostic
              factors of survival
              U. Klaiber, E. S. Schnaidt, U. Heger, M. Sachsenmaier, U. Hinz, O. Strobel
              M. W. Büchler, T. Hackert (Heidelberg)

14:26         Targeting DNA damage response by establishing synergistic therapeutic
              routes in DDR deficient pancreatic cancer
              L. Perkhofer, J. Gout, M. Morawe, F. Arnold, P.-O. Frappart, A. Kleger (Ulm)

14:34         Theranostic targeting of pancreatic cancer cells using CD44 variant
              6-specific aptamers
              J. Peterhansl, U. M. Mahajan, E. Osterode, K. Lauber, Qi. Li, I. Regel
              J. Mayerle (Munich)

14:42         Keynote I Metabolism in pancreatic diseases – To fast or not to fast!
              H. Algül (Munich)

15:00         Prognostic impact of tumor-infiltrating leukocytes on survival of patients
              with primary resected pancreatic cancer
              R. C. Miksch, M. Weniger, S. Ormanns, J. Werner, A. V. Bazhin
              J. G. D’Haese (Munich)

15:08         P90-RSK as a synthetic lethal target in pancreatic cancer – molecular
              characterisation and therapeutic inhibition
              J. Riedel (Halle a. d. Saale), N. Milosevic (Gießen), J. von Kries
              M. Nazare (Berlin), H. Griesmann, P. Michl (Halle a. d. Saale)

15:16         Locally advanced and borderline-resectable pancreatic adenocarcinoma:
              neoadjuvant FOLFIRINOX as part of a multimodal strategy with curative
              intention
              S. Acciuffi, J. Omari, R. Drewes, D. Jechorek, R. Croner, H. Ptok (Magdeburg)

                                                                                             7
WISSENSCHAFTLICHES PROGRAMM I DONNERSTAG, 7. FEBRUAR
SCIENTIFIC PROGRAMME I THURSDAY, 7 FEBRUARY

15:45–17:15   Poster sessions 1–3 (please see pages 17–21)

17:30–19:00   Session 2 I Pancreatitis and pancreatic cancer – clinical and basic science
Room          Adam-von-Trott-Saal
Chairs        R. Jaster (Rostock), G. von Figura (Munich)

17:30         Keynote I Autoimmune pancreatitis and the UEG guideline effort
              J. Rosendahl

17:48         Clinical significance of immunosuppressive therapy with tacrolimus in
              IgG4-related autoimmune pancreatitis – our experience in a cohort of 71
              patients
              A. Kahraman, M. Büchter, G. Gerken (Essen)

17:56         Foxp3+/CD25+ regulatory T cells influence the T-cell response and systemic
              inflammation in a mouse model of acute pancreatitis
              J. Glaubitz, A. Wilden, C. van den Brandt, F. U. Weiß (Greifswald)
              J. Mayerle (Munich), M. M. Lerch, M. Sendler (Greifswald)

18:04         The Axon Guidance Receptor ROBO3 mediated transcriptional regulation
              links to pancreatic cancer plasticity
              N. Krebs, S. Önder, X. Xu, J. M. Güntner, M. Tu, V. Ellenrieder
              S. K. Singh (Göttingen)

18:12         PPDPF impacts human pancreatic progenitor cell formation
              M. Breunig, M. Hohwieler, N. Zhang (Ulm), J. Glöckner (Tübingen)
              T. Seufferlein (Ulm), S. Liebau (Tübingen), A. Kleger (Ulm)

18:20         Oncogenic network analysis of ALDH1A3-positive pancreatic ductal
              adenocarcinoma
              M. Shi, J. Cao, J. Akkan, N. Maeritz, G. O. Ceyhan, H. Friess (Munich)
              C. Michalski, J. Kleeff (Halle a. d. Saale), B. Kong (Munich)

18:28         Epigenetic modifications distinguish between the classical and basal
              pancreatic cancer subtype
              S. Pichlmeier, A. Kirmayr, S. Benitz, U. M. Mahajan, L. Fahr (Munich)
              C. Michalski, J. Kleeff (Halle a. d. Saale), J. G. D’Haese, J. Mayerle
              I. Regel (Munich)

18:36         Keynote I Why surgical treatment for chronic pancreatitis patients is so
              important
              G. O. Ceyhan (Istanbul/TR)

19:30–21:30   Get together (please see page 27)

8
WISSENSCHAFTLICHES PROGRAMM I FREITAG, 8. FEBRUAR
                                      SCIENTIFIC PROGRAMME I FRIDAY, 8 FEBRUARY

08:30–10:00   Session 3 I Pancreatic surgery
Room          Adam-von-Trott-Saal
Chairs        J. Kleeff (Halle a. d. Saale), J. Gaedcke (Göttingen)

08:30         Keynote I Opportunities and limits of minimally invasive pancreatic
              surgery
              T. Keck (Lübeck)

08:48         Long-term overall survival and prognostic factors after
              pancreatoduodenectomy for ampullary cancer – analysis of a large
              multicenter cohort of more than 200 patients
              L. Bolm, K. Ohrner (Lübeck), F. Rückert (Mannheim)
              B. M. Rau (Neustadt i. d. Oberpfalz), E. Petrova, D. Bausch (Lübeck)
              J. Weitz (Dresden), T. Keck, U. Wellner (Lübeck), M. Distler (Dresden)

08:56         An R0-resectable, genetically engineered mouse model of pancreatic
              cancer mimics the response to neoadjuvant chemotherapy in human PDAC
              C. Mota-Reyes (Munich), B. Mundt, J. Brooks (Hannover), B. Konukiewitz
              A. Muckenhuber, S. Teller, W. Weichert (Munich), F. Kühnel (Hannover)
              H. Friess, G. O. Ceyhan, I. E. Demir (Munich)

09:04         Volume outcome relationship in pancreatic surgery – effects of hospital and
              surgeon volume on mortality and postoperative pancreatic fistula
              S. Acciuffi, H. Ptok (Magdeburg), I. Gastinger (Cottbus)
              R. Croner (Magdeburg), H. Dralle (Essen)

09:12         Keynote I Career options for young surgeons – Clinic, science or both?
              C. Michalski (Halle a. d. Saale)

09:30         Trans-parenchymatous sutures cause substantial and persistent
              inflammation in mouse pancreas
              C. Kühlbrey, A. Zabadne, U. Wittel (Freiburg)

09:38         Patterns of recurrence after resection of pancreatic ductal adenocarcinoma
              in the ESPAC-4 Trial
              J. Neoptolemos, T. Hackert, C. Tjaden (Heidelberg), R. Jones, E. Psarelli
              R. Jackson, P. Ghaneh, C. Halloran, D. Palmer (Liverpool/GB), O. Strobel
              M. Buchler (Heidelberg)

09:46         Activated stroma index in neoadjuvantly treated patients with pancreatic
              ductal adenocarcinoma
              A. Martens, U. Heger, B. Walter, H. Sun, S. Roth (Heidelberg)
              C. Michalski (Halle a. d. Saale), M. W. Büchler, T. Hackert (Heidelberg)

                                                                                         9
WISSENSCHAFTLICHES PROGRAMM I FREITAG, 8. FEBRUAR
SCIENTIFIC PROGRAMME I FRIDAY, 8 FEBRUARY

10:15–12:00   Session 4 I Clinical trials and novel therapies
Room          Adam-von-Trott-Saal
Chairs        V. Ellenrieder (Göttingen), C. Bruns (Cologne)

10:15         Keynote I Immuno-oncology – the basics and future perspectives
              H. Flach (Munich)

10:45         In-depth molecular characterisation of pancreatic ductal adenocarcinoma
              based on patient-derived tumor organoids
              S. Le Blanc, T. Bauer (Heidelberg), N. Ishaque (Berlin), S. Schuth, A.-K. König
              M. Volkmar, C.-S. Leonhardt, J. Jabs, U. Toprak, M. Schenk, N. Giese
              R. Offringa, C. Conrad, M. W. Büchler, M. Schlesner (Heidelberg)
              R. Eils (Heidelberg, Berlin), O. Strobel (Heidelberg)

10:53         Keynote I Future clinical trial concepts in PDAC
              J. Siveke (Essen)

11:23         Reliability of determining the resectability of locally progressed pancreatic
              ductaladenocarcinomas – results from the CONKO-007 multicenter
              randomised controlled trial (EudraCT:2009-014476-21)
              U. Wittel (Freiburg), H. Golcher, R. Grützmann (Erlangen)
              W. Bechstein (Frankfurt), O. Belyaev, W. Uhl (Bochum)
              M. Ghadimi (Göttingen), U. Hopt (Freiburg), A. Pirkl, D. Lubgan
              W. Hohenberger (Erlangen), H. Oettle (Friedrichshafen), R. Fietkau (Erlangen)

11:31         Comparative characterisation and epigenetic/metabolic targeting of
              primary 2D and 3D cultured PDAC cells
              S.-T. Liffers, S. Mergener, A. Winkelkotte, M. Trajkovic-Arsic, S. S. Lueong
              J. Forster (Essen), S. Hahn (Bochum), J. Siveke (Essen)

11:39         Keynote l PASS1/2 trial
              J. Neoptolemos (Heidelberg)

11:47–12:30   Coffee break and visit of the industrial exhibition

12:00–12:15   AG Pankreas Meeting

12:30–14:00   Poster sessions 4–6 (please see pages 22–26)

12:45–13:45   Student meeting Professor Ghadimi

10
WISSENSCHAFTLICHES PROGRAMM I FREITAG, 8. FEBRUAR
                                      SCIENTIFIC PROGRAMME I FRIDAY, 8 FEBRUARY

14:00–15:00   Session 5 I Endoscopy
Room          Adam-von-Trott-Saal
Chairs        A. Hoffmeister (Leipzig), A. Arlt (Kiel)

14:00         Value of EUS guided drainage in the management of postoperative
              pancreatic fistulas and fluid collections – a retrospective multi center analysis
              M. Distler (Dresden), C. Jürgensen (Berlin), A. Arlt (Kiel)
              S. Brückner (Dresden), M. Ellrichmann (Kiel), K. Matthes (Dresden)
              M. Ludwig (Berlin), S. Sulk, L. Romberg, S. Zeissig (Dresden)
              C. Schafmayer, S. Hinz (Kiel), T. Welsch (Dresden), M. Bahra (Berlin)
              H. Aselmann (Kiel), J. Weitz (Dresden), F. Klein (Berlin), T. Becker (Kiel)
              J. Hampe (Dresden)

14:08         Endoscopic necrectomy of the infected WON – development of an
              effective therapy algorithm on the basis of a monocentric population
              K. Jäger, F. Füldner (Gera), F. Meyer (Magdeburg), U. Will (Gera)

14:16         Keynote l Current standards and controversies in the endoscopic
              treatment of pancreatic necroses
              J. Hampe (Dresden)

14:34         Comparative characterisation of postoperative pancreatic fistula according
              to the 2005 and 2016 definitions of the International Study Group for
              Pancreatic Surgery
              E. Petrova, L. Bolm, H. Lapshyn, C. Busch, L. Frohneberg, S. Deichmann
              K. C. Honselmann, D. Bausch, T. Keck, U. Wellner (Lübeck)

14:42         Keynote l EUS – Interventionen bei benignen und malignen Erkrankungen
              des Pankreas – Möglichkeiten und Grenzen
              U. Will (Gera)

14:51–15:15   Coffee break and visit of the industrial exhibition

                                                                                            11
WISSENSCHAFTLICHES PROGRAMM I FREITAG, 8. FEBRUAR
SCIENTIFIC PROGRAMME I FRIDAY, 8 FEBRUARY

15:15–17:00   Session 6 I Pancreatic cancer – clinical and translational research
Room          Adam-von-Trott-Saal
Chairs        M. Ghadimi (Göttingen), R. Schmid (Munich)

15:15         Keynote l Medical therapy of pancreatic ductal adenocarcinomas
              A. König (Göttingen)

  Oxford discussion l surgery for oligo-metastatic pancreatic cancer patients
15:36
  1. Opening statement pro vs. contra surgery for oligometastatic PDAC
		 5min for each speaker
  2. Question time for both chairs  – 3min for each speaker
  3. Exchange of questions between the speakers (3–5min)
  4. Question time for the audience (max 5min)
  5. Final statements from the speakers – 2min for each speaker
  6. Audience vote
  S. Kersting (Erlangen), T. Seufferlein (Ulm)

16:06         The role of GSK3β in chromatin plasticity and DNA damage repair mechanisms
              G. E. Schmidt, K. Reutlinger, L. Augustin, M. C. Hasselluhn, A. Tirilomi
              E. Hessmann, S. A. Johnsen, V. Ellenrieder (Göttingen)

16:14         The interaction of tumor and stroma via the IL-17B/RB axis affects
              metastatic potential of pancreatic ductal adenocarcinoma
              J. Li, Q. Sun, J. Zhao, Z. Wang, J. Qin, X. Wu, C. Bruns, Yu. Zhao
              F. Popp (Cologne)

16:22         The clinical relevance of a novel matrisome signature in PDAC
              K. C. Honselmann (Lübeck; Boston, MA/US), Dan. Birnbaum (Marseille/FR)
              S. Begg, P. Finetti, Dav. Birnbaum, F. Bertucci, D. Ting, E. Tai, C. Monsalve
              M. Mino- Kenudson, K. Lillemoe, C. Fernandez-del Castillo, A. Warshaw
              A. Liss (Boston, MA/US)

16:30         Identification of superior combinatorial PDA therapies involving cytostatic
              agents and immunostimulatory antibodies in a clinically relevant mouse
              model
              D. Baumann, J. Mochayedi, T. Hägele, J. Drebant, C. Vent, I. Poschke
              M. Volkmar, R. Offringa (Heidelberg)

16:38         Tumor exosomes modulate progression of PDAC and distant metastasis
              S. Polaschek, T. Eiseler, T. Seufferlein (Ulm)

12
WISSENSCHAFTLICHES PROGRAMM I FREITAG, 8. FEBRUAR
                                      SCIENTIFIC PROGRAMME I FRIDAY, 8 FEBRUARY

16:46         Utilising patient-derived organoids from endoscopic fine needle aspiration
              as a diagnostic tool and research platform for personalised medicine in
              pancreatic ductal adenocarcinoma
              Z. Dantes, H.-Y. Yen, K. Steiger, A. Muckenhuber, N. Pfarr, C. Winter
              T. Engleitner, S. Lange, R. Öllinger, I. Heid, K. Shi, K. Peschke, K. Feldmann
              C. Lubeseder-Martellato, M. Martignoni, G. O. Ceyhan, H. Friess, A. Herner
              L. Liotta, M. Treiber, G. von Figura, M. Abdelhafez, P. Klare
              C. Schlag (Munich), J. Siveke (Essen), R. Braren, W. Weichert, D. Saur
              R. Schmid, R. Rad, G. Schneider, M. Reichert (Munich)

16:54–17:15   Coffee break and visit of the industrial exhibition

17:15–18:30   Session 7 I Acute and chronic pancreatitis
Room          Adam-von-Trott-Saal
Chairs        J. Rosendahl (Halle a. d. Saale), J. Mayerle (Munich)

17:15         Myeloid derived suppressor cell (MDSCs) differentiation during acute
              pancreatitis regulates the systemic immune response
              A. Wilden, J. Glaubitz, J. Golchert, G. Homuth, F. U. Weiß (Greifswald)
              J. Mayerle (Munich), M. Sendler, M. M. Lerch (Greifswald)

17:23         Mast cell stabilisers ameliorate pain in experimental chronic pancreatitis
              S. Klauss, S. Schorn, S. Teller, H. Friess, G. O. Ceyhan, I. E. Demir (Munich)

17:31         Keynote I Pancreatitis in patients with lipid disorders
              M. M. Lerch (Greifswald)

18:01         Gender-dependent mechanisms of autophagy in the transition of acute to
              chronic pancreatitis
              K. Diakopoulos, A. Berninger, M. Kowalska, K. Görgülü, M. Lesina, J. Ai
              A.-F. Karpathaki, D. Kabacaoglu, K. J. Ciecielski, E. Kaya-Aksoy, R. Schmid
              H. Algül (Munich)

18:09         Pancreatic autophagy attenuates endotoxin-induced pancreatic injury
              L. Xia, T. Hackert, F. Fortunato (Heidelberg)

18:17         Absence of LMP7 immunoproteasome subunit leads to delayed organ
              recovery after acute pancreatitis
              L. De Freitas Chama, F. U. Weiß, F. Ebstein, E. Krüger, M. M. Lerch
              M. Sendler (Greifswald)

18:30–19:30   General assembly
Room          Adam-von-Trott-Saal

20:00         Conference dinner and award ceremony at the Freizeit In Hotel
              (please see page 27)

                                                                                               13
WISSENSCHAFTLICHES PROGRAMM I SAMSTAG, 9. FEBRUAR
SCIENTIFIC PROGRAMME I SATURDAY, 9 FEBRUARY

08:30–09:45   Session 8 I Neuroendocrine tumors
Room          Adam-von-Trott-Saal
Chairs        J. Werner (Munich), S. Krug (Halle a. d. Saale)

08:30         C-reactive protein (CRP) is associated with poor prognosis by promoting
              growth signaling pathway activation in pancreatic neuroendocrine neo
              plasms
              S. Schimmack, Y. Yang, F. Bergmann, K. Felix, T. Hackert
              O. Strobel (Heidelberg)

08:38         Cause of death in patients with pancreatic neuroendocrine neoplasms
              (pNEN) – analysis of 6465 cases in the surveillance, epidemiology, and end
              results (SEER) database
              L. P. Breitling, A. Rinke, T. Gress (Marburg)

08:46         Keynote I New German S2K guideline for neuroendocrine tumours:
              „What is new for PNENs?”
              T. Gress (Marburg)

09:04         Primary pancreatic tumor resection results in superior overall and
              prolonged progression free survival after peptide receptor radionuclide
              therapy in advanced neuroendocrine neoplasms
              D. Kämmerer (Bad Berka), M. Twrznik (Mühlhausen), D. Hörsch
              R. P. Baum, M. Hommann (Bad Berka)

09:12         Keynote l Surgery for pancreatic neuroendocrine tumors – which
              operation for which patient
              O. Strobel (Heidelberg)

09:30         Mir-132 controls beta cell proliferation and survival in mouse
              model through the PTEN/AKT/FOXO3 signaling
              S. Kersting (Erlangen), H. Mziaut (Dresden), M. Solimena (Erlangen, Dresden)

09:38         Pathology has the last word – pancreatic fibrosis is a better parameter for
              prediction of pancreatic fistula than texture – a retrospective analysis from
              the RECOPANC Trial
              E. Petrova (Lübeck), S. Timme, M. Werner (Freiburg), T. Keck (Lübeck)
              P. Bronsert (Freiburg), U. Wellner (Lübeck)

09:46–10:00   Coffee break and visit of the industrial exhibition

14
WISSENSCHAFTLICHES PROGRAMM I SAMSTAG, 9. FEBRUAR
                                 SCIENTIFIC PROGRAMME I SATURDAY, 9 FEBRUARY

10:00–11:45   Session 9 l Tumor microenvironment, stem cells and epigenetics
Room          Adam-von-Trott-Saal
Chairs        I. Regel (Munich), E. Hessmann (Göttingen)

10:00         Keynote I Pancreatic cancer
              D. Tuveson (Cold Spring Harborg, NY/US)

10:30         Immune infiltration patterns in genetically engineered mouse models of
              pancreatic cancer largely depend on the age and only partly reflect the
              human disease
              O. Safak, I. E. Demir, S. Wang, I. Gürcinar, B. Yilmaz, C. Mota-Reyes, H. Friess
              G. O. Ceyhan (Munich)

10:38         Characterisation of p53-dependent oncogenic EZH2-activity in pancreatic
              cancer
              L. Versemann, H. Witte, W. Kopp, J. Spitalieri, X. Xu, V. Ellenrieder
              E. Hessmann (Göttingen)

10:46         Bulk and single-cell T-cell receptor and transcriptome profiling reveals
              significant phenotypic, spatial and temporal heterogeneity in the
              tumor-infiltrating lymphocyte repertoire of pancreatic cancer and
              melanoma patients
              I. Poschke, C. L. Tan, I. Heras-Murillo, K. Lindner, A. Rodrizuez-Ehrenfried
              L. Appel, K. König, M. W. Büchler (Heidelberg), U. Sahin (Mainz), J. Hassel
              O. Strobel (Heidelberg), M. Flossdorf (Munich), R. Offringa (Heidelberg)

10:54         Keynote I Stem cells and their application in pancreatic cancer research
              A. Kleger (Ulm)

11:12         Site-specific angiogenesis may promote isolated pulmonary metastasis in
              pancreatic cancer
              T. Krauss, S. Teller, H. Friess, G. O. Ceyhan, I. E. Demir (Munich)

11:20         Analysing molecular regulation in pancreatic cancer based on (i) the
              interaction of tumour and its peritumoral tissue, (ii) intercellular
              communication within the tumour microenvironment and (iii) intracellular
              methylation changes in tumour-relevant gene promoters
              J. D. Hoheisel, M. S. S. Alhamdani (Heidelberg), E. A. Moskalev (Erlangen)
              A. S. Bauer, Ye. Wu, N. Giese, T. Hackert, O. Strobel
              M. W. Büchler (Heidelberg)

11:28         Identification of DNA mutations in pancreatic stellate cells
              V. Böker, J. Kleeff (Halle a. d. Saale)

                                                                                             15
WISSENSCHAFTLICHES PROGRAMM I SAMSTAG, 9. FEBRUAR
SCIENTIFIC PROGRAMME I SATURDAY, 9 FEBRUARY

12:00–13:30   Session 10 I Cystic lesions and precursor lesions of the pancreas
Room          Adam-von-Trott-Saal
Chairs        I. Esposito (Düsseldorf), D. Bausch (Lübeck)

12:00         A coherent roadmap to generate pancreatic duct-like cells from human
              pluripotent stem cells to model plasticity and dysplasia in the pancreas
              M. Hohwieler, M. Breunig, J. Merkle, S. Heller, T. Seufferlein, P.-O. Frappart
              A. Kleger (Ulm)

12:08         mTORC1 and mTORC2 converge at the Arp 2/3 complex-mediated actin
              cytoskeleton regulation in promoting ADM formation
              Ya. Zhao, V. Tissen, L. Chang, J. G. D’Haese, S. Raulefs, J. Qin, J. Akkan, Y. Yu
              Z. Zhang, J. Cao, S. Benitz, G. O. Ceyhan, H. Friess, B. Kong (Munich)

12:24         Keynote I Cystic lesions of the pancreas – clinical impact and molecular
              insights
              P. Michl (Halle a. d. Saale)

12:16         Sensitive and specific identification of mutanome-encoded T-cell epitopes
              in PDAC on the basis of xenograft NGS data using a hybrid reference
              genome
              M. Volkmar (Heidelberg), D. Hoser (Berlin), C. Lauenstein, J. Rebmann
              A. Hotz-Wagenblatt, J. Rieger, I. Poschke, M. Sprick, A. Trumpp
              M. Büchler, O. Strobel (Heidelberg), G. Willimsky (Berlin)
              R. Offringa (Heidelberg)

12:42         Ablation of Hnf1b in adult pancreatic acinar cells inhibits precancerous
              lesions in mice
              S. Zhong, A. Hidalgo Sastre, G. von Figura (Munich)

12:50         Functional and mechanistic implications of ARID1A-deficiency in pancreatic
              metaplasia and PDAC initiation
              Z. Zhang, W. Kopp, H. Bohnenberger, Xin. Wang, F. Hamdan, M. Sen
              L. Aperdannier, S. A. Johnsen, E. Hessmann (Göttingen)

12:58         Effects of RSK3 modulation on autophagy and metabolism in pancreatic
              cancer
              B. B. K. Dinh, J. Riedel, H. Griesmann, P. Michl (Halle a. d. Saale)

13:06         Keynote I Pancreatic cyst surgery – Oncological, parenchyma sparing,
              minimally invasive?
              T. Hackert (Heidelberg)

13:30–14:00   Farewell and invitation to Halle
Room          Adam-von-Trott-Saal
              C. Michalski, S. Krug (Halle a. d. Saale)

16
POSTERSPRÄSENTATIONEN I DONNERSTAG, 7. FEBRUAR
                                          POSTER SESSIONS I THURSDAY, 7. FEBRUARY

15:45–17:15   Poster session 1 I Tumor biology and therapy
Room          Terminal 1
Chairs        L. Perkhofer (Ulm), R. Schulz-Heddergott (Göttingen)

P 01          Crosstalk between IGF2BP RNA-binding proteins and epigenetic regulators
              in pancreatic neuroendocrine tumors
              F. Sperling, L. Nietfeld, S. Hüttelmaier, P. Michl, H. Griesmann (Halle a. d. Saale)

P 02          Role of PAI-1 in cell-proliferation and metastasis of pancreatic carcinoma cells
              Q. Wang, A. Rech, F. Seyfried, E. Birgin, F. Rückert, P. Pallavi (Mannheim)

P 03          Evaluation of the effect of cancer-associated fibroblasts on the response of
              pancreatic cancer organoids to drug treatment in a 3D coculture model
              S. Schuth, S. Le Blanc, J. Jabs, M. Schenk, N. Giese, R. Offringa, C. Conrad
              O. Strobel (Heidelberg)

P 04          Pancreatic cancer cells access nerves via TGFbeta1-mediated
              transdifferentiation of perineural epithelial cells into mesenchymal-like cells
              I. E. Demir, U. Bourquain, S. Teller, E. Krohmer, D. Saur, H. Friess
              G. O. Ceyhan (Munich)

P 05          Vitamin D modulates proliferation, migration and activation of pancreatic
              stellate cells and tumor-stroma crosstalk
              Ya. Wu, Qu. Li, M. Weniger, M. Ilmer, J. Werner, A. V. Bazhin
              J. G. D’Haese (Munich)

P 06          Intratumoral T cell dysfunction in a murine model of pancreatic cancer
              E. Nasiri, A. Hanlon, V. Lutz, E. Landmann, M. Huber, M. Buchholz, T. Gress
              C. Bauer (Marburg)

P 07          Immune regulation properties of sulforaphane in pancreatic cancer
              Y. Wang, A. Wieland, E. Petrikova, J. Gladkich, W. Groß, N. Gretz, I. Herr
              S. Karakhanova (Heidelberg)

P 09          Glyoxalase-I – A novel target for pancreatic cancer?
              M. Hollenbach, J. Lorenz, I. Sommerer, S. Sonnenberg, P. Reichwald
              J. Mössner (Leipzig), J. Rosendahl, P. Michl (Halle a. d. Saale)
              A. Hoffmeister (Leipzig)

                                                                                              17
POSTERSPRÄSENTATIONEN I DONNERSTAG, 7. FEBRUAR
POSTER SESSIONS I THURSDAY, 7. FEBRUARY

P 10          An immunohistochemical analysis of heat shock protein 27 in pancreatic
              ductal adenocarcinoma
              R. Drexler, K.-J. Oldhafer, K.-C. Wagner, M. Küchler (Hamburg)

P 12          The serine/threonine kinase FASTK is overexpressed in pancreatic ductal
              adenocarcinoma and its downregulation inhibits growth in 2D and 3D cell
              models
              M. Tatura, T. Gress, M. Buchholz (Marburg)

P 13          Characterising inflammatory signaling pathways in ARID1a-deficient PDAC
              subtypes
              L. Aperdannier, E. Hessmann (Göttingen)

15:45–17:15   Poster session 2 I Surgery
Room          Terminal 2
Chairs        J. G. D’Haese (Munich), U. Wellner (Lübeck)

P 14          Preoperative biliary stenting is associated with higher postoperative
              morbidity and equivalent mortality in patients with hyperbilirubinemia:
              an analysis of the German DGAV StuDoQlPancreas registry
              L. Bolm, E. Petrova, L. Woehrmann (Lübeck), J. Werner (Munich)
              W. Uhl (Bochum), N. Nuessler (Munich), M. Ghadimi (Göttingen)
              D. Bausch, H. Lapshyn (Lübeck), J. Gaedcke (Göttingen)
              O. Belyaev (Bochum), J. G. D‘Haese, T. Klier (Munich), T. Keck
              U. Wellner (Lübeck)

P 15          Metastatic renal cell carcinomas target the fatty pancreas
              T. Fahlbusch, W. Uhl, C. Braumann (Bochum)

P 16          Natural history and treatment of solid-pseudopapillary tumors of the
              pancreas – a population based study of 100 patients and review of the
              literature
              M. Renz (Nuremberg)

P 17          Human tissue related kallikreins as potential biomarker and prognostic
              variable in pancreatic cancer
              J. Eberhard (Mannheim), A. Soosaipillai (Toronto/CA)
              C. Reissfelder (Mannheim), E. P. Diamandis (Toronto/CA)
              F. Rückert (Mannheim)

18
POSTERSPRÄSENTATIONEN I DONNERSTAG, 7. FEBRUAR
                                  POSTER SESSIONS I THURSDAY, 7. FEBRUARY

P 18   Drainage management in patients receiving pancreatic head resection:
       a single center analysis in the wake of the PANDRA trial
       E. Rasbach, C. Reissfelder, F. Rückert (Mannheim)

P 19   The presence of special bacteria at the time of surgery seems to increase
       the rate of postoperative complications after pancreas surgery
       E. A. Biesel, P. Weyhmüller, O. Sick, F. Makowiec, U. Hopt, S. Fichtner-Feigl
       U. Wittel (Freiburg)

P 20   Alternative approach using CT-guided percutaneous injection of thrombin
       foam in recurrent bleeding into a pseudocyst due to acute pancreatitis and
       simultaneous aortic dissectio
       C. Wex (Magdeburg), J. Jürgens (Hamburg), J. Schiefer (Magdeburg)
       O. Dudeck (Zurich/CH), J. Rabczak, F. Meyer (Magdeburg)

P 21   Prognostic factors of survival in 196 patients undergoing
       duodeno-pancreatectomy for distal bile duct cancer
       C. Tjaden, U. Klaiber, U. Hinz, O. Strobel, J. Neoptolemos, M. W. Büchler
       T. Hackert (Heidelberg)

P 22   Inflammatory myofibroblastic tumor of the pancreas – case report and a
       review of the literature
       M. Sorleto, S. Elhabash, M. Alnabki, I. Dimopoulus, R. Sekhri, C. Gartung
       B. Gerdes (Minden)

P 23   Delayed gastric emptying does not influence cancer specific survival after
       pancreatoduodenectomy for pancreatic adenocarcinoma
       T. R. Glowka, J. Hafke, S. Manekeller, J. C. Kalff (Bonn)

P 24   Clinical presentation and outcome of adenosquamous carcinoma of the
       pancreas – a matched pair analysis to pancreatic ductal adenocarcinoma
       J. Kaiser, U. Hinz, T. Hank, W. Niesen, D. Jäger, T. Hackert, M. W. Büchler
       O. Strobel (Heidelberg)

P 48   Ezh2 controls PDAC plasticity by regulating differentiation genes
       S. Patil, Z. Najafova, V. Kari, B. Steuber, H. Bohnenberger, W. Kopp
       A. Neesse, V. Ellenrieder, S. A. Johnsen, E. Hessmann (Göttingen)

                                                                                     19
POSTERSPRÄSENTATIONEN I DONNERSTAG, 7. FEBRUAR
POSTER SESSIONS I THURSDAY, 7. FEBRUARY

15:45–17:15   Poster session 3 I Inflammation and carcinogenesis
Room          Terminal 3
Chairs        G. Beyer (Munich), S. K. Singh (Göttingen)

P 26          The role of IL-18 in pancreatic fibrosis
              Z. Li, M. Weniger, J. Werner, A. V. Bazhin, J. G. D’Haese (Munich)

P 27          Autoimmune pancreatitis type 1 associated with a pancreatic pseudocyst
              F. Hesse, R. Braren, R. Schmid, V. Philipp (Munich)

P 28          Regulation of transcription factors in the ER stress recognition system
              during acute pancreatits
              R. Bolsmann, F. U. Weiß (Greifswald), J. Mayerle (Munich), M. M. Lerch
              M. Sendler (Greifswald)

P 29          IRAK-M regulates local and systemic immune responses in acute
              pancreatitis
              F. Thiel, F. U. Weiß, M. M. Lerch, M. Sendler (Greifswald)

P 30          An in vitro system to evaluate potential therapeutic substances for ER stress
              reduction during pancreatitis
              J. M. Modenbach, F. U. Weiß (Greifswald), M. Gronbach, C. Oppermann
              F. El-Hage, J. Pospech (Rostock), M. M. Lerch, M. Sendler (Greifswald)

P 31          The influence of receptors for advanced glycation end products (AGE-R´s)
              and advanced glycation end products (AGE”s) in patients suffering from
              chronic pancreatitis
              N. Hesselbarth, R. Böhme, C. Böhme, P. Michl, J. Rosendahl (Halle a. d. Saale)

P 32          Role of receptors for advanced glycation end products in development of
              pancreatitis and pancreatic cancer
              R. Böhme, N. Hesselbarth, P. Michl, J. Rosendahl (Halle a. d. Saale)

P 33          Betacellulin protective effects against experimental acute pancreatitis are
              ERBB4-dependent
              K. Hedegger, H. Algül, M. Lesina, M. Schneider, M. Dahlhoff (Munich)

P 34          TLR3 is required for pancreatic regeneration
              A. Hidalgo Sastre, L. Jochheim, K. Steiger, R. Schmid, B. Holzmann
              G. von Figura (Munich)

20
POSTERSPRÄSENTATIONEN I DONNERSTAG, 7. FEBRUAR
                                                             POSTER SESSIONS I THURSDAY, 7. FEBRUARY

                           P 35   Efficacy and safety of lumen-apposing metal stents for the drainage of
                                  pancreatic fluid collections in a large retrospective multicenter analysis
                                  S. Zeissig, S. Sulk, S. Brückner, R. Schmelz, J. Babatz, M. Berning, C. Kirsch
                                  S. Pannach, K. Matthes, M. Hohmann (Dresden), S. Reichel (Gera)
                                  M. Ellrichmann, A. Arlt (Kiel), U. Will (Gera), J. Hampe (Dresden)

                           P 36   Different characteristics of dibutyltin dichloride-induced chronic
                                  pancreatitis and hepatitis in mouse and rat
                                  F. Lütt, H. Nizze, R. Jaster (Rostock)

                           P 37   Hippo regulates proliferation and matrix protein synthesis of pancreatic
                                  stellate cells
                                  L. Spanehl, R. Jaster (Rostock)

                           P 38   Intrapancreatic zymogen activation in response to autophagy modulation in
                                  caerulein hyperstimulated mice
                                  T. Wartmann, H. Faber-Zuschratter, F. Meyer (Magdeburg), K. Diakopoulos
                                  H. Algül, J. Mayerle (Munich), M. M. Lerch (Greifswald), W. Halangk
                                  R. Croner (Magdeburg)

                                                                                                  www.conventus.de
© Nejron Photo / Fotolia

                                                                                Success through
                                                                                             versatile
                                                                                             solutions

    As a full-service PCO, we provide you with
    intelligent and innovative solutions in an advisory
    and implementing manner.
                                                                                                                   21
POSTERSPRÄSENTATIONEN I FREITAG, 8. FEBRUAR
POSTER SESSIONS I FRIDAY, 8. FEBRUARY

12:30–14:00   Poster session 4 I Molecular mechanisms and novel therapies in PDAC
Room          Terminal 1
Chairs        M. Sendler (Greifswald), H. Griesmann (Halle a. d. Saale)

P 39          The role of BRD3 in pancreatic ductal adenocarcinoma
              A. P. Kutschat, F. Hamdan, Xin. Wang, S. A. Johnsen (Göttingen)

P 40          Cellular immunotherapy for pancreatic cancer – evaluation of novel target
              candidates
              D. Schäfer (Bergisch Gladbach, Göttingen), L. N. Küster, S. Tomiuk
              A. Bosio (Bergisch Gladbach), J. Missbach-Güntner, D. Pinkert-Leetsch
              F. Alves (Göttingen), O. Hardt (Bergisch Gladbach)

P 41          Impact of Tlr3 on acinar-to-ductal metaplasia and pancreatic cancer
              progression
              S. Benitz, L. Fahr, J. Mutter, H. Lisiecki (Munich), J. Kleeff (Halle a. d. Saale)
              I. Esposito (Düsseldorf), J. Mayerle (Munich), C. Michalski (Halle a. d. Saale)
              I. Regel (Munich)

P 42          Uncovering the role of ERBB receptors in pancreatic ductal adenocarcinoma
              upon betacellulin-induced signaling in mice
              K. Hedegger, H. Algül, M. Lesina, M. Schneider, M. Dahlhoff (Munich)

P 43          Sulforaphane enhances gemcitabine cytotoxicity in pancreatic cancer
              through downregulation of miR-30a-3p
              C. Georgikou, L. Yin, J. Gladkich, X. Xiao (Heidelberg), C. Sticht
              C. De La Torre (Mannheim), W. Groß (Heidelberg), N. Gretz (Mannheim)
              S. Karakhanova, I. Herr (Heidelberg)

P 44          Metabolic profiling and targeting of pancreatic ductal adenocarcinoma
              S. Karakaya, A. Winkelkotte, S.-T. Liffers, S. S. Lueong (Heidelberg, Essen)
              M. Matzka, M. Aichler, A. Walch (Munich), W. Yang, A. Harms
              T. Hankemeier (Leiden/NL), S. Hahn (Bochum) M. Trajkovic-Arsic
              J. Siveke (Essen, Heidelberg)

P 45          Generation and development of a novel dual bet/hdac inhibitor with
              promising anti-tumor properties
              X. Zhang, T. Zegar (Essen), R. Lucas, T. Weiser (Frankfurt)
              M. Trajkovic-Arsic (Essen), M. Remke (Düsseldorf), S. Mergener (Essen)
              S. Knapp (Frankfurt), J. Siveke (Essen)

22
POSTERSPRÄSENTATIONEN I FREITAG, 8. FEBRUAR
                                               POSTER SESSIONS I FRIDAY, 8. FEBRUARY

P 46          Characterisation of immune-based mechanisms in pancreatic ductal adeno
              carcinoma
              C. Neander, M. Trajkovic-Arsic, S.-T. Liffers, P. F.-Y. Cheung, J. Siveke (Essen)

P 47          Combined treatment with cisplatin and HSP90 Inhibitors – towards a
              syngeneic orthotopic mouse model of pancreatic cancer therapy
              K. M. Ewers, S. Patil, W. Kopp, E. Hessmann, M. Dobbelstein (Göttingen)

P 25          Investigating the role of SMAD7 in PDAC
              I. L. Zawallich, Y. Sunami, C. Michalski, J. Kleeff (Halle a. d. Saale)

P 49          Boolean network-based modeling of gene regulatory networks mediating
              the growth-promoting role of CFL1 in pancreatic cancer
              S. Kühlwein (Ulm), T. Gress (Marburg), H. A. Kestler, M. Buchholz (Ulm)

P 50          sgRNA-transgenic mice enable inducible intra-pancreatic genome editing
              and the generation of large homozygous chromosomal deletions in vivo
              A. Mishra, K. wolff, Z. Erlangga, M. Manns, A. Vogel, A. Saborowski
              M. Saborowski (Hannover)

12:30–14:00   Poster session 5 I Surgery
Room          Terminal 2
Chairs        F. Rückert (Mannheim), S. Chikhladze (Freiburg)

P 51          Perioperative detection of deeply located pancreatic tumour lesions in mice
              using optoacoustic and fluorescence-based imaging
              J. Napp (Göttingen), M. A. Stammes (Enschede, Leiden/NL)
              J. Claussen (Munich), H. A. J. M. Prevoo, C. F. M. Sier (Gouda/NL)
              F. J. M. Hoeben (Eindhoven/NL), M. S. Robillard (Nijmegen/NL)
              A. L. Vahrmeijer (Leiden/NL), T. Devling (Munich)
              A. B. Chan (Enschede/NL), L.-F. de Geus-Oei (Leiden, Enschede/NL)
              F. Alves (Göttingen)

P 52          Accuracy of CA19-9 in detecting recurrence of pancreatic cancer after
              curative intended therapy
              A. Azizian, F. Rühlmann, T. Krause, M. Bernhardt, P. Jo, A. König (Göttingen)
              M. Kleiß (Kassel), X. Schulz, M. Ghadimi, J. Gaedcke (Göttingen)

P 53          Ultrasound imaging – method of choice in early detection of pancreatic
              carcinoma
              M. Lang, C. Tjaden, T. Hackert (Heidelberg)

                                                                                             23
POSTERSPRÄSENTATIONEN I FREITAG, 8. FEBRUAR
POSTER SESSIONS I FRIDAY, 8. FEBRUARY

P 54        Randomised controlled trial of pylorus-preserving versus pylorus-resecting
            pancreatoduodenectomy (PROPP study) – long-term morbidity and quality
            of life
            U. Klaiber, P. Probst, F. J. Hüttner, O. Strobel, M. K. Diener, A. L. Mihaljevic
            M. W. Büchler, T. Hackert (Heidelberg)

P 55        Evaluation of postoperative quality of life after pancreatic surgery and its
            influencing factors
            S. Manschikow, S. Deichmann, U. Wellner, K. C. Honselmann, L. Bolm
            L. Frohneberg, T. Keck, D. Bausch (Lübeck)

P 56        Damage control at abdominal trauma – pancreatic injuries
            M. Putzbach, S. Fabig, N. Weigert, J. Kleeff (Halle a. d. Saale)

P 57        Vein resection during pancreatectomy for pancreatic cancer:
            a meta-analysis
            Xia. Wang, I. E. Demir, S. Schorn, H. Friess, G. O. Ceyhan (Munich)

P 58        Bacterobilia does not influence delayed gastric emptying following
            pancreatoduodenectomy
            J. Hafke, S. Manekeller, J. C. Kalff, T. R. Glowka (Bonn)

P 59        Incidence and management of surgical revision requiring pancreatic fistulas
            grade C after pancreaticoduodenectomy – a retrospective analysis of 722
            patients
            A. M. Luu, T. Herzog, L. Krasemann, W. Uhl, C. Braumann (Bochum)

P 60        Effects of standardised plant extracts of the japanese Kampo medicine on
            human and murine pancreatic cancer cells
            K. Weimer, L. Frank (Göttingen), H. Rausch (Neu-Ulm), V. Ellenrieder
            S. Cameron (Göttingen)

P 61        Incidence and treatment of portal vein thromboses after portal vein
            resections in pancreatic surgery
            M. Weniger (Munich), Z. Lu (Nanjing/CN), A. Doll (Munich)
            Y. Miao (Nanjing/CN), J. Werner, J. G. D’Haese (Munich)

P 62        Expression of EWS/FLI-1 oncogene in pancreatic acinar cells induces
            adipo-cyte replacement
            Y. Sunami (Halle a. d. Saale), I. Regel, B. Kong, S. Raulefs (Munich)
            C. Michalski, J. Kleeff (Halle a. d. Saale)

24
POSTERSPRÄSENTATIONEN I FREITAG, 8. FEBRUAR
                                             POSTER SESSIONS I FRIDAY, 8. FEBRUARY

12:30–14:00   Poster session 6 I Tumor microenvironment
Terminal 3
Chairs        D. Ruess (Freiburg), K. C. Honselmann (Lübeck)

P 63          Tumor-subtype dependent transcriptional regulation in pancreatic cancer
              plasticity and resistance
              M. Tu, S. Önder, J. M. Güntner, V. Ellenrieder, S. K. Singh (Göttingen)

P 64          Exploiting tumor-stroma hedgehog signal transduction heterogeneity
              R. Singh (Marburg)

P 65          Anterior gradient 2 promotes the phenotypic transition from ADM to PanIN
              by suppressing p53 function
              Z. Zhang, L. Chang, S. Raulefs, N. Maeritz, Ya. Zhao, G. O. Ceyhan
              H. Friess (Munich), C. Michalski, J. Kleeff (Halle a. d. Saale)
              B. Kong (Munich)

P 66          NFkB2 Signaling is modulated by oncogenic context in the Carcinogenesis in
              the Pancreas
              Z. Hassan, C. Schneeweis, M. Wirth, S. Müller, R. Rad, D. Saur, R. Schmid
              G. Schneider (Munich)

P 67          Dexamethasone mediates pancreatic cancer progression by glucocorticoid
              receptor, TGFb and JNK/AP-1
              L. Liu, E. Aleksandrowicz, F. Schönsiegel, N. Bauer, C. C. Nwaeburu, Z. Zhao
              J. Gladkich, W. Groß, T. Hoppe-Tichy, O. Strobel, I. Herr (Heidelberg)

P 68          Comprehensive molecular characterisation of a pancreatic cancer PDX
              cohort for subtype-specific therapy approaches
              S.-T. Liffers, S. S. Lueong, S. Mergener, J. Forster (Essen)H. Wolters (Dortmund)
              R. Viebahn, A. Tannapfel, W. Uhl, S. Hahn (Bochum), J. Siveke (Essen)

P 69          Functional characterisation of the Ubiquitin-Proteasome-System in
              pancreatic ductal adenocarcinoma
              F. Lang, S. S. Lueong (Essen), O. Karpiuk, F. Bassermann (Munich)
              J. Siveke (Essen)

P 70          STAT3 signaling determines the oncogenic function of NFATc1 in pancreatic
              cancer plasticity and resistance
              L. Klein, S. Önder, V. Ellenrieder, S. K. Singh (Göttingen)

                                                                                           25
POSTERSPRÄSENTATIONEN I FREITAG, 8. FEBRUAR
POSTER SESSIONS I FRIDAY, 8. FEBRUARY

P 71        uPAR knock out induces mesenchymal-epithelial transition (MET) and
            chemoresistance in AsPC1 cells
            L. Peng, S. Küffer, V. Venkataramani, J. Kitz, M.-S. Bösherz
            H. Bohnenberger, F. Fuchs, S. Hakroush, P. Ströbel (Göttingen)

P 72        DeltaNp63-dependent super enhancers define molecular identity in
            pancreatic cancer by an interconnected transcription factor network
            F. Hamdan, S. A. Johnsen (Göttingen)

P 73        Growth inhibitory effects of inhibition of PLAC8 expression in exocrine
            (PDAC) and neuroendocrine (panNET) tumors of the pancreas is associated
            with deregulation of a miR-26a-E2F2 axis
            M. Stark, M. Tatura, A. Kuhl, T. Gress, M. Buchholz (Marburg)

P 74        Selective inhibition of sphingolipids metabolism in macrophages using acid
            sphingomyelinase inhibitor-coupled IL4 receptor specific aptamers
            Qi. Li, J. Peterhansl, I. Regel, U. M. Mahajan, J. Mayerle (Munich)

P 75        Oncogenic NFATc1-activity promotes cancer cachexia in murine
            PDAC-models
            D. Spyropoulou, E. Hessmann, H. Bohnenberger, D. Saul (Göttingen)

26
Abend- und Rahmenprogramm

                                                      Begrüßungsabend im Deutschen Theaterkeller
                                                      Donnerstag, 7. Februar

                                                      Mitten im Herzen Göttingens, direkt am Wall, liegt
                                                      eines der wohl beliebtesten Fotomotive der Stadt:
                                                      das Deutsche Theater Göttingen.

                                                      Wir laden Sie recht herzlich zum Begrüßungs-
                                                      abend in das Bistro ein und freuen uns, mit Ihnen
                                                      gemeinsam einen gemütlichen Abend bei kleinen
                                                      Snacks und Getränken zu verbringen.
BildPix.de l Fotolia.com

Adresse                Deutsches Theater Keller + Bistro
                       Theaterplatz 11
Beginn                 19:30 Uhr
Kosten                 kostenfrei, eine Anmeldung ist jedoch erforderlich, da die Plätze begrenzt sind

Wegbeschreibung
Das Deutsches Theater in Göttingen liegt nur 6 Gehminuten von der Alten Mensa Göttingen
entfernt.
Gehen Sie auf dem Wilhelmsplatz nach Osten und biegen Sie links auf der Burgstraße ab. Nach
ca. 100 Metern biegen Sie linkerhand auf die Theaterstraße ab und nach weiteren 200 Metern
biegen Sie links ab auf den Theaterplatz, wo Sie das Ziel erreicht haben.

Gesellschaftsabend in der Orangerie im Freizeit In Hotel
Freitag, 8. Februar

Lassen Sie die bisherigen Kongresserlebnisse Revue passieren. Zum Ausklang des zweiten
Tages laden wir Sie herzlich in die Orangerie des Hotels Freizeit In ein.

Genießen Sie einen unterhaltsamen Abend mit gutem Essen, Musik der Band „Ladies Live“
und Tanz sowie interessanten Gesprächen mit Freunden und Kollegen.

Adresse                Hotel Freizeit In GmbH
                       Dransfelder Straße 3
Beginn                 20:00 Uhr
Kosten                 45 EUR, eine Anmeldung ist erforderlich, da die Plätze begrenzt sind

Wegbeschreibung
Nur drei Gehminuten von der Alten Mensa Göttingen entfernt nutzen Sie die Buslinie 61
(Haltestelle „Jüdenstraße“) in Richtung Dransfeld zur Haltestelle „Dransfelder Straße“. Diese
liegt dem Hotel Freizeit In direkt gegenüber.

                                                                                                     27
INDUSTRIEGESTÜTZE SESSIONS

10:15–12:00   Session 4 I Satellite Symposium supported by Celgene
              Clinical trials and novel therapies
Room          Adam-von-Trott-Saal
Chairs        V. Ellenrieder (Göttingen), C. Bruns (Cologne)

10:15         Keynote I Immuno-Oncology – the basics and future perspectives
              H. Flach (Munich)

10:45         In-depth molecular characterisation of pancreatic ductal adenocarcinoma
              based on patient-derived tumor organoids
              S. Le Blanc, T. Bauer (Heidelberg), N. Ishaque (Berlin), S. Schuth, A.-K. König
              M. Volkmar, C.-S. Leonhardt, J. Jabs, U. Toprak, M. Schenk, N. Giese
              R. Offringa, C. Conrad, M. W. Büchler, M. Schlesner (Heidelberg)
              R. Eils (Heidelberg, Berlin), O. Strobel (Heidelberg)

10:53         Keynote I Future clinical trial concepts in PDAC
              J. Siveke (Essen)

11:23         Reliability of determining the resectability of locally progressed pancreatic
              ductaladenocarcinomas – results from the CONKO-007 multicenter
              randomised controlled trial (EudraCT:2009-014476-21)
              U. Wittel (Freiburg), H. Golcher, R. Grützmann (Erlangen)
              W. Bechstein (Frankfurt), O. Belyaev, W. Uhl (Bochum)
              M. Ghadimi (Göttingen), U. Hopt (Freiburg), A. Pirkl, D. Lubgan
              W. Hohenberger (Erlangen), H. Oettle (Friedrichshafen)
              R. Fietkau (Erlangen)

11:31         Comparative characterisation and epigenetic/metabolic targeting of
              primary 2D and 3D cultured PDAC cells
              S.-T. Liffers, S. Mergener, A. Winkelkotte, M. Trajkovic-Arsic, S. S. Lueong
              J. Forster (Essen), S. Hahn (Bochum), J. Siveke (Essen)

11:39         Keynote I PASS1/2 trial
              J. Neoptolemos (Heidelberg)

28
29
                                      o to lia.c o m
                  i nte r may a l f
       s p l ay
© di
INDUSTRIEGESTÜTZE SESSIONS

17:15–18:30   Session 7 I Satellite Symposium supported by Akcea
              Acute and chronic pancreatitis
Room          Adam-von-Trott-Saal
Chairs        J. Rosendahl (Halle a. d. Saale), J. Mayerle (Munich)

17:15         Myeloid derived suppressor cell (MDSCs) differentiation during acute
              pancreatitis regulates the systemic immune response
              A. Wilden, J. Glaubitz, J. Golchert, G. Homuth, F. U. Weiß (Greifswald)
              J. Mayerle (Munich), M. Sendler, M. M. Lerch (Greifswald)

17:23         Mast cell stabilisers ameliorate pain in experimental chronic pancreatitis
              S. Klauss, S. Schorn, S. Teller, H. Friess, G. O. Ceyhan, I. E. Demir (Munich)

17:31         Keynote I Pancreatitis in patients with lipid disorders
              M. M. Lerch (Greifswald)

18:01         Gender-dependent mechanisms of autophagy in the transition of acute to
              chronic pancreatitis
              K. Diakopoulos, A. Berninger, M. Kowalska, K. Görgülü, M. Lesina, J. Ai
              A.-F. Karpathaki, D. Kabacaoglu, K. J. Ciecielski, E. Kaya-Aksoy, R. Schmid
              H. Algül (Munich)

18:09         Pancreatic autophagy attenuates endotoxin-induced pancreatic injury
              L. Xia, T. Hackert, F. Fortunato (Heidelberg)

18:17         Absence of LMP7 immunoproteasome subunit leads to delayed organ
              recovery after acute pancreatitis
              L. De Freitas Chama, F. U. Weiß, F. Ebstein, E. Krüger, M. M. Lerch
              M. Sendler (Greifswald)

30
Connecting and Advancing
                     Health Sciences

The Interdisciplinary Approach to
Gastrointestinal Medicine
VISCERAL MEDICINE is your one-stop source for essential knowledge                                                  Visceral

                                                                                                   Breast Care
needed to master the major interdisciplinary challenges in gastro-                                                  Medicine
intestinal medicine and surgery. Each issue focuses on one selec-
                                                                                                                                            Gastroenterology, Endoscopy and Surgery –
                                                                                                                                            The Interdisciplinary Approach to Gastrointestinal Disease

ted topic, and the invited reviews provide a comprehensive, state-
of-the-art background in clinical practice and research. A panel of
specialists in gastroenterology, surgery, radiology, and pathology
discusses different approaches to diagnosis and treatment of the
featured topic. Original articles, case reports, and commentaries                                                  S. Karger
                                                                                                                   Medical and Scientific Publishers
                                                                                                                   Basel · Freiburg · Paris · London ·                      Associated Organ
                                                                                                                   New York · Chennai · New Delhi ·                 for Continuing Education

add additional valuable insights.
                                                                                                                   Bangkok · Beijing · Shanghai ·
                                                                                                                   Tokyo · Kuala Lumpur ·
                                                                                                                   Singapore · Sydney

                                                                                                                 www.karger.com/vis
           In cooperation with DGAV
           (Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie)

More than 40 Years of Excellence
For over 40 years, ONCOLOGY RESEARCH AND TREATMENT has been an inter-
disciplinary forum for cancer research and treatment. Peer-reviewed
original and review articles cover a wide range of topics and aspects
in medical and hemato-oncology. Focus issues select one specific
cutting-edge topic and expand on its various facets in the form of
mini reviews. Compact and current, ONCOLOGY RESEARCH AND TREATMENT
keeps both clinicians and researchers up-to-date.
                                                                                                                                                                                               Österreichische Gesellschaft für
                                                                                                                                                                                               Hämatologie & Medizinische Onkologie

                   Österreichische Gesellschaft für
                   Hämatologie & Medizinische Onkologie
                                                                                                                 www.karger.com/ort
Official        DGHO – Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
Organ of        ÖGHO – Österreichische Gesellschaft für Hämatologie und Medizinische Onkologie
                DFaG – Deutsche Fatigue Gesellschaft
                AIO – Arbeitsgemeinschaft Internistische Onkologie in der deutschen Krebsgesellschaft e.V.
                SGH-SSH – Schweizerische Gesellschaft für Hämatologie
Member of       Deutsche Krebsgesellschaft e.V.

S. Karger Verlag für Medizin und Naturwissenschaften GmbH
Wilhelmstraße 20A                                         t +49 761 45207- 0
79098 Freiburg                                            f +49 761 45207- 14
www.karger.com                                            information@karger.com
                                                                                                                                                                                                                                      31
SPONSOREN UND MEDIENKOOPERATION

Ein großes Dankeschön gilt allen Partnern für ihre Unterstützung und kooperative Zusammenarbeit:

Premiumsponsoren
Akcea Therapeutics

Celgene GmbH

Silbersponsoren
SERVIER Deutschland GmbH

Bronzesponsoren
Bristol-Myers Squibb GmbH & Co. KGaA

GE Healthcare GmbH

Johnson & Johnson Medical GmbH - Ethicon

Ipsen Pharma GmbH

Weitere Sponsoren
Boston Scientific

Halozyme, Inc.

Lilly Deutschland GmbH

MTW-Endoskopie W. Haag KG


Peter Pflugbeil GmbH

Medienkooperation
S. Karger GmbH
„Karger Kompass Onkologie“
„Oncology Research and Treatment“
„Visceral Medicine“                                                         Stand bei Drucklegung

32
Successful patient management
                          requires a lot more than one move.

                                                                                                                AXIOS™
                                                                       Stent and Electrocautery Enhanced Delivery System

                                                            Bringing the patient care pieces together.

                                                           The AXIOS Stent and Delivery System is indicated for use to facilitate
                                                   transgastric or transduodenal endoscopic drainage of a pancreatic pseudocyst
                                                             or a walled-off necrosis with ≥ 70% fluid content or the biliary tract.

                                                                                                     All trademarks are the property of their respective owners.
                                                                                 Caution: The law restricts this device to sale by or on the order of a physician.
                                                                          Product available in the European Economic Area (EEA) only. Please check availability
                                                                                                       with your local sales representative or customer service.
                                                                          Indications, Contraindications, Warnings and Instructions for Use can be found in the
                                                                                                                    product labeling supplied with each device.
Contact your local sales representative or visit                                                                                                      33
                                                                            2016 Copyright © Boston Scientific Corporation or its affiliates. All rights reserved.
www.bostonscientifi c.eu/gastroenterology.                                                                                                     ENDO-426401-AA
AUSSTELLER

Aussteller                                     Standnummer

Arbeitskreis der Pankreatektomierten e. V.                    9

Akcea Therapeutics                                            5

BAXTER Deutschland GmbH                                      12

Bracco Imaging Deutschland GmbH                              18

Bristol-Myers Squibb                                         16

Celgene GmbH                                                  7

Dr. Falk Pharma GmbH                                          2

Ewimed                                                       11

GE Healthcare GmbH                                            8

IntraOp                                                      14

Ipsen Pharma GmbH                                             4

Johnson & Johnson                                            19

Liquid Biopsy GmbH                                           21

LISA Laser Products GmbH                                      1

Meda Pharma                                                  20

Medi-Globe GmbH                                              10

Medtronic                                                    15

Nordmark Arzneimittel GmbH & Co. KG                           6

Novartis Pharma GmbH                                         13

Roche Pharma AG                                              17

Servier Deutschland GmbH                                      3

                                             Stand bei Drucklegung

34
RAUM- UND AUSSTELLERPLAN

                         16      3

          1
                         5    11 15      21
                  2
                              10 14
                                         20
         2                    9 13
                                         19
                               8 12
                         4               18
                                 7
                                         17
                         3

            zum
        Vortragssaal
                                 6
                       g
                    an
                  ng
                   i
                te
              up
             Ha

                              ePoster Sta on

    1                         Catering

                              Check-In
                                                Stand bei Drucklegung

                                                                  35
ALLGEMEINE INFORMATIONEN

           Allgemeine Geschäftsbedingungen
           Die Allgemeinen Geschäftsbedingungen entnehmen Sie bitte der Tagungs-
     AGB
           homepage.

           Anwesenheitslisten und Teilnahmezertifikate
           Für die Zertifizierung werden die Teilnehmer gebeten, sich täglich mit ihrem
           EFN-Barcode am Check-In einzuscannen. Dort erhalten Sie auch die Teilneh-
           merzertifikate.

           Catering
           Getränke und Snacks werden den Teilnehmern kostenfrei während der
           Pausen angeboten.

           Kongresssprache
           Die Vorträge sowie Posterpräsentationen werden auf Englisch gehalten.

           Posterausstellung
           Alle Poster können während der gesamten Tagung sowohl an den ePoster-
           Terminals als auch an kleinen Bildschirmen zum Selbststudium eingesehen
           werden.

           Vortragsannahme
           Bitte geben Sie Ihren Vortrag direkt im Hörsaal ab.

           Wissenschaftliche Preise
           Die Preisverleihungen finden während des Gesellschaftsabends am Freitag
           statt. Die besten Abstracteinreichungen sind im Programm mit einem Pokal
           gekennzeichnet.

           Zertifizierung und Fortbildungspunkte
           Die 39. Jahrestagung des Deutschen Pankreasclub e. V. wurde von der Ärzte-
           kammer Niedersachsen mit folgenden Punkten zertifiziert:
           Donnerstag          3 Punkte
           Freitag 		          6 Punkte
           Samstag 		          3 Punkte

36
Index Referenten, Autoren und Vorsitzende

A
Abdelhafez, M.                           12   Berninger, A.                             13, 30
Acciuffi, S.                           7, 9   Bertucci, F.                                  12
Ai, J.                               13, 30   Beyer, G.                                     20
Aichler, M.                              22   Biesel, E. A.                                 19
Akkan, J.                             8, 16   Birgin, E.                                    17
Aleksandrowicz, E.                       25   Birnbaum, Dan.                                12
Algül, H.             7, 13, 20, 21, 22, 30   Birnbaum, Dav.                                12
Alhamdani, M. S. S.                      15   Böhme, C.                                     20
Alnabki, M.                              19   Böhme, R.                                     20
Alves, F.                            22, 23   Bohnenberger, H.                      16, 19, 26
Aperdannier, L.                      16, 18   Böker, V.                                     15
Appel, L.                                15   Bolm, L.                           9, 11, 18, 24
Arlt, A.                          6, 11, 21   Bolsmann, R.                                  20
Arnold, F.                                7   Bösherz, M.-S.                                26
Aselmann, H.                             11   Bosio, A.                                     22
Augustin, L.                             12   Bourquain, U.                                 17
Azizian, A.                              23   Braren, R.                                12, 20
                                               Braumann, C.                              18, 24
B                                              Breitling, L. P.                              14
Babatz, J.                              21    Breunig, M.                                8, 16
Bahra, M.                               11    Bronsert, P.                                  14
Bassermann, F.                          25    Brooks, J.                                     9
Bauer, A. S.                            15    Brückner, S.                              11, 21
Bauer, C.                               17    Bruns, C.                             10, 12, 28
Bauer, N.                               25    Buchholz, M.                      17, 18, 23, 26
Bauer, T.                           10, 28    Buchler, M.                                    9
Baum, R. P.                             14    Büchler, M. W.          7, 9, 10, 15, 19, 24, 28
Baumann, D.                             12    Büchter, M.                                    8
Bausch, D.               9, 11, 16, 18, 24    Busch, C.                                     11
Bazhin, A. V.                    7, 17, 20
Bechstein, W.                       10, 28    C
Becker, T.                              11    Cameron, S.                                   24
Begg, S.                                12    Cao, J.                                    8, 16
Belyaev, O.                     10, 18, 28    Ceyhan, G. O.       8, 9, 12, 13, 15, 16, 17, 24
Benitz, S.                       8, 16, 22                                             25, 30
Bergmann, F.                            14    Chan, A. B.                                   23
Bernhardt, M.                           23    Chang, L.                                16, 25
Berning, M.                             21    Cheung, P. F.-Y.                              23

                                                                                            37
Index Referenten, Autoren und Vorsitzende

Chikhladze, S.                             23    Ellenrieder, V. 8, 10, 12, 15, 19, 24, 25, 28
Ciecielski, K. J.                     13, 30     Ellrichmann, M.                        11, 21
Claussen, J.                               23    Engleitner, T.                             12
Conrad, C.                         10, 17, 28    Erlangga, Z.                               23
Croner, R.                           7, 9, 21    Esposito, I.                           16, 22
                                                  Ewers, K. M.                               23
D
D’Haese, J. G.                   7, 16, 20, 24   F
Dahlhoff, M.                            20, 22   Faber-Zuschratter, H.                        21
Dantes, Z.                                  12   Fabig, S.                                    24
De Freitas Chama, L.                    13, 30   Fahlbusch, T.                                18
de Geus-Oei, L.-F.                          23   Fahr, L.                                  8, 22
De La Torre, C.                             22   Feldmann, K.                                 12
Deichmann, S.                           11, 24   Felix, K.                                    14
Demir, I. E.          7, 9, 13, 15, 17, 24, 30   Fernandez-del Castillo, C.                   12
Devling, T.                                 23   Fichtner-Feigl, S.                           19
D‘Haese, J. G.        7, 8, 16, 17, 18, 20, 24   Fietkau, R.                              10, 28
Diakopoulos, K.                     13, 21, 30   Finetti, P.                                  12
Diamandis, E. P.                            18   Flach, H.                                10, 28
Diener, M. K.                               24   Flossdorf, M.                                15
Dimopoulus, I.                              19   Forster, J.                          10, 25, 28
Dinh, B. B. K.                              16   Fortunato, F.                            13, 30
Distler, M.                              9, 11   Frank, L.                                    24
Dobbelstein, M.                             23   Frappart, P.-O.                           7, 16
Doll, A.                                    24   Friess, H. 8, 9, 12, 13, 15, 16, 17, 24, 25, 30
Dralle, H.                                   9   Frohneberg, L.                           11, 24
Drebant, J.                                 12   Fuchs, F.                                    26
Drewes, R.                                   7   Füldner, F.                                  11
Drexler, R.                                 18
Dudeck, O.                                  19   G
                                                  Gaedcke, J.                       6, 9, 18, 23
E                                                 Gartung, C.                                 19
Eberhard, J.                               18    Gastinger, I.                                9
Ebstein, F.                            13, 30    Georgikou, C.                               22
Eils, R.                               10, 28    Gerdes, B.                                  19
Eiseler, T.                                12    Gerken, G.                                   8
Elhabash, S.                               19    Ghadimi, M.                 10, 12, 18, 23, 28
El-Hage, F.                                20    Ghaneh, P.                                   9

38
Sie können auch lesen
NÄCHSTE FOLIEN ... Stornieren