Prof. Martin Brutsche - Kontakt Titel Vorname Nachname Strasse Stadt Land Telefonnummer - Research KSSG
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Prof. Martin Brutsche Kontakt Titel Prof Vorname Martin Nachname Brutsche Strasse Rorschacher Strasse 95 Stadt 9007 St. Gallen Land Switzerland Telefonnummer 0041 71 494 1004 E-Mail martin.brutsche@kssg.ch Webseite http://www.pneumologie.kssg.ch
Forschungsprofil
Akademischer Status Chefarzt/Chefärztin
Departement I
Abteilung Pneumologie/Schlafmedizin
Position Chefarzt Pneumologie und interdisziplinäres
Schlafzentrum
2Forschungsprofil
Frühere Positionen Oktober 1990 - Dezember 1991:
Wissenschaftlicher Mitarbeiter, SNF Projekt 26A
("Swiss Study on Air Pollution and Lung Disease in
Adults", SAPALDIA, Multizenterstudie)
Pneumologiezentrum Montana/VS, Prof. Dr. P.
Leuenberger, PD Dr. J.M. Tschopp und SAPALDIA
Studienteam
Januar 1992 - Dezember 1993:
Assistenzarzt Innere Medizin, Regionalspital Sta.
Maria, Visp/VS, Dr. A. Nanzer, Dr. J.L. Troillet, Dr. L.
Roten
Januar 1994 - Dezember 1995:
Oberarzt am Pneumologiezentrum Montana/VS,
Pneumologie, PD Dr. J.-M. Tschopp
Januar 1996 - September 1997:
Oberassistenzarzt Innere Medizin, Universitätsspital
Genf/GE, Innere Medizin, Notaufnahme,
Intensivstation, Pneumologie, Onkologie, Prof. Dr.
A. Junod
September 1997 - September 1999:
Wissenschaftlicher Oberarzt, North West Lung
Centre, South Manchester University Hospital
Wythenshawe, Manchester, UK, Pnuemologie,
Forschung im Gebiet Pneumologie, Prof. A.
Woodcock
Gleichzeitig PhD Kurs in der Fakultät für Biologische
Wissenschaften ("Gene Expression in Atopy and
3Forschungsprofil
Asthma", Prof. A. Woodcock, Dr. P. Wood)
Promotion: August 2000
Oktober 1999 - April 2009:
Stellvertretender Leiter des Fachbereichs
Pneumologie, Innere Medizin, Universitätsspital
Basel, Prof. M. Tamm und Forschungsgruppenleiter
Pulmonary Gene Research Group
Januar - Dezember 2006:
Leiter Pneumologie während des Forschungsurlaubs
von Prof. M. Tamm
Juni 2006 - April 2008:
Leiter des Lungenzentrums Basel, ein
interdisziplinäres Zentrum, welches 7 Fachbereiche
zur Behandlung maligner Thoraxerkrakungen und
interstitieller Lungererkrankungen einschliesst
Mai 2008 - März 2009:
Chefarzt und Klinikleiter Pneumologie,
Kantonsspital Aarau
Seit April 2009:
Chefarzt Pneumologie und Interdisziplinäres
Schlafzentrum, Kantonsspital St. Gallen
4Forschungsprofil
Mitgliedschaften Verbindung der Schweizer Aerzte FMH
Schweizerische Gesellschaft für Pneumologie
Schweizerische Gesellschaft für Innere Medizin
Schweizerische Gesellschaft für Schlafmedizin
Medizinische Gesellschaft Aargau
European Respiratory Society
Britisch Thoracic Society
Americal Thoracic Society
American College of Chest Physicians, Fellow FCCP
5Forschungsprofil
Auszeichnungen Erster Preis: "Preis für Medizin 1992/1993" in der
Schweizerischen Rundschau für Medizin PRAXIS,
Juli 1993, Bern: Brutsche M, Frey JG, Tschopp JM.
Lutte contre le tabac et médecin praticien. Schweiz
Rundschau Med (Praxis) 1993; 44:1234-38
"Global Young Investigator Award 2002" Ely Lilly,
Indianapolis, USA, für das Projekt "Genomic
predictors of response to gemictabine monotherapy
as palliative chemotherapy in peripheral blood and
tumour tissue samples of patients with NSCLC".
Hauptprüfarzt: Brutsche MH
Schweizerische Gesellschaft für Pneumologie,
Posterpreis 2003 für das Projekt "Early growth
response genes are preferentially transactivated in
stage II/III sarcoidosis" Brutsche MH, Laule-Kilian
K, Eryüsel E, Rutherford R, Bihl M, Joos L, Kehren J,
Staedtler F, Tamm M, Bubendorf L.
Schweizerische Gesellschaft für Pneumologie,
Posterpreis 2004 für das Projekt "Prediction of
treatment-response to inhaled corticosteroids by
mannitol-challenge test in COPD" Tandjung R,
Anderson SD, Brutsche MH, Bingisser R, Perruchoud
AP, Surber C, Tamm M, Leuppi JD
"Young Investigators Award of the International
Association for the Study of Lung Cancer" für das
Abstract: "Prediction of major NSCLC tumor classes
and clinical outcome by functional genomics of
small bronchoscopic tumor biopsies" F. Baty, M.
6Forschungsprofil
Buess, S. Kaiser, M. Facompré, L. Bubendor, M.
Schumacher, W. Budach, J. Kehren und M. Brutsche
Preis für die beste Präsentation am Treffen der
Schweizerischen Gesellschaft für Pneumologie 2008
in Fribourg für das Projekt: "Prevalence and
geographic distribution of sarcoidosis in
Switzerland" by Deubelbeiss U, Gemperli A,
Schindler C, Baty F, Brutsche MH
Patente Baty F, Brutsche M. Composite Dimensional
Analysis (CDA): Exploration of individualized
disease dimensions using functional genomics. US-
patent WTT05/086KBS
Brutsche M, Baty F, Schumacher M, Kehren J. Gene
Expression signatures for lung cancer. GB-patent
P051025GB
7Publikationen
Titel
Wissensch- Maeder M T, Weber L, Weilenmann D, Chronis J, Jörg L, Pohle S, Haager P
aftlicher K, Brutsche M, Neumann T, Schoch O, Rickli H. Impact of the new
Artikel/ pulmonary hypertension definition on long-term mortality in patients with
Review severe aortic stenosis undergoing valve replacement. Clin Cardiol 2021;.
Bösch M, Baty F, Rothschild S I, Tamm M, Joerger M, Früh M, Brutsche M.
Tumour neoantigen mimicry by microbial species in cancer
immunotherapy. Br J Cancer 2021;.
Bösch M, Sykora M, Gasteiger S, Baty F, Brutsche M, Sopper S. OMIP
077: Definition of all principal human leukocyte populations using a
broadly applicable 14-color panel. Cytometry A 2021;.
Bösch M, Baty F, Brutsche M, Tamm M, Roux J, Knudsen L, Gazdhar A,
Geiser T, Khan P, Hostettler K E. Transcriptomic profiling reveals disease-
specific characteristics of epithelial cells in idiopathic pulmonary fibrosis.
Respir Res 2020; 21:165.
Baty F, Bösch M, widmer s, Annaheim S, Fontana P, Camenzind M, Rossi
R M, Schoch O, Brutsche M. Classification of Sleep Apnea Severity by
Electrocardiogram Monitoring Using a Novel Wearable Device. Sensors
(Basel) 2020; 20:.
Tonko S, Baty F, Brutsche M, Schoch O. Length of hospital stay for TB
varies with comorbidity and hospital location. Int J Tuberc Lung Dis 2020;
24:948-955.
Sievi N A, Brack T, Brutsche M, Frey M, Irani S, Leuppi J D, Thurnheer R,
Kohler M, Clarenbach C F. "Can do, don't do" are not the lazy ones: a
longitudinal study on physical functioning in patients with COPD. Respir
Res 2020; 21:27.
8Publikationen
Titel
Wissensch- Sanchez J, Schumann D M, Karakioulaki M, Papakonstantinou E, Rassouli
aftlicher F, Frasnelli M, Brutsche M, Tamm M, Stolz D. Laryngopharyngeal reflux in
Artikel/ chronic obstructive pulmonary disease - a multi-centre study. Respir Res
Review 2020; 21:220.
Tinschert P, Rassouli F, Barata F, Steurer-Stey C, Fleisch E, Puhan M A,
Kowatsch T, Brutsche M. Nocturnal Cough and Sleep Quality to Assess
Asthma Control and Predict Attacks. J Asthma Allergy 2020; 13:669-678.
Rassouli F, Tinschert P, Barata F, Steurer-Stey C, Fleisch E, Puhan M A,
Baty F, Kowatsch T, Brutsche M. Characteristics of Asthma-related
Nocturnal Cough: A Potential New Digital Biomarker. J Asthma Allergy
2020; 13:649-657.
Barata F, Tinschert P, Rassouli F, Steurer-Stey C, Fleisch E, Puhan M A,
Brutsche M, Kotz D, Kowatsch T. Automatic Recognition, Segmentation,
and Sex Assignment of Nocturnal Asthmatic Coughs and Cough Epochs in
Smartphone Audio Recordings: Observational Field Study. J Med Internet
Res 2020; 22:e18082.
Tinschert P, Rassouli F, Barata F, Steurer-Stey C, Fleisch E, Puhan M A,
Brutsche M, Kowatsch T. Prevalence of nocturnal cough in asthma and its
potential as a marker for asthma control (MAC) in combination with sleep
quality: protocol of a smartphone-based, multicentre, longitudinal
observational study with two stages. BMJ Open 2019; 9:e026323.
Sievi N A, Kohler M, Thurnheer R, Leuppi J D, Irani S, Frey M, Brutsche
M, Brack T, Clarenbach C F. No impact of exacerbation frequency and
severity on the physical activity decline in COPD: a long-term
observation. Int J Chron Obstruct Pulmon Dis 2019; 14:431-437.
9Publikationen
Titel
Wissensch- Schoch O, Baty F, Bösch M, Benz G, Niedermann J, Brutsche M.
aftlicher Telemedicine for Continuous Positive Airway Pressure in Sleep Apnea: A
Artikel/ Randomized, Controlled Study. Ann Am Thorac Soc 2019;.
Review Fontana P, Martins N R A, Camenzind M, Bösch M, Baty F, Schoch O,
Brutsche M, Rossi R M, Annaheim S. Applicability of a Textile ECG-Belt for
Unattended Sleep Apnoea Monitoring in a Home Setting. Sensors (Basel)
2019; 19:.
Fontana P, Martins N R A, Camenzind M, Rossi R M, Baty F, Bösch M,
Schoch O, Brutsche M, Annaheim S. Clinical Applicability of a Textile 1-
Lead ECG Device for Overnight Monitoring. Sensors (Basel) 2019; 19:.
Bösch M, Baty F, Rumpold H, Sopper S, Wolf D, Brutsche M. Fibroblasts in
cancer: Defining target structures for therapeutic intervention. Biochim
Biophys Acta Rev Cancer 2019; 1872:111-121.
Rassouli F, Boutellier D, Duss J, Huber S, Brutsche M. Digitalizing
multidisciplinary pulmonary rehabilitation in COPD with a smartphone
application: an international observational pilot study. Int J Chron
Obstruct Pulmon Dis 2018; 13:3831-3836.
Brutsche M, Rassouli F, Gallion H, Kalra S, Roger V L, Baty F. Diagnostic
diversity - an indicator of institutional and regional healthcare quality.
Swiss Med Wkly 2018; 148:w14691.
Cheng H W, Onder L, cupovic j, Bösch M, Novkovic M, Pikor N, Tarantino
I, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. CCL19-
producing fibroblastic stromal cells restrain lung carcinoma growth by
promoting local antitumor T-cell responses. J Allergy Clin Immunol 2018;.
10Publikationen
Titel
Wissensch- Hostettler K, Baty F, Kleiner R, Junker L, Tamm M, Brutsche M. Bosentan
aftlicher for patients with steroid-resistant pulmonary sarcoidosis: a randomised
Artikel/ controlled trial. Swiss Med Wkly 2018; 148:w14677.
Review Evans R, Brutsche M, Busca R, Deslee G, de Soyza A, Fellrath J M,
Franzen D, Hartman J, Mealing S, Morton T, Munavvar M, Sculpher M,
Shah P, Slebos D J, Durand-Zaleski I. Quantifying patient centered
outcomes associated with the use of bilateral endobronchial coil
treatment in patients with severe emphysema. Curr Med Res Opin 2018;
34:1927-1932.
Sievi N A, Brack T, Brutsche M, Frey M, Irani S, Leuppi J D, Thurnheer R,
Kohler M, Clarenbach C F. Physical activity declines in COPD while
exercise capacity remains stable: A longitudinal study over 5 years.
Respir Med 2018; 141:1-6.
Stolz D, Barandun J, Borer H, Bridevaux P O, Brun P, Brutsche M,
Clarenbach C, Eich C, Fiechter R, Frey M, Geiser T, Grob M, Helfenstein E,
Junker L, Kohler M, Latshang T, Lechmann A, Maurer M, Nicod L, Quadri
F, Schilter D, Sigrist T, Soccal P, Tarr P, Thurnheer R, Turk A, Tamm M.
Diagnosis, Prevention and Treatment of Stable COPD and Acute
Exacerbations of COPD: The Swiss Recommendations 2018. Respiration
2018; 96:382-398.
Clarenbach C F, Sievi N A, Haile S R, Brack T, Brutsche M, Frey M, Irani S,
Leuppi J D, Thurnheer R, Kohler M. Determinants of annual change in
physical activity in COPD. Respirology 2017; 22:1133-1139.
Baty F, Joerger M, Früh M, Klingbiel D, Zappa F, Brutsche M. 24h-gene
variation effect of combined bevacizumab/erlotinib in advanced non-
squamous non-small cell lung cancer using exon array blood profiling. J
Transl Med 2017; 15:66.
11Publikationen
Titel
Wissensch- Horvath C M, Brutsche M, Schoch O, Schillig B, Baty F, vonOw D, Rüdiger
aftlicher J J. Erratum to: NIV by an interdisciplinary respiratory care team in
Artikel/ severe respiratory failure in the emergency department limited to day
Review time hours. Intern Emerg Med 2017; 12:1339.
Salomon J, Stolz D, Domenighetti G, Frey J G, Turk A J, Azzola A, Sigrist
T, Fitting J W, Schmidt U, Geiser T, Wild C, Kostikas K, Clemens A,
Brutsche M. Indacaterol and glycopyrronium versus indacaterol on body
plethysmography measurements in COPD-a randomised controlled study.
Respir Res 2017; 18:13.
Annaheim S, Camenzind M, Schoch O, Brutsche M, Baty F, Rossi R.
Session 59. Biosignal processing and monitoring IV. Biomed Tech (Berl)
2017; 62:s526-s530.
Sievi N A, Brack T, Brutsche M, Frey M, Irani S, Leuppi J D, Thurnheer R,
Kohler M, Clarenbach C F. Accelerometer- versus questionnaire-based
assessment of physical activity and their changes over time in patients
with COPD. Int J Chron Obstruct Pulmon Dis 2017; 12:1113-1118.
Rassouli F, Schneider T, Dutly A, glasergallion f, Brutsche M.
Lungenemphysem. Schweiz Med Forum 2017; 2017/43:917-924.
Rassouli F, Baty F, Stolz D, Albrich W C, Tamm M, Widmer S, Brutsche M.
Longitudinal change of COPD assessment test (CAT) in a telehealthcare
cohort is associated with exacerbation risk. Int J Chron Obstruct Pulmon
Dis 2017; 12:3103-3109.
Feigelman R, Kahlert C R, Baty F, Rassouli F, Kleiner R L, Kohler P,
Brutsche M, von Mering C. Sputum DNA sequencing in cystic fibrosis:
non-invasive access to the lung microbiome and to pathogen details.
Microbiome 2017; 5:20.
12Publikationen
Titel
Wissensch- Baty F, Ritz C, Jensen S M, Kern L, Tamm M, Brutsche M. Multimodel
aftlicher inference applied to oxygen recovery kinetics after 6-min walk tests in
Artikel/ patients with chronic obstructive pulmonary disease. PLoS ONE 2017;
Review 12:e0187548.
Funke-Chambour M, Azzola A, Adler D, Barazzone-Argiroffo C, Benden C,
Boehler A, Bridevaux P O, Brutsche M, Clarenbach C F, Hostettler K,
Kleiner-Finger R, Nicod L P, Soccal P M, Tamm M, Geiser T, Lazor R.
Idiopathic Pulmonary Fibrosis in Switzerland: Diagnosis and Treatment.
Respiration 2017; 93:363-378.
Baty F, van Gestel A J R, Kern L, Brutsche M. Oxygen Uptake Recovery
Kinetics after the 6-Minute Walk Test in Patients with Chronic Obstructive
Pulmonary Disease. Respiration 2016; 92:371-379.
Cernomaz A T, Macovei I I, Pavel I, Grigoriu C, Marinca M, Baty F, Peter
S, Zonda R, Brutsche M, Grigoriu B D. Comparison of next generation
sequencing, SNaPshot assay and real-time polymerase chain reaction for
lung adenocarcinoma EGFR mutation assessment. BMC Pulm Med 2016;
16:88.
Horvath C M, Brutsche M, Baty F, ruediger j. Transcutaneous versus blood
carbon dioxide monitoring during acute noninvasive ventilation in the
emergency department - a retrospective analysis. Swiss Med Wkly 2016;
146:w14373.
Kleiner R, Brutsche M. [In Process Citation]. Ther Umsch 2016; 73:31-5.
Baty F, Ritz C, van Gestel A, Brutsche M, Gerhard D. Modeling the oxygen
uptake kinetics during exercise testing of patients with chronic
obstructive pulmonary diseases using nonlinear mixed models. BMC Med
Res Methodol 2016; 16:66.
13Publikationen
Titel
Wissensch- Müller J, Putora P M, Schneider T, Zeisel C, Brutsche M, Bartz-Batliner M,
aftlicher Markus A, Kick J. Handheld single photon emission computed tomography
Artikel/ (handheld SPECT) navigated video-assisted thoracoscopic surgery of
Review computer tomography-guided radioactively marked pulmonary lesions.
Interact Cardiovasc Thorac Surg 2016; 23:345-350.
Horvath C M, Brutsche M, Schoch O, Schillig B, Baty F, vonOw D, ruediger
j. NIV by an interdisciplinary respiratory care team in severe respiratory
failure in the emergency department limited to day time hours. Intern
Emerg Med 2016;.
Brutsche M. NIV by an interdisciplinary respiratory care team in severe
respiratory failure in the emergency department limited to day time
hours. Intern Emerg Med 2016;.
Rassouli F, Pfister M, Widmer S, Baty F, Burger B, Brutsche M.
Telehealthcare for Chronic Obstructive Pulmonary Disease in Switzerland
Is Feasible and Appreciated by Patients. Respiration 2016; 92:107-13.
Baty F, Joerger M, Früh M, Brutsche M. 61PD 24h-blood profile gene
expression biomarkers of the response to targeted therapy in advanced
non-squamous non-small cell lung cancer (NSCLC). J Thorac Oncol 2016;
11:S81.
Neumair P, Joos L, Warschkow R, Dutly A, Ess S, Hitz F, Früh M, Brutsche
M, Baty F, Krähenbühl S, cerny t, Joerger M. Erlotinib has comparable
clinical efficacy to chemotherapy in pretreated patients with advanced
non-small cell lung cancer (NSCLC): A propensity-adjusted, outcomes
research-based study. Lung Cancer 2016; 100:38-44.
Brutsche M. NIV by an interdisciplinary respiratory care team in severe
respiratory failure in the emergency department limited to day time
hours. Intern Emerg Med 2016;.
14Publikationen
Titel
Wissensch- Pohle S, Baty F, Brutsche M. In-Hospital Disease Burden of Sarcoidosis in
aftlicher Switzerland from 2002 to 2012. PLoS ONE 2016; 11:e0151940.
Artikel/ Baty F, Klingbiel D, Zappa F, Brutsche M. High-throughput alternative
Review splicing detection using dually constrained correspondence analysis
(DCCA). J Biomed Inform 2015;.
Sievi N A, Senn O, Brack T, Brutsche M, Frey M, Irani S, Leuppi J D,
Thurnheer R, Franzen D, Kohler M, Clarenbach C F. Impact of
comorbidities on physical activity in COPD. Respirology 2015; 20:413-8.
horvath c, Schneider T, Kluckert T, Brutsche M. [ARDS after Incidental
Aspiration of Petroleum in an Adult.]. Pneumologie 2015;.
Frasnelli M, Baty F, Niedermann J, Brutsche M, Schoch O. Effect of
telemetric monitoring in the first 30 days of continuous positive airway
pressure adaptation for obstructive sleep apnoea syndrome - a controlled
pilot study. J Telemed Telecare 2015; 22:209-14.
Hansen J, Rassouli F, Brutsche M. [Cardiopulmonary exercise testing
(CPET) – indication and clinical impact]. Ther Umsch 2015; 72:321-6.
Alexandrova E, Miglino N, Hashim A, Nassa G, Stellato C, Tamm M, Baty
F, Brutsche M, Weisz A, Borger P. Small RNA profiling reveals deregulated
phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase
(PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic
patients. J Allergy Clin Immunol 2015;.
Spahr Y, Brutsche M, Valmaggia C. [The role of chronic or transient
hypoxia on the retinal nerve fiber layers]. Klin Monbl Augenheilkd 2015;
232:395-8.
15Publikationen
Titel
Wissensch- Gautschi O, Mach N, Rothschild S I, Li Q, Stahel R A, Zippelius A,
aftlicher Cathomas R, Früh M, Betticher D C, Peters S, Rauch D, Feilchenfeldt J,
Artikel/ Bubendorf L, Savic S, Jaggi R, Leibundgut E O, Largiadèr C, Brutsche M,
Review Pilop C, Stalder L, Pless M, Ochsenbein A F, Swiss Group for Clinical
Cancer Research . Bevacizumab, Pemetrexed, and Cisplatin, or
Bevacizumab and Erlotinib for Patients With Advanced Non-Small-Cell
Lung Cancer Stratified by Epidermal Growth Factor Receptor Mutation:
Phase II Trial SAKK19/09. Clin Lung Cancer 2015; 16:358-65.
van Gestel A J R, Baty F, Rausch-Osthof A K, Brutsche M.
Cardiopulmonary and gas-exchange responses during the six-minute
walk test in patients with chronic obstructive pulmonary disease.
Respiration 2014; 88:307-14.
Kern L, Condrau S, Baty F, Wiegand J, van Gestel A J, Azzola A, Tamm M,
Brutsche M. Oxygen kinetics during 6-minute walk tests in patients with
cardiovascular and pulmonary disease. BMC Pulm Med 2014; 14:167.
horvath c, albrich w, Kluckert J T, Brutsche M. Eine gefährliche
Kombination : Nekrotisierende Pneumonie mit ambulant erworbenem
Panton-Valentine Leukozidin-bildendem Methicillin-resistentem
Staphylococcus aureus nach Influenza. Schweizerisches Medizin Forum
2014;728-730.
Dusemund F, Chronis J, Baty F, Albrich W C, Brutsche M. The outcome of
community-acquired pneumonia in patients with chronic lung disease: a
case-control study. Swiss Med Wkly 2014; 144:w14013.
16Publikationen
Titel
Wissensch- Zurek M, Maeder M T, Brutsche M, Lüthi A, Twerenbold R, Freese M, Rickli
aftlicher H, Mueller C. Midregional pro-adrenomedullin and copeptin: exercise
Artikel/ kinetics and association with the cardiopulmonary exercise response in
Review comparison to B-type natriuretic peptide. Eur J Appl Physiol 2014;
114:815-24.
Joerger M, Baty F, Früh M, Droege C, Stahel R A, Betticher D C, von Moos
R, Ochsenbein A, Pless M, Gautschi O, Rothschild S, Brauchli P, Klingbiel
D, Zappa F, Brutsche M. Circulating microRNA profiling in patients with
advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed
by platinum-based chemotherapy at progression (SAKK 19/05). Lung
Cancer 2014; 85:306-13.
Nowak C, Sievi N A, Clarenbach C F, Schwarz E I, Schlatzer C, Brack T,
Brutsche M, Frey M, Irani S, Leuppi J D, Rüdiger J, Thurnheer R, Kohler
M. Accuracy of the hospital anxiety and depression scale for identifying
depression in chronic obstructive pulmonary disease patients. Pulm Med
2014; 2014:973858.
Schönmann M, Sievi N A, Clarenbach C F, Brack T, Brutsche M, Frey M,
Irani S, Leuppi J D, ruediger j, Senn O, Thurnheer R, Kohler M. Physical
activity and the frequency of acute exacerbations in patients with chronic
obstructive pulmonary disease. Lung 2014; 193:63-70.
Dusemund F, Baty F, Brutsche M. Significant reduction of AECOPD
hospitalisations after implementation of a public smoking ban in
Graubunden, Switzerland. Tob Control 2014;.
Maeder M T, Strobel W, Christ M, Todd J, Estis J, Wildi K, Thalmann G,
Hilti J, Brutsche M, Twerenbold R, Rickli H, Mueller C. Comprehensive
biomarker profiling in patients with obstructive sleep apnea. Clin Biochem
2014;.
17Publikationen
Titel
Wissensch- Baty F, Putora P M, Isenring B, Blum T, Brutsche M. Comorbidities and
aftlicher Burden of COPD: A Population Based Case-Control Study. PLoS ONE
Artikel/ 2013; 8:e63285.
Review Schwitter M, Früh M, Schneider T, Kluckert J T, Rodriguez R, Brutsche M.
Epidermal Growth Factor Receptor Mutation in a Patient with Squamous
Cell Carcinoma of the Lung: Who Should Be Tested?. Oncology 2013;
2013:263-268.
Bontognali S, Pless M, Brutsche M, Fischer C, Rochlitz C, Buess M.
Analysis of the EGFR Mutation Status in Head and Neck Squamous Cell
Carcinoma before Treatment with Gefitinib. Onkologie 2013; 36:161-6.
Baty F, Rothschild S, Früh M, Betticher D, Dröge C, Cathomas R, Rauch D,
Gautschi O, Bubendorf L, Crowe S, Zappa F, Pless M, Brutsche M, Swiss
Group for Clinical Cancer Research . EGFR Exon-Level Biomarkers of the
Response to Bevacizumab/Erlotinib in Non-Small Cell Lung Cancer. PLoS
ONE 2013; 8:e72966.
finger r, Rodriguez R, Schönegg R, Kluckert J T, Brutsche M. Sarkoidose:
ein klinisch orientierter Überblick. Schweizerisches Medizin Forum
2013;265-270.
Russi E W, Karrer W, Brutsche M, Eich C, Fitting J W, Frey M, Geiser T,
Kuhn M, Nicod L, Quadri F, Rochat T, Steurer-Stey C, Stolz D. Diagnosis
and management of chronic obstructive pulmonary disease: the swiss
guidelines: official guidelines of the Swiss Respiratory Society. Respiration
2013; 85:160-74.
Baty F, ruediger j, Miglino N, Kern L, Borger P, Brutsche M. Exploring the
transcription factor activity in high-throughput gene expression data
using RLQ analysis. BMC Bioinformatics 2013; 14:178.
18Publikationen
Titel
Wissensch- dusemund f, Weber M D, nagel w, Schneider T, Brutsche M, Schoch O.
aftlicher Characteristics of medically and surgically treated empyema patients: a
Artikel/ retrospective cohort study. Respiration 2013; 86:288-94.
Review Schoch O, Baty F, Niedermann J, ruediger j, Brutsche M. Baseline
predictors of adherence to positive airway pressure therapy for sleep
apnea: a 10-year single-center observational cohort study. Respiration
2013; 87:121-8.
Schwitter M, Rodriguez R, Schneider T, Kluckert T, Brutsche M, Früh M.
Epidermal growth factor receptor mutation in a patient with squamous
cell carcinoma of the lung: who should be tested?. Case Rep Oncol 2013;
6:263-8.
Dusemund F, Schneider T, zeisel c, Rothermundt C, Kluckert T, schmid s,
Brutsche M. Endobronchial ultrasound-guided transbronchial needle
aspiration of an intravascular sarcoma metastasis. Respiration 2013;
86:430-432.
hochstrasser a, Benz G, Joerger M, templeton a, Brutsche M, Früh M.
Interstitial Pneumonitis after Treatment with Pemetrexed: A Rare Event?.
Chemotherapy 2012; 58:84-88.
Gautschi O, Dingemans A M, Crowe S, Peters S, Roder H, Grigorieva J,
Roder J, Zappa F, Pless M, Brutsche M, Baty F, Bubendorf L, Hsu Schmitz
S F, Na K J, Carbone D, Stahel R, Smit E. VeriStrat® has a prognostic
value for patients with advanced non-small cell lung cancer treated with
erlotinib and bevacizumab in the first line: pooled analysis of SAKK19/05
and NTR528. Lung Cancer 2012; 79:59-64.
Miglino N, Roth M, Baty F, Brutsche M, Tamm M, Borger P. Asthma and
the regulated retrotransposon transcriptome. Eur Respir J 2012;
40:788-90.
19Publikationen
Titel
Wissensch- Hostettler K E, Studler U, Tamm M, Brutsche M. Long-term treatment
aftlicher with infliximab in patients with sarcoidosis. Respiration 2011; 83:218-24.
Artikel/
Review Robert J, Brutsche M. Management of parapneumonic effusion and
empyema: medical thoracoscopy and surgical approach. Respiration
2011; 82:193-6.
Trachsel D, Brutsche M, Hug-Batschelet H, Hammer J. Progressive static
pulmonary hyperinflation in survivors of severe bronchopulmonary
dysplasia by mid-adulthood. Thorax 2011;.
Putora P M, Benz G, Rodriguez R, Brutsche M, Früh M. Tracheal
granuloma pyogenicum with erlotinib treatment for lung cancer. Eur
Respir J 2011; 38:1228-30.
Chhajed P N, Somandin S, Baty F, Mehta A J, Azzola A, Leuppi J, Tamm
M, Brutsche M. Therapeutic bronchoscopy for malignant airway stenoses:
choice of modality and survival. J Cancer Res Ther 2010; 6:204-9.
Brutsche M. Raucherentwöhnung: Mehr "Tech" für ein altes Problem?.
Leading Opinions Hämatologie & Onkologie 2010;.
Maeder M T, Staub D, Brutsche M, Arenja N, Socrates T, Reiter M,
Meissner J, Morgenthaler N G, Bergmann A, Struck J, Mueller C. Copeptin
response to clinical maximal exercise tests. Clin Chem 2010; 56:674-6.
Baty F, Facompré M, Kaiser S, Schumacher M, Pless M, Bubendorf L,
Savic S, Marrer E, Budach W, Buess M, Kehren J, Tamm M, Brutsche M.
Gene profiling of clinical routine biopsies and prediction of survival in
non-small cell lung cancer. American journal of respiratory and critical
care medicine 2010; 181:181-8.
20Publikationen
Titel
Wissensch- Brutsche M. Behandlung des Pleuraempyems mittels internistischer
aftlicher Thorakoskopie. Der Pneumologe 2010; 7:349-356.
Artikel/ Tueller C, Azzola A, Baty F, Condrau S, Wiegand J, Tamm M, Brutsche M.
Review Six-minute walk test enhanced by mobile telemetric cardiopulmonary
monitoring. Respiration 2010; 80:410-8.
Maeder M T, Brutsche M, Arenja N, Socrates T, Reiter M, Meissner J,
Staub D, Morgenthaler N G, Bergmann A, Mueller C. Biomarkers and
peak oxygen uptake in patients with chronic lung disease. Respiration
2010; 80:543-52.
Bridevaux P O, Probst-Hensch N M, Schindler C, Curjuric I, Felber Dietrich
D, Braendli O, Brutsche M, Burdet L, Frey M, Gerbase M W, Ackermann-
Liebrich U, Pons M, Tschopp J M, Rochat T, Russi E W. Prevalence of
airflow obstruction in smokers and never-smokers in Switzerland. Eur
Respir J 2010; 36:1259-69.
Grossman P, Wilhelm F H, Brutsche M. Accuracy of ventilatory
measurement employing ambulatory inductive plethysmography during
tasks of everyday life. Biol Psychol 2010; 84:121-8.
Curjuric I, Zemp E, Dratva J, Ackermann-Liebrich U, Bridevaux P O,
Bettschart R W, Brutsche M, Frey M, Gerbase M W, Knöpfli B, Künzli N,
Pons M, Schwartz J, Schindler C, Rochat T, SAPALDIA team .
Determinants of change in airway reactivity over 11 years in the
SAPALDIA population study. Eur Respir J 2010; 37:492-500.
21Publikationen
Titel
Wissensch- Schindler C, Keidel D, Gerbase M W, Zemp E, Bettschart R, Brändli O,
aftlicher Brutsche M, Burdet L, Karrer W, Knöpfli B, Pons M, Rapp R, Bayer-
Artikel/ Oglesby L, Künzli N, Schwartz J, Liu L J S, Ackermann-Liebrich U, Rochat
Review T, SAPALDIA Team . Improvements in PM10 exposure and reduced rates
of respiratory symptoms in a cohort of Swiss adults (SAPALDIA).
American journal of respiratory and critical care medicine 2009;
179:579-87.
Mueller C, Maeder M T, Christ A, Reichlin T, Staub D, Noveanu M,
Breidthardt T, Potocki M, Brutsche M. B-type natriuretic peptides for the
evaluation of exercise intolerance. The American journal of medicine
2009; 122:265-72.
Maeder M T, Brutsche M, Staub D, Morgenthaler N G, Bergmann A,
Noveanu M, Laule K, Breidthardt T, Christ A, Klima T, Reichlin T, Potocki
M, Mueller C. B-type natriuretic peptide and C-terminal-pro-endothelin-1
for the prediction of severely impaired peak oxygen consumption. Journal
of internal medicine 2009; 265:604-15.
Maeder M T, Brutsche M, Christ A, Reichlin T, Staub D, Noveanu M,
Breidthardt T, Potocki M, Mueller C. Natriuretic peptides for the prediction
of severely impaired peak VO2 in patients with lung disease. Respiratory
medicine 2009; 103:1337-45.
Deubelbeiss U, Gemperli A, Schindler C, Baty F, Brutsche M. Prevalence
of sarcoidosis in Switzerland is associated with environmental factors.
The European respiratory journal : official journal of the European
Society for Clinical Respiratory Physiology 2009;.
Maurer M, Simonett D, Brutsche M. Challenge of exercise-induced asthma
and exercise-induced bronchoconstriction. Expert Rev Respir Med 2009;
3:13-9.
22Publikationen
Titel
Wissensch- Probst-Hensch N M, Curjuric I, Bridevaux P O, Ackermann-Liebrich U A,
aftlicher Bettschart R W, Brändli O, Brutsche M, Burdet L, Gerbase M W, Knöpfli B,
Artikel/ Künzli N, Pons M G, Schindler C, Tschopp J M, Rochat T, Russi E W.
Review Longitudinal Change of Pre-Bronchodilator Spirometric Obstruction and
Health Outcomes -Results from the Sapaldia Cohort. Thorax 2009;.
Maeder M T, Brutsche M, Christ A, Staub D, Noveanu M, Breidthardt T,
Schaub N, Potocki M, Reichlin T, Morgenthaler N G, Bergmann A, Mueller
C. Midregional pro-A-type natriuretic peptide for the evaluation of
exercise intolerance. International journal of cardiology 2009;.
Brutsche M, Grossman P, Müller R E, Wiegand J, Pello , Baty F, Ruch W.
Impact of laughter on air trapping in severe chronic obstructive lung
disease. International journal of chronic obstructive pulmonary disease
2008; 3:185-92.
Jankovic D, Gorello P, Liu T, Ehret S, La Starza R, Desjobert C, Baty F,
Brutsche M, Jayaraman P S, Santoro A, Mecucci C, Schwaller J.
Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute
myeloid leukemia. Blood 2008; 111:5672-82.
Schuetz P, Christ-Crain M, Schild U, Süess E, Facompre M, Baty F,
Nusbaumer C, Brutsche M, Müller B. Effect of a 14-day course of
systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in
patients with acute exacerbation of chronic obstructive pulmonary
disease. BMC pulmonary medicine 2008; 8:1.
Baty F, Jaeger D, Preiswerk F, Schumacher M M, Brutsche M. Stability of
gene contributions and identification of outliers in multivariate analysis of
microarray data. BMC bioinformatics 2008; 9:289.
23Publikationen
Titel
Wissensch- Stolz D, Rasch H, Linka A, Di Valentino M, Meyer A, Brutsche M, Tamm M.
aftlicher A randomised, controlled trial of bosentan in severe COPD. The European
Artikel/ respiratory journal : official journal of the European Society for Clinical
Review Respiratory Physiology 2008; 32:619-28.
Imboden M, Rochat T, Brutsche M, Schindler C, Downs S H, Gerbase M W,
Berger W, Probst-Hensch N M, SAPALDIA Team . Glutathione S-
transferase genotype increases risk of progression from bronchial
hyperresponsiveness to asthma in adults. Thorax 2008; 63:322-8.
Gabrijel S, Grize L, Helfenstein E, Brutsche M, Grossman P, Tamm M, Kiss
A. Receiving the diagnosis of lung cancer: patient recall of information
and satisfaction with physician communication. Journal of clinical
oncology : official journal of the American Society of Clinical Oncology
2008; 26:297-302.
Breitenbücher A, Chhajed P N, Brutsche M, Mordasini C, Schilter D, Tamm
M. Long-term follow-up and survival after Ultraflex stent insertion in the
management of complex malignant airway stenoses. Respiration;
international review of thoracic diseases 2008; 75:443-9.
Pless M, Gambazzi F, Stillhart P, Lieb T, Brutsche M. Induction
chemotherapy followed by parenchyma-sparing surgery in medically
inoperable NSCLC-results of a feasibility study. Lung cancer (Amsterdam,
Netherlands) 2008; 62:228-35.
Downs S H, Schindler C, Liu L J S, Keidel D, Bayer-Oglesby L, Brutsche
M, Gerbase M W, Keller R, Künzli N, Leuenberger P, Probst-Hensch N M,
Tschopp J M, Zellweger J P, Rochat T, Schwartz J, Ackermann-Liebrich U,
SAPALDIA Team . Reduced exposure to PM10 and attenuated age-related
decline in lung function. The New England journal of medicine 2007;
357:2338-47.
24Publikationen
Titel
Wissensch- Reichenberger F, Kleiber B, Baschiera B, Bubendorf L, Brutsche M,
aftlicher Dalquen P, Tamm M. Bronchoalveolar lavage quality influences the T4/T8
Artikel/ ratio in sarcoidosis. Respiratory medicine 2007; 101:2025-30.
Review Schmid A, Schilter D, Fengels I, Chhajed P N, Strobel W, Tamm M,
Brutsche M. Design and validation of an interpretative strategy for
cardiopulmonary exercise tests. Respirology (Carlton, Vic.) 2007;
12:916-23.
Etter R, Brutsche M, Huegli R W, Borer H. [A rare cause of dyspnea on
exertion. A 76-year-old retired woman]. Praxis 2006; 95:1332-4.
Baughman R P, Drent M, Kavuru M, Judson M A, Costabel U, du Bois R,
Albera C, Brutsche M, Davis G, Donohue J F, Müller-Quernheim J,
Schlenker-Herceg R, Flavin S, Lo K H, Oemar B, Barnathan E S,
Sarcoidosis Investigators . Infliximab therapy in patients with chronic
sarcoidosis and pulmonary involvement. American journal of respiratory
and critical care medicine 2006; 174:795-802.
Baty F, Facompré M, Wiegand J, Schwager J, Brutsche M. Analysis with
respect to instrumental variables for the exploration of microarray data
structures. BMC bioinformatics 2006; 7:422.
Wiegand J A, Brutsche M. Sarcoidosis is a multisystem disorder with
variable prognosis--information for treating physicians. Swiss medical
weekly : official journal of the Swiss Society of Infectious Diseases, the
Swiss Society of Internal Medicine, the Swiss Society of Pneumology
2006; 136:203-9.
Chhajed P N, Baty F, Pless M, Somandin S, Tamm M, Brutsche M.
Outcome of treated advanced non-small cell lung cancer with and without
central airway obstruction. Chest 2006; 130:1803-7.
25Publikationen
Titel
Wissensch- Bihl M P, Laule-Kilian K, Bubendorf L, Rutherford R M, Baty F, Kehren J,
aftlicher Eryüksel E, Staedtler F, Yang J Q, Goulet S, Gilmartin J J, Tamm M,
Artikel/ Brutsche M. Progressive pulmonary sarcoidosis--a fibroproliferative
Review process potentially triggered by EGR-1 and IL-6. Sarcoidosis, vasculitis,
and diffuse lung diseases : official journal of WASOG / World Association
of Sarcoidosis and Other Granulomatous Disorders 2006; 23:38-50.
Brutsche M, Downs S H, Schindler C, Gerbase M W, Schwartz J, Frey M,
Russi E W, Ackermann-Liebrich U, Leuenberger P, SAPALDIA Team .
Bronchial hyperresponsiveness and the development of asthma and
COPD in asymptomatic individuals: SAPALDIA cohort study. Thorax 2006;
61:671-7.
Chhajed P N, Eberhardt R, Dienemann H, Azzola A, Brutsche M, Tamm M,
Herth F J F. Therapeutic bronchoscopy interventions before surgical
resection of lung cancer. The Annals of thoracic surgery 2006;
81:1839-43.
attinger a, Tüller C, Souren T, Tamm M, Schindler C, Brutsche M.
Feasibility of mobile cardiopulmonary exercise testing. Swiss Med Wkly
2006; 136:13-8.
Imboden M, Nieters A, Bircher A J, Brutsche M, Becker N, Wjst M,
Ackermann-Liebrich U, Berger W, Probst-Hensch N M, SAPALDIA Team .
Cytokine gene polymorphisms and atopic disease in two European
cohorts. (ECRHS-Basel and SAPALDIA). Clinical and molecular allergy :
CMA 2006; 4:9.
Kardos P, Brutsche M, Buhl R, Gillissen A, Rabe K F, Russi E W, Sauer R,
Worth H, Menz G. [Combination of asthma and COPD: more frequent as
considered to be?]. Pneumologie (Stuttgart, Germany) 2006; 60:366-72.
26Publikationen
Titel
Wissensch- Baty F, Bihl M P, Perrière G, Culhane A C, Brutsche M. Optimized
aftlicher between-group classification: a new jackknife-based gene selection
Artikel/ procedure for genome-wide expression data. BMC bioinformatics 2005;
Review 6:239.
Chhajed P N, Wallner J, Stolz D, Baty F, Strobel W, Brutsche M, Tamm M.
Sedative drug requirements during flexible bronchoscopy. Respiration;
international review of thoracic diseases 2005; 72:617-21.
Ackermann-Liebrich U, Kuna-Dibbert B, Probst-Hensch N M, Schindler C,
Felber Dietrich D, Stutz E Z, Bayer-Oglesby L, Baum F, Brändli O,
Brutsche M, Downs S H, Keidel D, Gerbase M W, Imboden M, Keller R,
Knöpfli B, Künzli N, Nicod L, Pons M, Staedele P, Tschopp J M, Zellweger J
P, Leuenberger P, SAPALDIA Team . Follow-up of the Swiss Cohort Study
on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003:
methods and characterization of participants. Sozial- und
Präventivmedizin 2005; 50:245-63.
Leuppi J D, Tandjung R, Anderson S D, Stolz D, Brutsche M, Bingisser R,
Perruchoud A P, Surber C, Knoblauch A, Andersson M, Greiff L, Chan H K,
Tamm M. Prediction of treatment-response to inhaled corticosteroids by
mannitol-challenge test in COPD. A proof of concept. Pulmonary
pharmacology & therapeutics 2005; 18:83-8.
Brutsche M, Tassi G F, Györik S, Gökcimen M, Renard C, Marchetti G P,
Tschopp J M. Treatment of sonographically stratified multiloculated
thoracic empyema by medical thoracoscopy. Chest 2005; 128:3303-9.
Kralovics R, Teo S S, Buser A S, Brutsche M, Tiedt R, Tichelli A,
Passamonti F, Pietra D, Cazzola M, Skoda R C. Altered gene expression in
myeloproliferative disorders correlates with activation of signaling by the
V617F mutation of Jak2. Blood 2005; 106:3374-6.
27Publikationen
Titel
Wissensch- Waechter F, Passweg J, Tamm M, Brutsche M, Herrmann R, Pless M.
aftlicher Significant progress in palliative treatment of non-small cell lung cancer
Artikel/ in the past decade. Chest 2005; 127:738-47.
Review Sollberger M, Fluri F, Baumann T, Sonnet S, Tamm M, Steck A J, Brutsche
M. Successful treatment of steroid-refractory neurosarcoidosis with
infliximab. Journal of neurology 2004; 251:760-1.
Rutherford R M, Brutsche M, Kearns M, Bourke M, Stevens F, Gilmartin J
J. HLA-DR2 predicts susceptibility and disease chronicity in Irish
sarcoidosis patients. Sarcoidosis, vasculitis, and diffuse lung diseases :
official journal of WASOG / World Association of Sarcoidosis and Other
Granulomatous Disorders 2004; 21:191-8.
Stolz D, Chhajed P N, Leuppi J D, Brutsche M, Pflimlin E, Tamm M. Cough
suppression during flexible bronchoscopy using combined sedation with
midazolam and hydrocodone: a randomised, double blind, placebo
controlled trial. Thorax 2004; 59:773-6.
Rutherford R M, Brutsche M, Kearns M, Bourke M, Stevens F, Gilmartin J
J. Prevalence of coeliac disease in patients with sarcoidosis. European
journal of gastroenterology & hepatology 2004; 16:911-5.
Joos L, Carlen Brutsche I E A, Laule-Kilian K, Crawen M, Tamm M,
Brutsche M. Systemic Th1- and Th2-gene signals in atopy and asthma.
Swiss medical weekly : official journal of the Swiss Society of Infectious
Diseases, the Swiss Society of Internal Medicine, the Swiss Society of
Pneumology 2004; 134:159-64.
Chhajed P N, Brutsche M, Tamm M. Balloon dilatation using flexible
bronchoscopy for the management of benign and malignant airway
stenoses. Chest 2004; 125:354-5.
28Publikationen
Titel
Wissensch- Rutherford R M, Staedtler F, Kehren J, Chibout S D, Joos L, Tamm M,
aftlicher Gilmartin J J, Brutsche M. Functional genomics and prognosis in
Artikel/ sarcoidosis--the critical role of antigen presentation. Sarcoidosis,
Review vasculitis, and diffuse lung diseases : official journal of WASOG / World
Association of Sarcoidosis and Other Granulomatous Disorders 2004;
21:10-8.
Györik S A, Brutsche M. Complementary and alternative medicine for
bronchial asthma: is there new evidence?. Current opinion in pulmonary
medicine 2004; 10:37-43.
Mueller C, Hodgson J M, Brutsche M, Bestehorn H P, Marsch S,
Perruchoud A P, Roskamm H, Buettner H J. Operator experience and long
term outcome after percutaneous coronary intervention. The Canadian
journal of cardiology 2003; 19:1047-51.
Mueller C, Hodgson J M, Bestehorn H P, Brutsche M, Perruchoud A P,
Marsch S, Roskamm H, Buettner H J. Previous cytomegalovirus infection
and restenosis after aggressive angioplasty with provisional stenting.
Journal of interventional cardiology 2003; 16:307-13.
Leuppi J D, Salzberg M, Meyer L, Bucher S E, Nief M, Brutsche M, Tamm
M. An individualized, adjustable maintenance regimen of budesonide/
formoterol provides effective asthma symptom control at a lower overall
dose than fixed dosing. Swiss medical weekly : official journal of the
Swiss Society of Infectious Diseases, the Swiss Society of Internal
Medicine, the Swiss Society of Pneumology 2003; 133:302-9.
Diacon A H, Brutsche M, Solèr M. Accuracy of pleural puncture sites: a
prospective comparison of clinical examination with ultrasound. Chest
2003; 123:436-41.
29Publikationen
Titel
Wissensch- Brutsche M. Notice of retraction. Swiss medical weekly : official journal of
aftlicher the Swiss Society of Infectious Diseases, the Swiss Society of Internal
Artikel/ Medicine, the Swiss Society of Pneumology 2003; 133:630.
Review Joos L, Eryüksel E, Brutsche M. Functional genomics and gene
microarrays--the use in research and clinical medicine. Swiss medical
weekly : official journal of the Swiss Society of Infectious Diseases, the
Swiss Society of Internal Medicine, the Swiss Society of Pneumology
2003; 133:31-8.
Stürchler M S, Brutsche M. [Cough and dyspnea during exertion 14 days
after nicotine use]. Praxis 2002; 91:568-70.
Brutsche M, Joos L, Carlen Brutsche I E A, Bissinger R, Tamm M, Custovic
A, Woodcock A. Array-based diagnostic gene-expression score for atopy
and asthma. The Journal of allergy and clinical immunology 2002;
109:271-3.
Brutsche M, Joos L. A new dimension for beta2 -adrenoceptor gene
polymorphisms. Pharmacogenetics 2002; 12:345-6.
Mueller C, Mc Hodgson J B, Brutsche M, Perruchoud A P, Marsch S,
Hunziker P, Buettner H J. Impact of intracoronary ultrasound guidance on
long-term outcome of percutaneous coronary interventions in diabetics--
insights from the randomized SIPS trial. Swiss medical weekly : official
journal of the Swiss Society of Infectious Diseases, the Swiss Society of
Internal Medicine, the Swiss Society of Pneumology 2002; 132:279-84.
Brutsche M. Complementary and alternative medicine in asthma--safety,
effectiveness and costs. Swiss medical weekly : official journal of the
Swiss Society of Infectious Diseases, the Swiss Society of Internal
Medicine, the Swiss Society of Pneumology 2002; 132:329-31.
30Publikationen
Titel
Wissensch- Mogulkoc N, Brutsche M, Bishop P W, Murby B, Greaves M S, Horrocks A
aftlicher W, Wilson M, McCullough C, Prescott M, Egan J J, Greater Manchester
Artikel/ Pulmonary Fibrosis Consortium . Pulmonary (99m)Tc-DTPA aerosol
Review clearance and survival in usual interstitial pneumonia (UIP). Thorax
2001; 56:916-23.
Brutsche M, Brutsche M, Wood P, Mogulkoc N, Custovic A, Egan J,
Woodcock A. B-cell isotype control in atopy and asthma assessed with
cDNA array technology. American journal of physiology. Lung cellular and
molecular physiology 2001; 280:L627-37.
Smillie F I, Elderfield A J, Patel F, Cain G, Tavenier G, Brutsche M, Craven
M, Custovic A, Woodcock A. Lymphoproliferative responses in cord blood
and at one year: no evidence for the effect of in utero exposure to dust
mite allergens. Clinical and experimental allergy : journal of the British
Society for Allergy and Clinical Immunology 2001; 31:1194-204.
Rutherford R M, Kehren J, Staedtler F, Chibout S D, Egan J J, Tamm M,
Gilmartin J J, Brutsche M. Functional genomics in sarcoidosis--reduced or
increased apoptosis?. Swiss medical weekly : official journal of the Swiss
Society of Infectious Diseases, the Swiss Society of Internal Medicine, the
Swiss Society of Pneumology 2001; 131:459-70.
Däweritz C, Brutsche M. [Young man with exercise-induced dyspnea].
Praxis 2001; 90:1783-5.
Steinke K, Brutsche M, Wiesner W. [Ovarian hyperstimulation syndrome
(OHSS): a radiologically little known complication of the hormonal
treatment of infertility]. RöFo : Fortschritte auf dem Gebiete der
Röntgenstrahlen und der Nuklearmedizin 2001; 173:274-5.
31Publikationen
Titel
Wissensch- Brutsche M, Brutsche M, Wood P, Brass A, Morrison N, Rattay M,
aftlicher Mogulkoc N, Simler N, Craven M, Custovic A, Egan J J, Woodcock A.
Artikel/ Apoptosis signals in atopy and asthma measured with cDNA arrays.
Review Clinical and experimental immunology 2001; 123:181-7.
Mogulkoc N, Brutsche M, Bishop P W, Greaves S M, Horrocks A W, Egan J
J, Greater Manchester Pulmonary Fibrosis Consortium . Pulmonary
function in idiopathic pulmonary fibrosis and referral for lung
transplantation. American journal of respiratory and critical care medicine
2001; 164:103-8.
Sistek D, Tschopp J M, Schindler C, Brutsche M, Ackermann-Liebrich U,
Perruchoud A P, Leuenberger P. Clinical diagnosis of current asthma:
predictive value of respiratory symptoms in the SAPALDIA study. Swiss
Study on Air Pollution and Lung Diseases in Adults. The European
respiratory journal : official journal of the European Society for Clinical
Respiratory Physiology 2001; 17:214-9.
Brutsche M, Spiliopoulos A, Bolliger C T, Licker M, Frey J G, Tschopp J M.
Exercise capacity and extent of resection as predictors of surgical risk in
lung cancer. The European respiratory journal : official journal of the
European Society for Clinical Respiratory Physiology 2000; 15:828-32.
Brutsche M, Diacon A, Droll A, Dalquen P, Solèr M. Pleural Kaposi's
sarcoma: a potentially overlooked manifestation. Respiration;
international review of thoracic diseases 2000; 67:444.
Brutsche M, Brutsche M, Munawar M, Langley S J, Masterson C M, Daley-
Yates P T, Brown R, Custovic A, Woodcock A. Comparison of
pharmacokinetics and systemic effects of inhaled fluticasone propionate
in patients with asthma and healthy volunteers: a randomised crossover
study. Lancet 2000; 356:556-61.
32Publikationen
Titel
Wissensch- Custovic A, Simpson B M, Simpson A, Hallam C, Craven M, Brutsche M,
aftlicher Woodcock A. Manchester Asthma and Allergy Study: low-allergen
Artikel/ environment can be achieved and maintained during pregnancy and in
Review early life. The Journal of allergy and clinical immunology 2000;
105:252-8.
Charvat J C, Brutsche M, Frey J G, Tschopp J M. [Value of thoracoscopy
and talc pleurodesis in diagnosis and palliative treatment of malignant
pleural mesothelioma]. Praxis 1998; 87:336-40.
Tschopp J M, Sistek D, Schindler C, Leuenberger P, Perruchoud A P,
Wüthrich B, Brutsche M, Zellweger J P, Karrer W, Brändli O. Current
allergic asthma and rhinitis: diagnostic efficiency of three commonly used
atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329
randomized adults from the SAPALDIA Study. Swiss Study on Air Pollution
and Lung Diseases in Adults. Allergy 1998; 53:608-13.
Tschopp J M, Brutsche M, Frey J G. Treatment of complicated
spontaneous pneumothorax by simple talc pleurodesis under
thoracoscopy and local anaesthesia. Thorax 1997; 52:329-32.
Tschopp J M, Brutsche M, Frey J G, Spiliopoulos A, Nicod L, Rochat T,
Morel P. End-stage cystic fibrosis: improved diabetes control 2 years after
successful isolated pancreatic cell and double-lung transplantation. Chest
1997; 112:1685-7.
Tschopp J M, Brutsche M, Frey J G, Tatti B, Aymon E, Spiliopoulos A.
[Thoracic surgery for non-small cell lung cancer. Cost-benefit of its
management in specialized intermediate care]. Swiss surgery.
Supplement 1996; Suppl 1:46-51.
Charvat J C, Brutsche M, Imoberdorf R, Nanzer A. Does higher monocyte
count predict increased alcohol consumption?. American journal of
hematology 1995; 48:68-9.
33Publikationen
Titel
Wissensch- Brutsche M, Britschgi D, Dayer E, Tschopp J M. Exercise-induced
aftlicher bronchospasm (EIB) in relation to seasonal and perennial specific IgE in
Artikel/ young adults. Allergy 1995; 50:905-9.
Review Leuenberger P, Schwartz J, Ackermann-Liebrich U, Blaser K, Bolognini G,
Bongard J P, Brandli O, Braun P, Bron C, Brutsche M. Passive smoking
exposure in adults and chronic respiratory symptoms (SAPALDIA Study).
Swiss Study on Air Pollution and Lung Diseases in Adults, SAPALDIA
Team. American journal of respiratory and critical care medicine 1994;
150:1222-8.
Brutsche M, Steiner A, Noth D, Valli C. [Diarrhea, erythema nodosum,
arthralgia]. Schweizerische Rundschau für Medizin Praxis = Revue suisse
de médecine Praxis 1993; 82:946-8.
Brutsche M, Frey J G, Tschopp J M. [Campaign against smoking and the
general practitioner. Evaluation of a simple method allowing immediate
measurement of compliance with smoking cessation in the physicians
office]. Schweizerische Rundschau für Medizin Praxis = Revue suisse de
médecine Praxis 1993; 82:1234-8.
Vock P, Brutsche M, Nanzer A, Bärtsch P. Variable radiomorphologic data
of high altitude pulmonary edema. Features from 60 patients. Chest
1991; 100:1306-11.
Tüller C, Tüller D, Tamm M, Brutsche M. Hemodynamic effects of
endobronchial application of ornipressin versus terlipressin. Respiration;
international review of thoracic diseases 71:397-401.
Conen D, Schilter D, Bubendorf L, Brutsche M, Leuppi J D. Interstitial
lung disease in an intravenous drug user. Respiration; international
review of thoracic diseases 70:101-3.
34Publikationen
Titel
Wissensch- Bolliger C T, Breitenbuecher A, Brutsche M, Heitz M, Stanzel F. Use of
aftlicher studded Polyflex stents in patients with neoplastic obstructions of the
Artikel/ central airways. Respiration; international review of thoracic diseases
Review 71:83-7.
Buchkapitel Früh M ; Baty F ; Putora P M ; Brutsche M: Advances in Personalized
Cancer Management. In: Advances in Personalized Cancer Management.
London : Future Medicine Ltd, 2011.- ISBN 978-1-78084-068-0, S. 58-67
Konferenzp- Neumair P ; Joos L ; Warschkow R ; Ess S ; Hitz F ; Früh M ; Brutsche M
apier/ ; Baty F ; Krähenbühl S ; Joerger M: Chemotherapy is not superior to
Poster erlotinib in pretreated patients with advanced non-small cell lung cancer
(NSCLC): A retrospective study : Abstrakt 169P. In: J Thorac Oncol. 11(4
Suppl) : Elsevier, 2016.- European Lung Cancer Conference.- Geneva, S.
131
Ludwig P ; Putora P M ; Rogenmoser G ; Plasswilm L ; Baty F ; Brutsche
M: Factors influencing the success rates of smoking cessation
intervention. In: Swiss Med Wkly 2010; 140(Suppl 179) : Editores
Medicorum Helveticorum, 2010.- Joint annual meeting of the Swiss
Society of Pneumology, Swiss Society of Pediatric Pneumology, Swiss
Society for Thoracic Surgery.- Lausanne, S. 16-17S
Putora P M ; Baty F ; Ludwig P ; Rogenmoser G ; Plasswilm L ; Brutsche
M: The Influence of Malignancy and Referring Department on Smoking
Cessation Success. In: Journal of Thoracic Oncology 5:5 May 2010 : WK,
LWW, 2010.- 2nd European Lung Cancer Conference.- Geneva, CH, S. 53
Präsentation/ Löschhorn C ; Rodriguez R ; Schoch O ; Brutsche M: Hypersensitivity
Vortrag Pneumonitis induced by a CPAP Ventilator?. American Thoracic Society
(ATS) International Conference. New Orleans, LA, 2010
35Projekte
Titel Status
Predictive markers for checkpoint-based immunotherapy in Laufend
advanced non-small cell lung cancer -
Rekrutie-
rungsph-
ase
Prospective observational cohort study to investigate long-term Laufend
pulmonary and extrapulmonary effects of COVID-19 -
Rekrutie-
rungsph-
ase
COugh During and after acute EXacerbation of chronic Laufend
obstructive pulmonary disease (CODEX) study -
Rekrutie-
rungsph-
ase
Smartphone-Enabled Detection of COugh in COvid-19 (COCO): Automat-
An Exploratory, Single-Center, Observational Cohort Study ically
closed
Swiss Severe Asthma Register Laufend
-
Rekrutie-
rungsph-
ase
36Projekte
Titel Status
The role of physical activity, malnutrition and sarcopenia for the Laufend
prediction of acute exacerbations and the evolution of COPD -
assessment test (CAT) in patients with COPD Rekrutie-
rungsph-
ase
Asthma control Prediction Laufend
-
Rekrutie-
rungsph-
ase
37Projekte
Titel Status
Effect of induction chemotherapy on lung function measured by Geplant
spiroergometry and 6-Minute walking test in patients affected
by non-small cell lung cancer (NSCLC)
Azithromycin for the treatment of cough in idiopathic Laufend
pulmonary fibrosis -
Rekrutie-
rungsph-
ase
Prevalence and functional role of read-through fusion Laufend
transcripts in lung cancer -
Rekrutie-
rungsph-
ase
A randomised controlled, international, multicentre crossover Automat-
trial. We want to test, whether telehealthcare can improve ically
HRQOL and reduce emergency admissions and hospitalisations closed
due to AECOPD
38Projekte
Titel Status
A multicenter, randomized, 52-week, double-blind, parallel Geplant
group, active controlled study to compare the efficacy and
safety of QVM149 with QMF149 in patients with asthma
39Projekte
Titel Status
A 52-week, multicenter, randomized, double-blind, Geplant
placebocontrolled study to assess the efficacy and safety of
QAW039 when added to existing asthma therapy in patients
with uncontrolled severe asthma
Cardiopulmonary- and hemodynamic responses during positive Automat-
and negative airway pressure in patients with chronic ically
obstructive pulmonary disease closed
Characterizing sleep apnea by using a wearable electro EMPA Automat-
cardiogram device ically
closed
Cardiopulmonary- and hemodynamic responses during positive Automat-
and negative airway pressure in patients with chronic ically
obstructive pulmonary disease (COPD) closed
40Projekte
Titel Status
Predictive and prognostic value of integrated exon-level Automat-
expression to approach drug-response and resistance to EGFR- ically
targeted treatment in non-small cell lung cancer closed
LONGACT study Abgebro-
chen
PneumRx CLN0014 - Europäisches RePneu Register Abgebro-
chen
Kalydeco Geplant
Galathea Automat-
ically
closed
Telehealthcare in COPD - a Feasibility Trial Abgesch-
lossen
Blood pressure variability during the 6-minute walk test in Abgesch-
patients with Chronic Obstructive Pulmonary Disease (COPD): A lossen
case-control study
Tobramycin Abgesch-
lossen
Airway microbiota resistome in CF - impact on clinical Automat-
management ically
closed
Telemedicine to enhance CPAP adherence in OSAS - A Abgesch-
randomized placebo-controlled prospective study lossen
41Projekte
Titel Status
Genome-wide Gene/Exon expression analysis of late stage Abgesch-
NSCLC treated by Erlotinib /Bevacizumab: role of tumor-stroma lossen
interactions
RAINIER Abgesch-
lossen
Offene, nicht kontrollierte, multizentrische Phase IIIb Studie Abgebro-
zur Beurteilung von Riociguat (BAY 63-2521) bei Patienten mit chen
Chronisch Thromboembolischer Pulmonaler Hypertonie (CTEPH)
Improved adherence to CPAP by Telemetric Support in Newly Abgesch-
diagnosed OSAS Patients lossen
42Projekte
Titel Status
Immediate non-invasive ventilatory (NIV) support in patients Abgesch-
with severe respiratory failure on the emergency ward (ED)- lossen
Experience of a 6 months pilot
Systems biology approach to molecularly characterize the lung Abgesch-
cancer microenvironment lossen
43Projekte
Titel Status
A multicenter, reandomized, double-blind, single-dose study to Abgesch-
assess the effect of the combined inhalation of 150 ug lossen
indacaterol maleate (QAB149) and 50 ug glycopyrronium
bromide (NVA237) versus inhaled 150 ug indacaterol maleate
(QAB149) alone on inspiratory capacity in patients with
moderate or severe COPD
44Projekte
Titel Status
Circulating micro-RNA profiling in patients with advanced non- Abgesch-
squamous non small-cell lung cancer receiving bevacizumab/ lossen
erlotinib first-line treatment followed by platinum-based
chemotherapy at disease progression (SAKK 19/05)
Significant reduction of AECOPD hospitalizations after Abgesch-
implementation of a public smoking ban in Graubünden, lossen
Switzerland
Systembiologische Untersuchungen zur molekularen Abgesch-
Charakterisierung der Mikroumgebung in Lungentumoren lossen
Integrative Translational Research Network for Lung Cancer Abgesch-
(ITRNLC) lossen
The significance of Defensin alpha 4 in the pathophysiology of Abgebro-
the adrenal insufficiency in inflammatory lung diseases chen
The obstructive pulmonary disease outcomes cohort of Automat-
Switzerland (TOP DOCS): phenotypes and vascular amage in ically
COPD closed
A 24 week, randomized, double-blind, multicenter, placebo- Abgebro-
controlled efficacy, safety, tolerability and PK trial of Nilotinib chen
(AMN107) in pulmonary arterial hypertension (PAH)
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