Wissenschaftliche Publikationen 2017 - Kantonsspital St.Gallen
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Inhaltsverzeichnis Departement I ........................................................................................................... 4 Allgemeine Innere Medizin/Hausarztmedizin ........................................................................... 4 Angiologie ............................................................................................................................... 4 Endokrinologie/Diabetologie.................................................................................................... 4 Gastroenterologie/Hepatologie................................................................................................ 5 Infektiologie/Spitalhygiene ...................................................................................................... 6 Kardiologie .............................................................................................................................. 8 Onkologie/Hämatologie ......................................................................................................... 10 Pneumologie/Schlafmedizin .................................................................................................. 16 Psychosomatik ...................................................................................................................... 18 Rheumatologie ...................................................................................................................... 18 Departement II ........................................................................................................ 20 Anästhesiologie/Intensivmedizin ........................................................................................... 20 Klinik für Allgemein-, Viszeral-, Endokrin- und Transplantationschirurgie .............................. 21 Klinik für Gefässchirurgie ...................................................................................................... 22 Frauenklinik .......................................................................................................................... 23 Klinik für Orthopädische Chirurgie ......................................................................................... 24 Klinik für Urologie .................................................................................................................. 25 Departement III ....................................................................................................... 27 Augenklinik ........................................................................................................................... 27 Hals-Nasen-Ohrenklinik ........................................................................................................ 27 Neurochirurgie ...................................................................................................................... 27 Neurologie ............................................................................................................................ 29 Departement IV ....................................................................................................... 31 Pathologie ............................................................................................................................. 31 Radiologie und Nuklearmedizin ............................................................................................. 32 Radio-Onkologie ................................................................................................................... 33 Rechtsmedizin ...................................................................................................................... 34 Departement Interdisziplinäre Med. Dienste ........................................................ 35 Zentrale Notfallaufnahme ...................................................................................................... 35 Dermatologie/Allergologie ..................................................................................................... 35 Brustzentrum ........................................................................................................................ 37 Muskelzentrum/ALS clinic ..................................................................................................... 38 Institut für Immunbiologie ...................................................................................................... 39 Clinical Trials Unit ................................................................................................................. 40 Palliativzentrum..................................................................................................................... 41 Seite 1 von 41
Kantonsspital St.Gallen – Publikationen Am Kantonsspital St.Gallen wird klinische 400 Anzahl Publikationen Forschung und translationale Grundlagenforschung auf hohem Niveau 300 betrieben. Die Ergebnisse der Studien und Forschungsprojekte werden an 200 wissenschaftlichen Kongressen präsentiert 100 und in wissenschaftlichen Journalen publiziert. Um die Öffentlichkeit und die 0 Fachwelt über die Forschungsaktivitäten am 2015 2016 2017 Kantonsspital St.Gallen zu informieren, werden die Publikationen in der Forschungs- Journale ohne Impact Factor und Studiendatenbank systematisch erfasst Journale mit Impact Factor und ausgewertet (www.forschung.kssg.ch). Abb.1. Anzahl der Publikationen in Im Jahr 2017 wurden 372 Publikationen mit Journalen mit oder ohne Impact-Factor in Beteiligung von Forschenden des den Jahren 2015 – 2017 Kantonsspitals St.Gallen veröffentlicht. Von diesen Arbeiten wurden 303 in Journalen mit 350 6.5 7.0 Impact-Factor publiziert (Abb. 1). Der Publikationen mit Impact-Factor 300 6.0 Impact-Factor einer Fachzeitschrift gibt an, 5.1 Impact/Publikation [■] 4.8 wie oft ein Artikel aus dieser Zeitschrift von 250 5.0 anderen Forschenden zitiert wird. Für die 200 4.0 Berechnung des mittleren Impact-Faktors der Publikationen des Kantonsspital 150 3.0 St.Gallen, wurden Daten des Journal 100 2.0 Citation Reports aus dem Jahr 2016 verwendet. 50 1.0 258 323 303 Erneut konnten über 300 wissenschaftliche 0 0.0 Arbeiten in Zeitschriften mit Impakt-Faktor 2015 2016 2017 publiziert werden. Besonders erfreulich ist, Abb.2. Mittlere Qualität der Publikationen dass der mittlere Impact-Factor pro gemessen als durchschnittlicher Impact- Publikation auf 6.5 gestiegen ist. In Abb. 2 Factor pro Veröffentlichung sind die Daten der Jahre 2015-2017 gezeigt. Die Auswertung der Publikationsdaten nach 200 Anzahl Publikationen Medizinischen Departementen zeigt (Abb. 175 150 3), dass in allen Disziplinen intensiv 125 geforscht und publiziert wird. Grosse 100 Departemente, wie die Innere Medizin 75 (Med.Dept. I), steuern den Grossteil der 50 Publikationen bei. In Abbildung 3 ist die 25 Publikationstätigkeit der Jahre 2015 – 2017 0 15 16 17 15 16 17 15 16 17 15 16 17 15 16 17 in den einzelnen Departementen gezeigt. Dept. I Dept. II Dept. III Dept. IV IMD Detaillierte Auswertungen können beim Medizinischen Forschungszentrum (MFZ) In Journalen ohne Impact Factor angefordert werden. In Journalen mit Impact Factor Abb. 3. Publikationsstatistik in den Departementen I-IV und IMD in den Jahren 2015-2017 Seite 2 von 41
Die Publikationen wurden direkt aus der Forschungs- und Studiendatenbank des KSSG extrahiert (www.forschung.kssg.ch). Für die Vollständigkeit und Richtigkeit der Publikationen in der Datenbank tragen die Fachbereiche die Verantwortung. Durch Anklicken des Bereichs/Instituts wird man direkt auf die Publikationen in der Datenbank verlinkt. Seite 3 von 41
Departement I Allgemeine Innere Medizin/Hausarztmedizin Wissenschaftliche Artikel 1. Brändle M, Büche D, Nestor K. Hilfe beim Sterben, Hilfe zum Sterben oder Hilfe zum Leben? Sterbehilfe rechtlich, ethisch und palliativ betrachtet. Schweiz Med Forum 2017 2017; 17:738- 743. 2. Brenner R, Diethelm M, Maeder M T. Blutdruck und akutes Koronarsyndrom – Pathophysiologie, Prognose und Therapie. LEADING OPTIONS Innere Medizin 2017; 2017:18-20. 3. Dicker M, Schneider T, von Kempis J, Diethelm M. [A Rare Differential Diagnosis of Chronic Cough]. Dtsch Med Wochenschr 2017; 142:1751-1755. 4. Henz S, tapernoux d, Diethelm M, Bucher C, Fehr T, Propp S. Einfluss von Postmenopause, Sonnenlichtexposition, Arzneimitteln und Komorbiditätenauf Serumkalzium und Phosphat bei 13.000 Krankenhauspatienten*. Nieren- und Hochdruckkrankheiten 2017; 46:1-8. 5. Quarella M, Walser D, Brändle M, Fournier J Y, Bilz S. Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly. J Clin Endocrinol Metab 2017; 102:1451-1453. 6. Streuli R, Krull I, Brändle M, Kolb W, Stalla G, Theodoropoulou M, Enzler-Tschudy A, Bilz S. A rare case of an ACTH/CRH co-secreting midgut neuroendocrine tumor mimicking Cushing's disease. Endocrinol Diabetes Metab Case Rep 2017; 2017: 17-0058. Angiologie Wissenschaftliche Artikel 1. Benecke U, Koeger P. Blue-Finger-Syndrome and Tofacitinib. Annale of Clinical Case Reports - Rheumatology 2017; 2: Endokrinologie/Diabetologie Wissenschaftliche Artikel 1. Brändle M, Büche D, Nestor K. Hilfe beim Sterben, Hilfe zum Sterben oder Hilfe zum Leben? Sterbehilfe rechtlich, ethisch und palliativ betrachtet. Schweiz Med Forum 2017 2017; 17:738- 743. 2. Ding M, Huang T, Bergholdt H K, Nordestgaard B G, Ellervik C, Qi L, Renström F. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. BMJ 2017; 356:j1000. 3. Graff M, Scott R A, Justice A E, et al. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017; 13:e1006528. 4. Justice A E, Winkler T W, Feitosa M F, et al. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 2017; 8:14977. 5. Liu D J, Peloso G M, Yu H, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet 2017; 49:1758-1766. 6. Marouli E, Graff M, Medina-Gomez C, et al. Rare and low-frequency coding variants alter human adult height. Nature 2017; 542:186-190. 7. Quarella M, Walser D, Brändle M, Fournier J Y, Bilz S. Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly. J Clin Endocrinol Metab 2017; 102:1451-1453. 8. Streuli R, Krull I, Brändle M, Kolb W, Stalla G, Theodoropoulou M, Enzler-Tschudy A, Bilz S. A Seite 4 von 41
rare case of an ACTH/CRH co-secreting midgut neuroendocrine tumor mimicking Cushing's disease. Endocrinol Diabetes Metab Case Rep 2017; 2017: 17-0058. 9. Tognon G, Nilsson L M, Shungin D, Lissner L, Jansson J H, Renström F, Wennberg M, Winkvist A, Johansson I. Nonfermented milk and other dairy products: associations with all-cause mortality. Am J Clin Nutr 2017; 105:1502-1511. 10. Tümer Z, Petris M, Zhu S, Mercer J, Bukrinski J, Bilz S, Baerlocher K, Horn N, Møller L B. A 37- year-old Menkes disease patient-Residual ATP7A activity and early copper administration as key factors in beneficial treatment. Clin Genet 2017; 92:548-553. 11. van Duijnhoven F J B, Jenab M, Hveem K, Siersema P D, Fedirko V, Duell E J, Kampman E, Halfweeg A, van Kranen H J, van den Ouweland J M W, Weiderpass E, Murphy N, Langhammer A, Ness-Jensen E, Olsen A, Tjønneland A, Overvad K, Cadeau C, Kvaskoff M, Boutron-Ruault M C, Katzke V A, Kühn T, Boeing H, Trichopoulou A, Kotanidou A, Kritikou M, Palli D, Agnoli C, Tumino R, Panico S, Matullo G, Peeters P, Brustad M, Olsen K S, Lasheras C, Obón-Santacana M, Sánchez M J, Dorronsoro M, Chirlaque M D, Barricarte A, Manjer J, Almquist M, Renström F, Ye W, Wareham N, Khaw K T, Bradbury K E, Freisling H, Aune D, Norat T, Riboli E, Bueno-de- Mesquita H B. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. Int J Cancer 2017 [Epub ahead of print] 12. Vines L, Frick T, Aczel S, L'Allemand D, Borovicka J, Schiesser M. Linear stapled gastrojejunostomy results in fewer strictures compared to circular stapled gastrojejunostomy in laparoscopic gastric bypass surgery. Langenbecks Arch Surg 2017 [Epub ahead of print] 13. Winkvist A, Klingberg S, Nilsson L M, Wennberg M, Renström F, Hallmans G, Boman K, Johansson I. Longitudinal 10-year changes in dietary intake and associations with cardio- metabolic risk factors in the Northern Sweden Health and Disease Study. Nutr J 2017; 16:20. Gastroenterologie/Hepatologie Wissenschaftliche Artikel 1. Bernsmeier C, Albano E. Liver dendritic cells and NAFLD evolution: A remaining open issue. J Hepatol 2017; 66:1120-1122. 2. Bernsmeier C, Triantafyllou E, Brenig R, Lebosse F J, Singanayagam A, Patel V C, Pop O T, Khamri W, Nathwani R, Tidswell R, Weston C J, Adams D H, Thursz M R, Wendon J A, Antoniades C G. CD14+CD15-HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. Gut 2017;. 3. Bruggmann P, Blach S, Deltenre P, Fehr J, Kouyos R, Lavanchy D, Müllhaupt B, Rauch A, Razavi H, Schmid P, Semela D, Stoeckle M, Negro F. Hepatitis C virus dynamics among intravenous drug users suggest that an annual treatment uptake above 10% would eliminate the disease by 2030. Swiss Med Wkly 2017; 147:w14543. 4. Fraga M, Doerig C, Moulin H, Bihl F, Brunner F, Müllhaupt B, Ripellino P, Semela D, Stickel F, Terziroli Beretta-Piccoli B, Aubert V, Telenti A, Greub G, Sahli R, Moradpour D. Hepatitis E virus as a cause of acute hepatitis acquired in Switzerland. Liver Int 2017;. 5. Gauthiez E, Habfast-Robertson I, Rüeger S, Kutalik Z, Aubert V, Berg T, Cerny A, Gorgievski M, George J, Heim M H, Malinverni R, Moradpour D, Müllhaupt B, Negro F, Semela D, Semmo N, Villard J, Bibert S, Bochud P Y, Swiss Hepatitis C Cohort Study . A systematic review and meta- analysis of HCV clearance. Liver Int 2017; 37:1431-1445. 6. Greuter T, Vavricka S R, Biedermann L, Pilz J, Borovicka J, Seibold F, Sauter B, Rogler G. Alicaforsen, an Antisense Inhibitor of Intercellular Adhesion Molecule-1, in the Treatment for Left- Sided Ulcerative Colitis and Ulcerative Proctitis. Dig Dis 2017;. 7. Keiser O, Giudici F, Müllhaupt B, Junker C, Dufour J F, Moradpour D, Bruggmann P, Terziroli B, Semela D, Brezzi M, Bertisch B, Estill J, Negro F, Spoerri A, Swiss Hepatitis C Cohort Study and the Swiss National Cohort . Trends in hepatitis C-related mortality in Switzerland. J Viral Hepat 2017; 25:152-160. 8. Khamri W, Abeles R D, Hou T Z, Anderson A E, El-Masry A, Triantafyllou E, Bernsmeier C, Seite 5 von 41
Larsen F S, Singanayagam A, Kudo N, Possamai L A, Lebosse F, Auzinger G, Bernal W, Willars C, Weston C J, Lombardi G, Wendon J, Thursz M, Antoniades C G. Increased Expression of CTLA4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure. Gastroenterology 2017;. 9. Kolly P, Waidmann O, Vermehren J, Moreno C, Vögeli I, Berg T, Semela D, Zeuzem S, Dufour J F. Hepatocellular carcinoma recurrence after direct antiviral agent treatment: A European multicentre study. J Hepatol 2017; 67:876-878. 10. Lenggenhager D, Gouttenoire J, Malehmir M, Bawohl M, Honcharova-Biletska H, Kreutzer S, Semela D, Neuweiler J, Hürlimann S, Aepli P, Fraga M, Sahli R, Terracciano L, Rubbia-Brandt L, Müllhaupt B, Sempoux C, Moradpour D, Weber A. Visualization of hepatitis E virus RNA and proteins in the human liver. J Hepatol 2017; 67:471-479. 11. Marti L, Galata C, Beutner U, Hetzer F, Pipitone N, Wolff K, Borovicka J, Brunner W, Sulz M, Maurus C. Percutaneous tibial nerve stimulation (pTNS): success rate and the role of rectal capacity. Int J Colorectal Dis 2017; 32:789-796. 12. Terziroli Beretta-Piccoli B, Stirnimann G, Cerny A, Semela D, Hessler R, Helbling B, Stickel F, Kalid-de Bakker C, Bihl F, Giostra E, Filipowicz Sinnreich M, Oneta C, Baserga A, Invernizzi P, Carbone M, Mertens J. Geoepidemiology of Primary Biliary Cholangitis: Lessons from Switzerland. Clin Rev Allergy Immunol 2017;. 13. Török H P, Bellon V, Konrad A, Lacher M, Tonenchi L, Siebeck M, Brand S, De Toni E N. Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease. PLoS ONE 2017; 12:e0175180. 14. Triantafyllou E, Pop O T, Possamai L A, Wilhelm A, Liaskou E, Singanayagam A, Bernsmeier C, Khamri W, Petts G, Dargue R, Davies S P, Tickle J, Yuksel M, Patel V C, Abeles R D, Stamataki Z, Curbishley S M, Ma Y, Wilson I D, Coen M, Woollard K J, Quaglia A, Wendon J, Thursz M R, Adams D H, Weston C J, Antoniades C G. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut 2017;. 15. Vavricka S R, Spasojevic M, Rogler G, Schoepfer A M, Seibold F, Borovicka J, Frei P, Zeitz J, Greuter T, Manser C, Scharl M, Misselwitz B, Straumann A, Michetti P, Biedermann L,. Long- Term Efficacy and Safety of Certolizumab Pegol in an Unselected Crohn's Disease Population: The FACTS III Survey. Dig Dis 2017; 35:423-432. 16. Vines L, Frick T, Aczel S, L'allemand D, Borovicka J, Schiesser M. Linear stapled gastrojejunostomy results in fewer strictures compared to circular stapled gastrojejunostomy in laparoscopic gastric bypass surgery. Langenbecks Arch Surg 2017;. Infektiologie/Spitalhygiene Wissenschaftliche Artikel 1. Albrich W, Huttner B D, Huttner A. Validation of IDSA/ATS Algorithm for Duration of Pneumonia Therapy. JAMA Intern Med 2017; 177:283-284. 2. Bayard C, Ledergerber B, Flepp M, Lecompte T, Moulin E, Hoffmann M, Weber R, Staehelin C, Di Benedetto C, Fux C A, Tarr P E, Hasse B, Swiss HIV Cohort Study. Associations Between Antiretroviral Treatment and Avascular Bone Necrosis: The Swiss HIV Cohort Study. Open Forum Infect Dis 2017; 4:ofx177. 3. Béguelin C, Friolet N, Moradpour D, Sahli R, Suter-Riniker F, Lüthi A, Cavassini M, Günthard H F, Battegay M, Bernasconi E, Schmid P, Calmy A, Atkinson A, Rauch A, Wandeler G,. Impact of tenofovir on hepatitis delta virus replication in the Swiss HIV Cohort Study. Clin Infect Dis 2017;. 4. Béguelin C, Suter A, Bernasconi E, Fehr J, Kovari H, Bucher H C, Stoeckle M, Cavassini M, Rougemont M, Schmid P, Wandeler G, Rauch A, Swiss HIV Cohort Study . Trends in HCV treatment uptake, efficacy and impact on liver fibrosis in the Swiss HIV Cohort Study. Liver Int 2017;. 5. Böni C, Al-Sheikh M, Hasse B, Eberhard R, Kohler P, Hasler P, Erb S, Hoffmann M, Barthelmes D, Zweifel S A. MULTIMODAL IMAGING OF CHOROIDAL LESIONS IN DISSEMINATED Seite 6 von 41
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20. Salazar-Vizcaya L, Kouyos R D, Fehr J, Braun D, Estill J, Bernasconi E, Delaloye J, Stöckle M, Schmid P, Rougemont M, Wandeler G, Günthard H F, Keiser O, Rauch A, Swiss HIV Cohort Study . On the potential of a short-term intensive intervention to interrupt HCV transmission in HIV-positive men who have sex with men: A mathematical modelling study. J Viral Hepat 2017; 25:10-18. 21. Sculier D, Gayet-Ageron A, Battegay M, Cavassini M, Fehr J, Hirzel C, Schmid P, Bernasconi E, Calmy A, Swiss HIV Cohort Study . Rilpivirine use in the Swiss HIV cohort study: a prospective cohort study. BMC Infect Dis 2017; 17:476. 22. Shilaih M, Marzel A, Braun D L, Scherrer A U, Kovari H, Young J, Calmy A, Darling K, Battegay M, Hoffmann M, Bernasconi E, Thurnheer M C, Günthard H F, Kouyos R D,. Factors associated with syphilis incidence in the HIV-infected in the era of highly active antiretrovirals. Medicine (Baltimore) 2017; 96:e5849. 23. Sommerstein R, Kohler P, Hasse B. Global Mycobacterium chimaera outbreak: challenges for the near future. J Hosp Infect 2017; 96:207-208. 24. Strahm C, Albrich W, Zdravkovic V, Schöbi B, hildebrandt g, Schlegel M. Infection Rate after Cranial Neurosurgical Procedures: A Prospective Single-Center Study. World Neurosurg 2017;. 25. Turk T, Bachmann N, Kadelka C, Böni J, Yerly S, Aubert V, Klimkait T, Battegay M, Bernasconi E, Calmy A, Cavassini M, Furrer H, Hoffmann M, Günthard H F, Kouyos R D, Swiss HIV Cohort Study , Aubert V, Battegay M, Bernasconi E, Böni J, Braun D L, Bucher H C, Calmy A, Cavassini M, Ciuffi A, Dollenmaier G, Egger M, Elzi L, Fehr J, Fellay J, Furrer H, Fux C A, Günthard H F, Haerry D, Hasse B, Hirsch H H, Hoffmann M, Hösli I, Kahlert C R, Kaiser L, Keiser O, Klimkait T, Kouyos R D, Kovari H, Ledergerber B, Martinetti G, Martinez de Tejada B, Marzolini C, Metzner K J, Müller N, Nicca D, Pantaleo G, Paioni P, Rauch A, Rudin C, Scherrer A U, Schmid P, Speck R, Stöckle M, Tarr P, Trkola A, Vernazza P, Wandeler G, Weber R, Yerly S. Assessing the danger of self-sustained HIV epidemics in heterosexuals by population based phylogenetic cluster analysis. Elife 2017; 6:. 26. Zumstein V, Betschart P, Albrich W, Buhmann M, Ren Q, Schmid H P, Abt D. biofilm formation on ureteral stents. Swiss Med Forum 2017; 17 (7):174. 27. Zumstein V, Betschart P, Albrich W, Buhmann M T, Ren Q, Schmid H P, Abt D. Biofilm formation on ureteral stents - Incidence, clinical impact, and prevention. Swiss Med Wkly 2017; 147:w14408 Kardiologie Wissenschaftliche Artikel 1. Blum S, Muff C, Aeschbacher S, Ammann P, Erne P, Moschovitis G, di Valentino M, Shah D, Schläpfer J, Fischer A, Merkel T, Kühne M, Sticherling C, Osswald S, Conen D. Prospective Assessment of Sex-Related Differences in Symptom Status and Health Perception Among Patients With Atrial Fibrillation. J Am Heart Assoc 2017; 6:. 2. Boehnel C, Rickli H, Graf L, Maeder M T. Coronary angiography with or without percutaneous coronary intervention in patients with hemophilia-Systematic review. Catheter Cardiovasc Interv 2017;. 3. Brenner R, Ammann P, Yoon S I, Christen S, Hellermann J, Girod G, Knaus U, Duru F, Krasniqi N, Ramsay D, Sticherling C, Lippuner K, Kühne M. Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction. Europace 2017; 19:1220-1226. 4. Brenner R, Diethelm M, Maeder M T. Blutdruck und akutes Koronarsyndrom – Pathophysiologie, Prognose und Therapie. LEADING OPTIONS Innere Medizin 2017; 2017:18-20. 5. Burri H, Müller H, Kobza R, Sticherling C, Ammann P, Zerlik H, Stettler C, Klersy C, Prinzen F, Auricchio A. RIght VErsus Left Apical transvenous pacing for bradycardia: Results of the RIVELA randomized study. Indian Pacing Electrophysiol J 2017; 17:171-175. 6. Conen D, Rodondi N, Mueller A, Beer J, Auricchio A, Ammann P, Hayoz D, Kobza R, Moschovitis G, Shah D, Schlaepfer J, Novak J, di Valentino M, Erne P, Sticherling C, Bonati L, Ehret G, Roten Seite 8 von 41
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