Prof. Burkhard Ludewig - Kontakt - Research KSSG
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Prof. Burkhard Ludewig
Kontakt
Titel Prof. Dr.
Vorname Burkhard
Nachname Ludewig
Strasse Rorschacherstrasse 95
Stadt 9007 St. Gallen
Land Switzerland
Telefonnummer +41-71-494 1090
Fax +41-71-494 6321
E-Mail burkhard.ludewig@kssg.ch
Webseite www.kssg.ch/mfz/institut-fuer-
immunbiologieForschungsprofil
Akademischer Status Leitende(r) Arzt/Ärztin
Departement Interdisziplinäre Medizinische Dienste
Abteilung Institut für Immunbiologie
Position Leiter, Medizinisches Forschungszentrum
Leiter, Institut für Immunbiologie
Forschungsgebiet Immunologie, Virologie, Mathematische
Modellierung
Frühere Positionen 1995-1996 Postdoktorand, Department of
Molecular Immunology, Robert Koch-Institute,
Berlin.
1996 Postdoktorand, Department of Molecular
Virology, Hebrew University, Jerusalem, Israel.
1997-1999 Postdoktorand, Institute of
Experimental Immunology, University of Zürich,
Switzerland.
1999-2002 Oberassistent, Institute of Experimental
Immunology, University of Zürich,
Switzerland.
2002-heute Leiter, Institut für Immunbiologie,
Kantonsspital St. Gallen
2009-heute Leiter, Medizinisches
Forschungszentrum, Kantonsspital St. Gallen
Mitgliedschaften Schweizerische Gesellschaft für Allergologie und
Immunologie (SGAI)
Deutsche Gesellschaft für Immunologie (DGfI)
American Association of Immunologists (AAI)
seit 2008 Vorstandsmiglied der Swiss Clinical Trials
Organization (www.scto.org)
2Forschungsprofil
seit 2010 Mitglied des Vorstands der
Schweizerischen Gesellschaft für Allergologie und
Immunologie
Auszeichnungen 1993-1994 NaFöG-Stipendium des Berliner Senats
1996 Golda Meir Postdoctoral Research Fellowship
of the Hebrew University of Jerusalem
1996 Wood-Whelan Research Fellowship of the
International Union of Biochemistry and Molecular
Biology
1997-1999 Postdoktorandenstipendium der
Deutschen Forschungsgemeinschaft
Patente Sahin, U., O. Türeci, und B. Ludewig. Verfahren zur
Identifizierung biologisch aktiver Strukturen
mikrobieller Erreger (MicroGATE). No. 101 08
626.1, February 22, 2001
Weitere Informationen 2002 – 2008 Co-founder and scientific advisor,
Ganymed Pharmaceutical AG, Mainz, Germany
2008 Appointment as Full Professor (W3) for
Experimental Immunology at the Helmholtz Centre
for Infection Research (Braunschweig) and the
Medical School Hannover (declined)
2008 – present Member, executive board of
the Swiss Clinical Trials Organization, the central
cooperation platform for patient-oriented, clinical
research in Switzerland
2010 – present Member and treasurer (since
2014), executive board of Swiss Society of
Allergology and Immunology
2010 Member of the Editorial Board of the
European Journal of Immunology
3Forschungsprofil
2013 Member of the Editorial Board of the
Journal of Immunology
2016 – present Member of Evaluation Panels
“Ambizione&Prima” of the Swiss National Science
Foundation
2016 Member of Evaluation Panel “Infection
and Immunity”, Agence Nationale de la Recherche,
France
4Publikationen
Titel
Wissensch- Alexandre Y O, Schienstock D, Lee H J, Gandolfo L C, Williams C G, Devi
aftlicher S, Pal B, Groom J R, Cao W, Christo S N, Gordon C L, Starkey G, D'Costa
Artikel/ R, Mackay L K, Haque A, Ludewig B, Belz G T, Mueller S N. A diverse
Review fibroblastic stromal cell landscape in the spleen directs tissue
homeostasis and immunity. Sci Immunol 2022; 7:eabj0641.
Rubbert-Roth A, Vuilleumier N, Ludewig B, Schmiedeberg K, Haller C, Von
Kempis J. Anti-SARS-CoV-2 mRNA vaccine in patients with rheumatoid
arthritis. Lancet Rheumatol 2021; 3:e470-e472.
De Martin A, Lütge M, Stanossek Y, Engetschwiler C, Cupovic J, Brown K,
Demmer I, Broglie M A, Geuking M B, Jochum W, McCoy K D, Stöckli S,
Ludewig B. Distinct microbial communities colonize tonsillar squamous
cell carcinoma. Oncoimmunology 2021; 10:1945202.
Vuilleumier N, Pagano S, Ludewig B, Schmiedeberg K, Haller C, Von
Kempis J, Rubbert-Roth A. Anti-SARS-CoV-2 mRNA vaccines as inducers
of humoral response against apolipoprotein A-1?. Eur J Clin Invest 2021;
52:e13713.
Prados A, Onder L, Cheng H W, Mörbe U, Lütge M, Gil Cruz C, Perez
Shibayama C, Koliaraki V, Ludewig B, Kollias G. Fibroblastic reticular cell
lineage convergence in Peyer's patches governs intestinal immunity. Nat
Immunol 2021; 22:510-519.
Pikor N, Cheng H W, Onder L, Ludewig B. Development and
Immunological Function of Lymph Node Stromal Cells. J Immunol 2021;
206:257-263.
Acton S E, Onder L, Novkovic M, Martinez V G, Ludewig B.
Communication, construction, and fluid control: lymphoid organ
fibroblastic reticular cell and conduit networks. Trends Immunol 2021;
42:782-794.
5Publikationen
Titel
Wissensch- Schmiedeberg K, Vuilleumier N, Pagano S, Albrich W, Ludewig B, Von
aftlicher Kempis J, Rubbert-Roth A. Efficacy and tolerability of a third dose of an
Artikel/ mRNA anti-SARS-CoV-2 vaccine in patients with rheumatoid arthritis with
Review absent or minimal serological response to two previous doses. Lancet
Rheumatol 2021; 4:e11-e13.
Berner F, Niederer R, Luimstra J J, Pop O, Jochum A K, Purde M T, Hasan
Ali O, Bomze D, Bauer J, Freudenmann L K, Marcu A, Wolfschmitt E M,
Haen S, Gross T, Dubbelaar M L, Abdou M T, Baumgaertner P, Appenzeller
C, Cicin-Sain C, Lenz T, Speiser D E, Ludewig B, Driessen C, Jörger M,
Früh M, Jochum W, Cozzio A, Rammensee H G, Walz J, Neefjes J, Flatz L.
Keratinocyte differentiation antigen-specific T cells in immune checkpoint
inhibitor-treated NSCLC patients are associated with improved survival.
Oncoimmunology 2021; 10:2006893.
Ring S, Cupovic J, Onder L, Lütge M, Perez Shibayama C, Gil Cruz C,
Scandella E, De Martin A, Mörbe U, Hartmann F, Wenger R, Spiegl M,
Besse A, Bonilla W V, Stemeseder F, Schmidt S, Orlinger K K, Krebs P,
Ludewig B, Flatz L. Viral vector-mediated reprogramming of the
fibroblastic tumor stroma sustains curative melanoma treatment. Nat
Commun 2021; 12:4734.
Seidenberg J, Stellato M, Hukara A, Ludewig B, Klingel K, Distler O,
Błyszczuk P, Kania G. The AP-1 Transcription Factor Fosl-2 Regulates
Autophagy in Cardiac Fibroblasts during Myocardial Fibrogenesis. Int J
Mol Sci 2021; 22:.
Onder L, Cheng H W, Ludewig B. Visualization and functional
characterization of lymphoid organ fibroblasts. Immunol Rev 2021;.
6Publikationen
Titel
Wissensch- Okreglicka K, Iten I, Pohlmeier L, Onder L, Feng Q, Kurrer M, Ludewig B,
aftlicher Nielsen P, Schneider C, Kopf M. PPARγ is essential for the development of
Artikel/ bone marrow erythroblastic island macrophages and splenic red pulp
Review macrophages. J Exp Med 2021; 218:.
Grabherr S, Ludewig B, Pikor N. Insights into coronavirus immunity
taught by the murine coronavirus. Eur J Immunol 2021; 51:1062-1070.
Cupovic J, Ring S, Onder L, Colston J M, Lütge M, Cheng H W, De Martin
A, Provine N M, Flatz L, Oxenius A, Scandella E, Krebs P, Engeler D S,
Klenerman P, Ludewig B. Adenovirus vector vaccination reprograms
pulmonary fibroblastic niches to support protective inflating memory CD8
T cells. Nat Immunol 2021; 22:1042-1051.
Lütge M, Pikor N, Ludewig B. Differentiation and activation of fibroblastic
reticular cells. Immunol Rev 2021; 302:32-46.
Davidson S, Coles M, Thomas T, Kollias G, Ludewig B, Turley S, Brenner
M, Buckley C D. Fibroblasts as immune regulators in infection,
inflammation and cancer. Nat Rev Immunol 2021; 21:704-717.
Bocharov G, Volpert V, Ludewig B, Meyerhans A. Editorial: Mathematical
Modeling of the Immune System in Homeostasis, Infection and Disease.
Front Immunol 2020; 10:2944.
Choi S Y, Bae H, Jeong S H, Park I, Cho H, Hong S P, Lee D H, Lee C K,
Park J S, Suh S H, Choi J, Yang M J, Jang J Y, Onder L, Moon J H, Jeong H
S, Adams R H, Kim J M, Ludewig B, Song J H, Lim D S, Koh G Y. YAP/TAZ
direct commitment and maturation of lymph node fibroblastic reticular
cells. Nat Commun 2020; 11:519.
7Publikationen
Titel
Wissensch- Perkey E, Maurice De Sousa D, Carrington L, Chung J, Dils A, Granadier
aftlicher D, Koch U, Radtke F, Ludewig B, Blazar B R, Siebel C W, Brennan T V,
Artikel/ Nolz J, Labrecque N, Maillard I. GCNT1-Mediated -Glycosylation of the
Review Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated
T Cells. J Immunol 2020; 204:1674-1688.
Chauveau A, Pirgova G, Cheng H W, De Martin A, Zhou F Y, Wideman S,
Rittscher J, Ludewig B, Arnon T I. Visualization of T Cell Migration in the
Spleen Reveals a Network of Perivascular Pathways that Guide Entry into
T Zones. Immunity 2020;.
Novkovic M, Onder L, Bocharov G, Ludewig B. Topological Structure and
Robustness of the Lymph Node Conduit System. Cell Rep 2020;
30:893-904.e6.
Dasoveanu D C, Park H J, Ly C L, Shipman W D, Chyou S, Kumar V,
Tarlinton D, Ludewig B, Mehrara B J, Lu T T. Lymph node stromal CCL2
limits antibody responses. Sci Immunol 2020; 5:.
Guendel F, Kofoed-Branzk M, Gronke K, Tizian C, Witkowski M, Cheng H
W, Heinz G A, Heinrich F, Durek P, Norris P S, Ware C F, Ruedl C, Herold
S, Pfeffer K, Hehlgans T, Waisman A, Becher B, Giannou A D, Brachs S,
Ebert K, Tanriver Y, Ludewig B, Mashreghi M F, Kruglov A A, Diefenbach
A. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-
Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid
Tissues. Immunity 2020; 53:1015-1032.e8.
Ring S, Krolik M, Hartmann F, Schmidt E, Ali O H, Ludewig B, Kochanek
S, Flatz L. Heterologous Prime Boost Vaccination Induces Protective
Melanoma-Specific CD8 T Cell Responses. Mol Ther Oncolytics 2020;
19:179-187.
8Publikationen
Titel
Wissensch- Pikor N, Morbe U, Lütge M, Gil Cruz C, Perez Shibayama C, Novkovic M,
aftlicher Cheng H W, Nombela-Arrieta C, Nagasawa T, Linterman M A, Onder L,
Artikel/ Ludewig B. Remodeling of light and dark zone follicular dendritic cells
Review governs germinal center responses. Nat Immunol 2020; 21:649-659.
Aparicio-Domingo P, Cannelle H, Buechler M B, Nguyen S, Kallert S M,
Favre S, Alouche N, Papazian N, Ludewig B, Cupedo T, Pinschewer D D,
Turley S J, Luther S A. Fibroblast-derived IL-33 is dispensable for lymph
node homeostasis but critical for CD8 T-cell responses to acute and
chronic viral infection. Eur J Immunol 2020;.
Bocharov G, Casella V, Argilaguet J, Grebennikov D, Güerri-Fernandez R,
Ludewig B, Meyerhans A. Numbers Game and Immune Geography as
Determinants of Coronavirus Pathogenicity. Front Cell Infect Microbiol
2020; 10:559209.
Perez Shibayama C, Islander U, Lütge M, Cheng H W, Onder L, Ring S, De
Martin A, Novkovic M, Colston J, Gil Cruz C, Ludewig B. Type I interferon
signaling in fibroblastic reticular cells prevents exhaustive activation of
antiviral CD8 T cells. Sci Immunol 2020; 5:.
Cosgrove J, Novkovic M, Albrecht S, Pikor N, Zhou Z, Onder L, Mörbe U,
Cupovic J, Miller H, Alden K, Thuery A, O'Toole P, Pinter R, Jarrett S,
Taylor E, Venetz D, Heller M, Uguccioni M, Legler D F, Lacey C J,
Coatesworth A, Polak W G, Cupedo T, Manoury B, Thelen M, Stein J V,
Wolf M, Leake M C, Timmis J, Ludewig B, Coles M C. B cell zone reticular
cell microenvironments shape CXCL13 gradient formation. Nat Commun
2020; 11:3677.
Ludewig B. Rolf Zinkernagel and the co-discovery of MHC restriction
together with Peter Doherty. Allergy 2019;.
9Publikationen
Titel
Wissensch- Camara A, Cordeiro O G, Alloush F, Sponsel J, Chypre M, Onder L, Asano
aftlicher K, Tanaka M, Yagita H, Ludewig B, Flacher V, Mueller C G. Lymph Node
Artikel/ Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-
Review RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.
Immunity 2019; 50:1467-1481.e6.
Colston J M, Hutchings C, Chinnakannan S, Highton A, Perez Shibayama
C, Ludewig B, Klenerman P. Divergent memory responses driven by
adenoviral vectors are impacted by epitope competition. Eur J Immunol
2019;.
Solmaz G, Puttur F, Francozo M, Lindenberg M, Guderian M, Swallow M,
Duhan V, Khairnar V, Kalinke U, Ludewig B, Clausen B E, Wagner H, Lang
K S, Sparwasser T D. TLR7 Controls VSV Replication in CD169 SCS
Macrophages and Associated Viral Neuroinvasion. Front Immunol 2019;
10:466.
Fässler M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S,
Niederer R, Gil Cruz C, Perez Shibayama C, Krolik M, Siano M, Joerger M,
Recher M, Risch L, Guesewell S, Risch M, Speiser D E, Ludewig B,
Levesque M P, Dummer R, Flatz L. Antibodies as biomarker candidates for
response and survival to checkpoint inhibitors in melanoma patients. J
Immunother Cancer 2019; 7:50.
Argilaguet J, Pedragosa M, Esteve-Codina A, Riera G, Vidal E, Gil Cruz C,
Casella V, Andreu D, Kaisho T, Bocharov G, Ludewig B, Heath S,
Meyerhans A. Systems analysis reveals complex biological processes
during virus infection fate decisions. Genome Res 2019; 29:907-919.
Perez Shibayama C, Gil Cruz C, Ludewig B. Fibroblastic reticular cells at
the nexus of innate and adaptive immune responses. Immunol Rev 2019;
289:31-41.
10Publikationen
Titel
Wissensch- Cheng H W, Onder L, Novkovic M, Soneson C, Lütge M, Pikor N, Scandella
aftlicher E, Robinson M D, Miyazaki J I, Tersteegen A, Sorg U, Pfeffer K, Rülicke T,
Artikel/ Hehlgans T, Ludewig B. Origin and differentiation trajectories of
Review fibroblastic reticular cells in the splenic white pulp. Nat Commun 2019;
10:1739.
Denton A E, Innocentin S, Carr E J, Bradford B M, Lafouresse F, Mabbott
N A, Mörbe U, Ludewig B, Groom J R, Good-Jacobson K L, Linterman M A.
Type I interferon induces CXCL13 to support ectopic germinal center
formation. J Exp Med 2019;.
Lercher A, Bhattacharya A, Popa A M, Caldera M, Schlapansky M F,
Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner J S, Vitko D,
Pinter T, Genger J W, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke
U, Ludewig B, Moriggl R, Bennett K L, Menche J, Cheng P N, Schabbauer
G, Trauner M, Klavins K, Bergthaler A. Type I Interferon Signaling
Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to
Suppress T Cell Function. Immunity 2019; 51:1074-1087.e9.
11Publikationen
Titel
Wissensch- Cossarizza A, Chang H D, Radbruch A, Acs A, Adam D, Adam-Klages S,
aftlicher Agace W W, Aghaeepour N, Akdis M, Allez M, Almeida L N, Alvisi G,
Artikel/ Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari C T, Bari
Review S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S,
Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W,
Benes V, Beyaert R, Blanco A, Boardman D A, Bogdan C, Borger J G,
Borsellino G, Boulais P E, Bradford J A, Brenner D, Brinkman R R, Brooks
A E S, Busch D H, Büscher M, Bushnell T P, Calzetti F, Cameron G,
Cammarata I, Cao X, Cardell S L, Casola S, Cassatella M A, Cavani A,
Celada A, Chatenoud L, Chattopadhyay P K, Chow S, Christakou E, Čičin-
Šain L, Clerici M, Colombo F S, Cook L, Cooke A, Cooper A M, Corbett A J,
Cosma A, Cosmi L, Coulie P G, Cumano A, Cvetkovic L, Dang V D, Dang-
Heine C, Davey M S, Davies D, De Biasi S, Del Zotto G, Dela Cruz G V,
Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo J P,
Diefenbach A, Dieli F, Dolf A, Dörner T, Dress R J, Dudziak D, Dustin M,
Dutertre C A, Ebner F, Eckle S B G, Edinger M, Eede P, Ehrhardt G R A,
Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk
C S, Fehniger T A, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor
K, Fillatreau S, Follo M, Förster I, Foster J, Foulds G A, Frehse B, Frenette
P S, Frischbutter S, Fritzsche W, Galbraith D W, Gangaev A, Garbi N,
Gaudilliere B, Gazzinelli R T, Geginat J, Gerner W, Gherardin N A,
Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey D I, Goettlinger C,
González-Navajas J M, Goodyear C S, Gori A, Grogan J L, Grummitt D,
Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann
L, Hansson G, Harpur C M, Hartmann S, Hauser A, Hauser A E, Haviland
D L, Hedley D, Hernández D C, Herrera G, Herrmann M, Hess C, Höfer T,
Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P,
Houston J P, Hoyer B F, Huang B, Huang F P, Huber J E, Huehn J,
Hundemer M, Hunter C A, Hwang W Y K, Iannone A, Ingelfinger F, Ivison
S M, Jäck H M, Jani P K, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T,
12Publikationen
Titel
Wissensch- Dubey L K, Ludewig B, Luther S A, Harris N L. IL-4Rα-Expressing B Cells
aftlicher Are Required for CXCL13 Production by Fibroblastic Reticular Cells. Cell
Artikel/ Rep 2019; 27:2442-2458.e5.
Review Li C, Lam E, Perez Shibayama C, Ward L A, Zhang J, Lee D, Nguyen A,
Ahmed M, Brownlie E, Korneev K V, Rojas O, Sun T, Navarre W, He H H,
Liao S, Martin A, Ludewig B, Gommerman J L. Early-life programming of
mesenteric lymph node stromal cell identity by the lymphotoxin pathway
regulates adult mucosal immunity. Sci Immunol 2019; 4:.
Brenig R, Pop O, Triantafyllou E, Geng A, Singanayagam A, Perez
Shibayama C, Besse L, Cupovic J, Künzler-Heule P, Boldanova T, Brand S,
Semela D, Duong F H, Weston C J, Ludewig B, Heim M H, Wendon J,
Antoniades C G, Bernsmeier C. Expression of AXL receptor tyrosine
kinase relates to monocyte dysfunction and severity of cirrhosis. Life Sci
Alliance 2019; 3:.
Zarak-Crnkovic M, Kania G, Jaźwa-Kusior A, Czepiel M, Wijnen W J, Czyż
J, Müller-Edenborn B, Vdovenko D, Lindner D, Gil Cruz C, Bachmann M,
Westermann D, Ludewig B, Distler O, Lüscher T F, Klingel K, Eriksson U,
Błyszczuk P. Heart non-specific effector CD4 T cells protect from
postinflammatory fibrosis and cardiac dysfunction in experimental
autoimmune myocarditis. Basic Res Cardiol 2019; 115:6.
Gil Cruz C, Perez Shibayama C, De Martin A, Ronchi F, Van Der Borght K,
Niederer R, Onder L, Lütge M, Novkovic M, Nindl V, Ramos G, Arnoldini M,
Slack E M C, Boivin-Jahns V, Jahns R, Wyss M, Mooser C, Lambrecht B N,
Maeder M T, Rickli H, Flatz L, Eriksson U, Geuking M B, McCoy K D,
Ludewig B. Microbiota-derived peptide mimics drive lethal inflammatory
cardiomyopathy. Science 2019; 366:881-886.
13Publikationen
Titel
Wissensch- Rieckmann M, Delgobo M, Gaal C, Büchner L, Steinau P, Reshef D, Gil
aftlicher Cruz C, Ter Horst E N, Kircher M, Reiter T, Heinze K G, Niessen H W,
Artikel/ Krijnen P A, Van Der Laan A M, Piek J J, Koch C, Wester H J, Lapa C,
Review Bauer W R, Ludewig B, Friedman N, Frantz S, Hofmann U, Ramos G C.
Myocardial infarction triggers cardioprotective antigen-specific T helper
cell responses. J Clin Invest 2019; 130:.
Baumann N S, Torti N, Welten S P M, Barnstorf I, Borsa M, Pallmer K,
Oduro J D, Cicin-Sain L, Ikuta K, Ludewig B, Oxenius A. Tissue
maintenance of CMV-specific inflationary memory T cells by IL-15. PLoS
Pathog 2018; 14:e1006993.
Perez Shibayama C, Gil Cruz C, Cheng H W, Onder L, Printz A, Morbe U,
Novkovic M, Li C, Lopez-Macias C, Buechler M B, Turley S J, Mack M,
Soneson C, Robinson M D, Scandella E, Gommerman J, Ludewig B.
Fibroblastic reticular cells initiate immune responses in visceral adipose
tissues and secure peritoneal immunity. Sci Immunol 2018; 3:.
Emgård J, Kammoun H, García-Cassani B, Chesné J, Parigi S M, Jacob J
M, Cheng H W, Evren E, Das S, Czarnewski P, Sleiers N, Melo-Gonzalez F,
Kvedaraite E, Svensson M, Scandella E, Hepworth M R, Huber S, Ludewig
B, Peduto L, Villablanca E J, Veiga-Fernandes H, Pereira J P, Flavell R A,
Willinger T. Oxysterol Sensing through the Receptor GPR183 Promotes
the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and
Colonic Inflammation. Immunity 2018; 48:120-132.e8.
Cheng H W, Onder L, Cupovic J, Bösch M, Novkovic M, Pikor N, Tarantino
I, Rodriguez R, Schneider T, Jochum W, Brutsche M, Ludewig B. CCL19-
producing fibroblastic stromal cells restrain lung carcinoma growth by
promoting local antitumor T-cell responses. J Allergy Clin Immunol 2018;.
14Publikationen
Titel
Wissensch- Takeuchi A, Ozawa M, Kanda Y, Kozai M, Ohigashi I, Kurosawa Y, Rahman
aftlicher M A, Kawamura T, Shichida Y, Umemoto E, Miyasaka M, Ludewig B,
Artikel/ Takahama Y, Nagasawa T, Katakai T. A Distinct Subset of Fibroblastic
Review Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment
of the Lymph Node. Front Immunol 2018; 9:2196.
Van Der Borght K, Scott C L, Martens L, Sichien D, Van Isterdael G, Nindl
V, Saeys Y, Boon L, Ludewig B, Gillebert T C, Lambrecht B N. Myocarditis
Elicits Dendritic Cell and Monocyte Infiltration in the Heart and Self-
Antigen Presentation by Conventional Type 2 Dendritic Cells. Front
Immunol 2018; 9:2714.
Onder L, Ludewig B. A Fresh View on Lymph Node Organogenesis. Trends
Immunol 2018; 39:775-787.
Bösch M, Onder L, Cheng H W, Novkovic M, Morbe U, Sopper S, Gastl G,
Jochum W, Ruhstaller T, Knauer M, Ludewig B. Interleukin 7-expressing
fibroblasts promote breast cancer growth through sustenance of tumor
cell stemness. Oncoimmunology 2018; 7:e1414129.
Bogdanova D, Takeuchi A, Ozawa M, Kanda Y, Rahman M A, Ludewig B,
Kinashi T, Katakai T. Essential Role of Canonical NF-κB Activity in the
Development of Stromal Cell Subsets in Secondary Lymphoid Organs. J
Immunol 2018; 201:3580-3586.
Onder L, Ludewig B. Redefining the Nature of Lymphoid Tissue Organizer
Cells: Response to 'Complexity of Lymphoid Tissue Organizers' by Koning
and Mebius. Trends Immunol 2018; 39:952-953.
Novkovic M, Onder L, Cheng H W, Bocharov G, Ludewig B. Integrative
Computational Modeling of the Lymph Node Stromal Cell Landscape.
Front Immunol 2018; 9:2428.
15Publikationen
Titel
Wissensch- Carreño J M, Perez Shibayama C, Gil Cruz C, López-Macías C, Vernazza P,
aftlicher Ludewig B, Albrich W. Evolution of Salmonella Typhi outer membrane
Artikel/ protein-specific T and B cell responses in humans following oral Ty21a
Review vaccination: A randomized clinical trial. PLoS ONE 2017; 12:e0178669.
Dubey L K, Karempudi P, Luther S A, Ludewig B, Harris N L. Interactions
between fibroblastic reticular cells and B cells promote mesenteric lymph
node lymphangiogenesis. Nat Commun 2017; 8:367.
Onder L, Morbe U, Pikor N, Novkovic M, Cheng H W, Hehlgans T, Pfeffer
K, Becher B, Waisman A, Rülicke T, Gommerman J, Mueller C G, Sawa S,
Scandella E, Ludewig B. Lymphatic Endothelial Cells Control Initiation of
Lymph Node Organogenesis. Immunity 2017; 47:80-92.e4.
Van Der Borght K, Scott C L, Nindl V, Bouché A, Martens L, Sichien D,
Van Moorleghem J, Vanheerswynghels M, De Prijck S, Saeys Y, Ludewig
B, Gillebert T, Guilliams M, Carmeliet P, Lambrecht B N. Myocardial
Infarction Primes Autoreactive T Cells through Activation of Dendritic
Cells. Cell Rep 2017; 18:3005-3017.
16Publikationen
Titel
Wissensch- Cossarizza A, Chang H D, Radbruch A, Andrä I, Annunziato F, Bacher P,
aftlicher Barnaba V, Battistini L, Bauer W M, Baumgart S, Becher B, Beisker W,
Artikel/ Berek C, Blanco A, Borsellino G, Boulais P E, Brinkman R R, Büscher M,
Review Busch D H, Bushnell T P, Cao X, Cavani A, Chattopadhyay P K, Cheng Q,
Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang V D,
Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G,
Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg V S,
Dörner T, Ehrhardt G R A, Endl E, Engel P, Engelhardt B, Esser C, Everts
B, Falk C S, Fehniger T A, Filby A, Fillatreau S, Follo M, Förster I, Foster J,
Foulds G A, Frenette P S, Galbraith D, Garbi N, García-Godoy M D,
Ghoreschi K, Gibellini L, Goettlinger C, Goodyear C S, Gori A, Grogan J,
Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser A E,
Haviland D L, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T,
Hombrink P, Houston J P, Hoyer B F, Huang B, Hunter C A, Iannone A,
Jäck H M, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller
B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P,
Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold M D,
Levings M K, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke
A, Lubberts E, Ludewig B, Lugli E, Maecker H T, Martrus G, Matarese G,
Maueröder C, McGrath M, McInnes I, Mei H E, Melchers F, Melzer S,
Mielenz D, Mills K, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L,
Mosmann T R, Müller S, Müller W, Münz C, Multhoff G, Munoz L E, Murphy
K M, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor J
E, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J,
Philips D, Pickl W, Piconese S, Pinti M, Pockley A G, Podolska M J, Pucillo
C, Quataert S A, Radstake T R D J, Rajwa B, Rebhahn J A, Recktenwald
D, Remmerswaal E B M, Rezvani K, Rico L G, Robinson J P, Romagnani C,
Rubartelli A, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y,
Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F,
Schimisky E, Schmid S A, Schmitt S, Schober K, Schüler T, Schulz A R,
17Publikationen
Titel
Wissensch- Novkovic M, Onder L, Bocharov G, Ludewig B. Graph Theory-Based
aftlicher Analysis of the Lymph Node Fibroblastic Reticular Cell Network. Methods
Artikel/ Mol Biol 2017; 1591:43-57.
Review Pikor N, Cupovic J, Onder L, Gommerman J L, Ludewig B. Stromal Cell
Niches in the Inflamed Central Nervous System. J Immunol 2017;
198:1775-1781.
Kindler E, Gil Cruz C, Spanier J, Li Y, Wilhelm J, Rabouw H H, Züst R,
Hwang M, V'kovski P, Stalder H, Marti S, Habjan M, Cervantes-Barragan
L, Elliot R, Karl N, Gaughan C, Van Kuppeveld F J M, Silverman R H,
Keller M, Ludewig B, Bergmann C C, Ziebuhr J, Weiss S R, Kalinke U,
Thiel V. Early endonuclease-mediated evasion of RNA sensing ensures
efficient coronavirus replication. PLoS Pathog 2017; 13:e1006195.
Chung J, Ebens C L, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A,
Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran I T, Chai Q, Onder
L, Yan M, Reddy P, Blazar B R, Huang A Y, Brennan T V, Bishop D K,
Ludewig B, Siebel C W, Radtke F, Luther S A, Maillard I. Fibroblastic
niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin
Invest 2017; 127:1574-1588.
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K,
Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig
B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka
M, Umemoto E. Fibroblastic reticular cell-derived lysophosphatidic acid
regulates confined intranodal T-cell motility. Elife 2016; 5:.
Cupovic J, Onder L, Gil Cruz C, Weiler E, Caviezel-Firner S, Perez
Shibayama C, Rülicke T, Bechmann I, Ludewig B. Central Nervous System
Stromal Cells Control Local CD8(+) T Cell Responses during Virus-
Induced Neuroinflammation. Immunity 2016; 44:622-33.
18Publikationen
Titel
Wissensch- Cordeiro O G, Chypre M, Brouard N, Rauber S, Alloush F, Romera-
aftlicher Hernandez M, Bénézech C, Li Z, Eckly A, Coles M C, Rot A, Yagita H, Léon
Artikel/ C, Ludewig B, Cupedo T, Lanza F, Mueller C G. Integrin-Alpha IIb
Review Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to
RANKL. PLoS ONE 2016; 11:e0151848.
Novkovic M, Onder L, Cupovic J, Abe J, Bomze D, Cremasco V, Scandella
E, Stein J V, Bocharov G, Turley S J, Ludewig B. Topological Small-World
Organization of the Fibroblastic Reticular Cell Network Determines Lymph
Node Functionality. PLoS Biol 2016; 14:e1002515.
Dubey L K, Lebon L, Mosconi I, Yang C Y, Scandella E, Ludewig B, Luther
S A, Harris N L. Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes
De Novo Follicle Formation and Antibody Production following Intestinal
Helminth Infection. Cell Rep 2016; 15:1527-41.
Bösch M, Sopper S, Zeimet A G, Reimer D, Gastl G, Ludewig B, Wolf D.
Heterogeneity of Cancer Stem Cells: Rationale for Targeting the Stem
Cell Niche. Biochim Biophys Acta 2016; 1866:276-289.
Gil Cruz C, Perez Shibayama C, Onder L, Chai Q, Cupovic J, Cheng H W,
Novkovic M, Lang P A, Geuking M B, McCoy K D, Abe S, Cui G, Ikuta K,
Scandella E, Ludewig B. Fibroblastic reticular cells regulate intestinal
inflammation via IL-15-mediated control of group 1 ILCs. Nat Immunol
2016; 17:1388-1396.
Carreño J M, Perez Shibayama C, Gil Cruz C, Printz A, Pastelin R, Isibasi
A, Chariatte D, Tanoue Y, López-Macías C, Gander B, Ludewig B. PLGA-
microencapsulation protects Salmonella typhi outer membrane proteins
from acidic degradation and increases their mucosal immunogenicity.
Vaccine 2016; 34:4263-9.
Onder L, Ludewig B. Another TLO in the Wall: Education and Control of T
Cells in Atherosclerotic Arteries. Immunity 2015; 42:981-3.
19Publikationen
Titel
Wissensch- Perez Shibayama C, Ludewig B. Tuning up FALCs: immunological
aftlicher shielding in the body cavities. Nat Immunol 2015; 16:796-8.
Artikel/ Onder L, Nindl V, Scandella E, Chai Q, Cheng H W, Caviezel-Firner S,
Review Novkovic M, Bomze D, Maier R, Mair F, Ledermann B, Becher B, Waisman
A, Ludewig B. Alternative NF-κB signaling regulates mTEC differentiation
from podoplanin-expressing presursors in the cortico-medullary junction.
Eur J Immunol 2015;.
Mair F, Joller S, Hoeppli R, Onder L, Hahn M, Ludewig B, Waisman A,
Becher B. The NFκB-inducing kinase is essential for the developmental
programming of skin-resident and IL-17-producing γδ T cells. Elife 2015;
4:.
Bhattacharya A, Hegazy A N, Deigendesch N, Kosack L, Cupovic J,
Kandasamy R K, Hildebrandt A, Merkler D, Kühl A A, Vilagos B, Schliehe
C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu H C, Lang P A,
Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M,
Bergthaler A. Superoxide Dismutase 1 Protects Hepatocytes from Type I
Interferon-Driven Oxidative Damage. Immunity 2015; 43:974-86.
Rodda L B, Bannard O, Ludewig B, Nagasawa T, Cyster J G. Phenotypic
and Morphological Properties of Germinal Center Dark Zone Cxcl12-
Expressing Reticular Cells. J Immunol 2015; 195:4781-91.
Tschismarov R, Firner S, Gil Cruz C, Göschl L, Boucheron N, Steiner G,
Matthias P, Seiser C, Ludewig B, Ellmeier W. HDAC1 controls CD8+ T cell
homeostasis and antiviral response. PLoS ONE 2014; 9:e110576.
Astarita J L, Cremasco V, Fu J, Darnell M C, Peck J R, Nieves-Bonilla J M,
Song K, Kondo Y, Woodruff M C, Gogineni A, Onder L, Ludewig B, Weimer
R M, Carroll M C, Mooney D J, Xia L, Turley S J. The CLEC-2-podoplanin
axis controls the contractility of fibroblastic reticular cells and lymph node
microarchitecture. Nat Immunol 2014; 16:75-84.
20Publikationen
Titel
Wissensch- Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B,
aftlicher Stein J V. Thromboxane A2 acts as tonic immunoregulator by preferential
Artikel/ disruption of low-avidity CD4+ T cell-dendritic cell interactions. J Exp Med
Review 2014; 211:2507-17.
Fasnacht N, Huang H Y, Koch U, Favre S, Auderset F, Chai Q, Onder L,
Kallert S, Pinschewer D D, MacDonald H R, Tacchini-Cottier F, Ludewig B,
Luther S A, Radtke F. Specific fibroblastic niches in secondary lymphoid
organs orchestrate distinct Notch-regulated immune responses. J Exp
Med 2014; 211:2265-79.
Sage A P, Murphy D, Maffia P, Masters L M, Sabir S R, Baker L L,
Cambrook H, Finigan A J, Ait-Oufella H, Grassia G, Harrison J E, Ludewig
B, Reith W, Hansson G K, Reizis B, Hugues S, Mallat Z. MHC Class II-
restricted antigen presentation by plasmacytoid dendritic cells drives
proatherogenic T cell immunity. Circulation 2014; 130:1363-73.
Perez Shibayama C, Gil Cruz C, Pastelin-Palacios R, Cervantes-Barragan
L, Hisaki E, Chai Q, Onder L, Scandella E, Regen T, Waisman A, Isibasi A,
López-Macías C, Ludewig B. IFN-γ-producing CD4+ T cells promote
generation of protective germinal center-derived IgM+ B cell memory
against Salmonella Typhi. J Immunol 2014; 192:5192-200.
Perez Shibayama C, Gil Cruz C, Ludewig B. Plasticity and complexity of B
cell responses against persisting pathogens. Immunol Lett 2014;
162:53-8.
Cremasco V, Woodruff M C, Onder L, Cupovic J, Nieves-Bonilla J M,
Schildberg F A, Chang J, Cremasco F, Harvey C J, Wucherpfennig K,
Ludewig B, Carroll M C, Turley S J. B cell homeostasis and follicle confines
are governed by fibroblastic reticular cells. Nat Immunol 2014;
15:973-81.
21Publikationen
Titel
Wissensch- Bocharov G, Luzyanina T, Cupovic J, Ludewig B. Asymmetry of Cell
aftlicher Division in CFSE-Based Lymphocyte Proliferation Analysis. Front Immunol
Artikel/ 2013; 4:264.
Review Perez Shibayama C, Gil Cruz C, Nussbacher M, Allgäuer E, Cervantes-
Barragan L, Züst R, Ludewig B. Dendritic cell-specific delivery of Flt3L by
coronavirus vectors secures induction of therapeutic antitumor immunity.
PLoS ONE 2013; 8:e81442.
Coelho F M, Natale D, Soriano S F, Hons M, Swoger J, Mayer J, Danuser
R, Scandella E, Pieczyk M, Zerwes H G, Junt T, Sailer A W, Ludewig B,
Sharpe J, Figge M T, Stein J V. Naive B-cell trafficking is shaped by local
chemokine availability and LFA-1-independent stromal interactions. Blood
2013; 121:4101-9.
Chai Q, Onder L, Scandella E, Gil Cruz C, Perez Shibayama C, Cupovic J,
Danuser R, Sparwasser T, Luther S A, Thiel V, Rülicke T, Stein J V,
Hehlgans T, Ludewig B. Maturation of lymph node fibroblastic reticular
cells from myofibroblastic precursors is critical for antiviral immunity.
Immunity 2013; 38:1013-24.
Caviezel-Firner S, Engeler D S, Bolinger B, Onder L, Scandella E, Yu M,
Kroczek R A, Ludewig B. Systemic minor histocompatibility antigen
expression in blood endothelial cells prevents T cell-mediated vascular
immunopathology. Eur J Immunol 2013; 43:3233-43.
Iolyeva M, Aebischer D, Proulx S T, Willrodt A H, Ecoiffier T, Häner S,
Bouchaud G, Krieg C, Onder L, Ludewig B, Santambrogio L, Boyman O,
Chen L, Finke D, Halin C. Interleukin-7 is produced by afferent lymphatic
vessels and supports lymphatic drainage. Blood 2013; 122:2271-81.
22Publikationen
Titel
Wissensch- Bolinger B, Sims S, O'Hara G, De Lara C, Tchilian E, Firner S, Engeler D
aftlicher S, Ludewig B, Klenerman P. A new model for CD8+ T cell memory
Artikel/ inflation based upon a recombinant adenoviral vector. J Immunol 2013;
Review 190:4162-74.
Luzyanina T, Cupovic J, Ludewig B, Bocharov G. Mathematical models for
CFSE labelled lymphocyte dynamics: asymmetry and time-lag in division.
J Math Biol 2013;.
Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, Stein J V,
Ludewig B. Endothelial cell-specific lymphotoxin-β receptor signaling is
critical for lymph node and high endothelial venule formation. J Exp Med
2013; 210:465-73.
Mueller R, Maier R, Hoschler K, Zambon M, Ludewig B, Herrmann M,
Schulze-Koops H, Von Kempis J. Efficient boosting of the antiviral T cell
response in B cell-depleted patients with autoimmune rheumatic diseases
following influenza vaccination. Clin Exp Rheumatol 2013; 31:723-30.
Onder L, Nindl V, Ludewig B. Tight control - decision-making during T
cell-vascular endothelial cell interaction. Front Immunol 2012; 3:279.
Nindl V, Maier R, Ratering D, Degiuli R, Züst R, Thiel V, Scandella E, Di
Padova F, Kopf M, Rudin M, Rülicke T, Ludewig B. Cooperation of Th1 and
Th17 cells determines transition from autoimmune myocarditis to dilated
cardiomyopathy. Eur J Immunol 2012; 42:2311-21.
Cervantes-Barragan L, Bechmann I, Waisman A, Lahl K, Sparwasser T,
Thiel V, Ludewig B. Regulatory T cells selectively preserve immune
privilege of self-antigens during viral central nervous system infection. J
Immunol 2012; 188:3678-85.
23Publikationen
Titel
Wissensch- Weber S S, Joller N, Küntzel A B, Spörri R, Tchang V S, Scandella E, Rösli
aftlicher C, Ludewig B, Hilbi H, Oxenius A. Identification of protective B cell
Artikel/ antigens of Legionella pneumophila. J Immunol 2012; 189:841-9.
Review Ludewig B, Stein J V, Sharpe J, Cervantes L, Thiel V, Bocharov G. A global
"imaging'' view on systems approaches in immunology. Eur J Immunol
2012; 42:3116-25.
Onder L, Narang P, Scandella E, Chai Q, Iolyeva M, Hoorweg K, Halin C,
Richie E, Kaye P, Westermann J, Cupedo T, Coles M, Ludewig B. IL-7-
producing stromal cells are critical for lymph node remodeling. Blood
2012; 120:4675-83.
Engeler D S, Scandella E, Ludewig B, Schmid H P. Ciprofloxacin and
epirubicin synergistically induce apoptosis in human urothelial cancer cell
lines. Urol Int 2012; 88:343-9.
Cervantes L, Lewis K L, Thiel V, Hugues S, Reith W, Ludewig B, Reizis B.
Plasmacytoid dendritic cells control T-cell response to chronic viral
infection. Proc Natl Acad Sci USA 2012; 109:3012-7.
Frebel H, Nindl V, Schuepbach R A, Braunschweiler T, Richter K, Vogel J,
Wagner C A, Loffing-Cueni D, Kurrer M, Ludewig B, Oxenius A.
Programmed death 1 protects from fatal circulatory failure during
systemic virus infection of mice. J Exp Med 2012; 209:2485-99.
Gil Cruz C, Perez Shibayama C, Waisman A, Bechmann I, Thiel V,
Cervantes L, Ludewig B. T helper cell- and CD40-dependent germline IgM
prevents chronic virus-induced demyelinating disease. Proc Natl Acad Sci
USA 2012; 109:1233-8.
24Publikationen
Titel
Wissensch- Zuest R, Cervantes L, Habjan M, Maier R, Neuman B W, Ziebuhr J,
aftlicher Szretter K J, Baker S C, Barchet W, Diamond M S, Siddell S G, Ludewig B,
Artikel/ Thiel V. Ribose 2'-O-methylation provides a molecular signature for the
Review distinction of self and non-self mRNA dependent on the RNA sensor
Mda5. Nat Immunol 2011; 12:137-43.
Pastelin-Palacios R, Gil Cruz C, Perez Shibayama C, Moreno-Eutimio M A,
Cervantes L, Arriaga-Pizano L, Ludewig B, Cunningham A F, García-
Zepeda E A, Becker I, Alpuche-Aranda C, Bonifaz L, Gunn J S, Isibasi A,
López-Macías C. Subversion of innate and adaptive immune activation
induced by structurally modified lipopolysaccharide from Salmonella
typhimurium. Immunology 2011; 133:469-81.
Onder L, Scandella E, Chai Q, Mayer C T, Sparwasser T, Thiel V, Rülicke T,
Ludewig B. A novel bacterial artificial chromosome-transgenic
podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front
Immunol 2011; 2:50.
Bocharov G A, Danilov A A, Vassilevski Y V, Marchuk G I, Chereshnev V A,
Ludewig B. Simulation of the interferon-mediated protective field in
lymphoid organs with their spatial and functional organization taken into
consideration. Dokl Biol Sci 2011; 439:194-6.
Ludewig B, Cervantes L. CD169(+) macrophages take the bullet. Nat
Immunol 2011; 13:13-4.
Kumar V, Scandella E, Danuser R, Onder L, Nitschké M, Fukui Y, Halin C,
Ludewig B, Stein J V. Global lymphoid tissue remodeling during a viral
infection is orchestrated by a B cell-lymphotoxin-dependent pathway.
Blood 2010; 115:4725-33.
25Publikationen
Titel
Wissensch- Lang P A, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C,
aftlicher Meryk A, Kulawik A, Cervantes L, Van Rooijen N, Kalinke U, Ludewig B,
Artikel/ Hengartner H, Harris N, Häussinger D, Ohashi P S, Zinkernagel R M, Lang
Review K S. Tissue macrophages suppress viral replication and prevent severe
immunopathology in an interferon-I-dependent manner in mice.
Hepatology 2010; 52:25-32.
Schwendener R A, Ludewig B, Cerny A, Engler O. Liposome-based
vaccines. Methods in molecular biology (Clifton, N.J.) 2010; 605:163-75.
Bocharov G, Zuest R, Cervantes L, Luzyanina T, Chiglintsev E,
Chereshnev V A, Thiel V, Ludewig B. A systems immunology approach to
plasmacytoid dendritic cell function in cytopathic virus infections. PLoS
Pathog 2010; 6:e1001017.
Cervantes L, Zuest R, Maier R, Sierro S, Janda J, Levy F, Speiser D,
Romero P, Rohrlich P S, Ludewig B, Thiel V. Dendritic cell-specific antigen
delivery by coronavirus vaccine vectors induces long-lasting protective
antiviral and antitumor immunity. MBio 2010; 1:.
Bolinger B, Engeler D S, Krebs P, Miller S, Hoffmann M, Palmer D C,
Restifo N P, Tian Y, Clavien P A, Ludewig B. IFN-gamma-receptor
signaling ameliorates transplant vasculopathy through attenuation of
CD8+ T-cell-mediated injury of vascular endothelial cells. Eur J Immunol
2010; 40:733-43.
Zinkernagel M S, Bolinger B, Krebs P, Onder L, Miller S, Ludewig B.
Immunopathological basis of lymphocytic choriomeningitis virus-induced
chorioretinitis and keratitis. Journal of virology 2009; 83:159-66.
26Publikationen
Titel
Wissensch- Lang P A, Cervantes L, Verschoor A, Navarini A A, Recher M, Pellegrini M,
aftlicher Flatz L, Bergthaler A, Honda K, Ludewig B, Ohashi P S, Lang K S.
Artikel/ Hematopoietic cell-derived interferon controls viral replication and virus-
Review induced disease. Blood 2009; 113:1045-52.
Cervantes L, Kalinke U, Zuest R, König M, Reizis B, López-Macías C, Thiel
V, Ludewig B. Type I IFN-mediated protection of macrophages and
dendritic cells secures control of murine coronavirus infection. Journal of
immunology (Baltimore, Md. : 1950) 2009; 182:1099-106.
Engeler D S, Ludewig B, Schmid H P. [Uro-oncological research from the
laboratory and clinical practice]. Der Urologe. Ausg. A 2008; 47:978-81.
Lang P A, Contaldo C, Georgiev P, El-Badry A M, Recher M, Kurrer M,
Cervantes L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B,
Bader M, Graf R, Clavien P A, Hegazy A N, Löhning M, Harris N L, Ohashi
P S, Hengartner H, Zinkernagel R M, Lang K S. Aggravation of viral
hepatitis by platelet-derived serotonin. Nature medicine 2008;
14:756-61.
Junt T, Scandella E, Ludewig B. Form follows function: lymphoid tissue
microarchitecture in antimicrobial immune defence. Nature reviews.
Immunology 2008; 8:764-75.
Kang T B, Oh G S, Scandella E, Bolinger B, Ludewig B, Kovalenko A,
Wallach D. Mutation of a self-processing site in caspase-8 compromises
its apoptotic but not its nonapoptotic functions in bacterial artificial
chromosome-transgenic mice. Journal of immunology (Baltimore, Md. :
1950) 2008; 181:2522-32.
27Publikationen
Titel
Wissensch- Birnberg T, Bar-On L, Sapoznikov A, Caton M L, Cervantes L, Makia D,
aftlicher Krauthgamer R, Brenner O, Ludewig B, Brockschnieder D, Riethmacher
Artikel/ D, Reizis B, Jung S. Lack of conventional dendritic cells is compatible with
Review normal development and T cell homeostasis, but causes myeloid
proliferative syndrome. Immunity 2008; 29:986-97.
Eriksson K K, Cervantes L, Ludewig B, Thiel V. Mouse hepatitis virus liver
pathology is dependent on ADP-ribose-1''-phosphatase, a viral function
conserved in the alpha-like supergroup. Journal of virology 2008;
82:12325-34.
Scandella E, Bolinger B, Lattmann E, Miller S, Favre S, Littman D R, Finke
D, Luther S A, Junt T, Ludewig B. Restoration of lymphoid organ integrity
through the interaction of lymphoid tissue-inducer cells with stroma of
the T cell zone. Nature immunology 2008; 9:667-75.
Bolinger B, Krebs P, Tian Y, Engeler D S, Scandella E, Miller S, Palmer D
C, Restifo N P, Clavien P A, Ludewig B. Immunologic ignorance of vascular
endothelial cells expressing minor histocompatibility antigen. Blood 2008;
111:4588-95.
Scandella E, Fink K, Junt T, Senn B M, Lattmann E, Förster R, Hengartner
H, Ludewig B. Dendritic cell-independent B cell activation during acute
virus infection: a role for early CCR7-driven B-T helper cell collaboration.
Journal of immunology (Baltimore, Md. : 1950) 2007; 178:1468-76.
Pochanke V, Koller S, Dayer R, Hatak S, Ludewig B, Zinkernagel R M,
Hengartner H, McCoy K D. Identification and characterization of a novel
antigen from the nematode Nippostrongylus brasiliensis recognized by
specific IgE. European journal of immunology 2007; 37:1275-84.
28Publikationen
Titel
Wissensch- Krebs P, Scandella E, Bolinger B, Engeler D S, Miller S, Ludewig B.
aftlicher Chronic immune reactivity against persisting microbial antigen in the
Artikel/ vasculature exacerbates atherosclerotic lesion formation. Arteriosclerosis,
Review thrombosis, and vascular biology 2007; 27:2206-13.
Zuest R, Cervantes L, Kuri T, Blakqori G, Weber F, Ludewig B, Thiel V.
Coronavirus non-structural protein 1 is a major pathogenicity factor:
implications for the rational design of coronavirus vaccines. PLoS
Pathogens 2007; 10;3(8):e109:1062-1072.
Krebs P, Kurrer M O, Kremer M, Degiuli R, Sonderegger I, Henke A, Maier
R, Ludewig B. Molecular mapping of autoimmune B cell responses in
experimental myocarditis. Journal of autoimmunity 2007; 28:224-33.
Eriksson K K, Makia D, Maier R, Ludewig B, Thiel V. Towards a
coronavirus-based HIV multigene vaccine. Clinical & developmental
immunology 2006; 13:353-60.
Klenerman P, Ludewig B. Virus scores a perfect 10. Nature medicine
2006; 12:1246-8.
Bonilla W V, Geuking M B, Aichele P, Ludewig B, Hengartner H,
Zinkernagel R M. Microchimerism maintains deletion of the donor cell-
specific CD8+ T cell repertoire. The Journal of clinical investigation 2006;
116:156-62.
Sahin U, Türeci O, Graf C, Meyer R G, Lennerz V, Britten C M, Dumrese C,
Scandella E, Wölfel T, Ludewig B. Rapid molecular dissection of viral and
bacterial immunomes. European journal of immunology 2006;
36:1049-57.
29Publikationen
Titel
Wissensch- Waeckerle-Men Y, Uetz-Von Allmen E, Fopp M, Von Moos R, Boehme C,
aftlicher Schmid H P, Ackermann D, Cerny T, Ludewig B, Groettrup M, Gillessen S.
Artikel/ Dendritic cell-based multi-epitope immunotherapy of hormone-refractory
Review prostate carcinoma. Cancer immunology, immunotherapy : CII 2006;
55:1524-33.
Junt T, Tumanov A V, Harris N, Heikenwalder M, Zeller N, Kuprash D V,
Aguzzi A, Ludewig B, Nedospasov S A, Zinkernagel R M. Expression of
lymphotoxin beta governs immunity at two distinct levels. European
journal of immunology 2006; 36:2061-75.
Schelle B, Karl N, Ludewig B, Siddell S G, Thiel V. Selective replication of
coronavirus genomes that express nucleocapsid protein. Journal of
virology 2005; 79:6620-30.
Chen L, Gui C, Luo X, Yang Q, Günther S, Scandella E, Drosten C, Bai D,
He X, Ludewig B, Chen J, Luo H, Yang Y, Yang Y, Zou J, Thiel V, Chen K,
Shen J, Shen X, Jiang H. Cinanserin is an inhibitor of the 3C-like
proteinase of severe acute respiratory syndrome coronavirus and
strongly reduces virus replication in vitro. Journal of virology 2005;
79:7095-103.
Waeckerle-Men Y, Allmen E U V, Von Moos R, Classon B J, Scandella E,
Schmid H P, Ludewig B, Groettrup M, Gillessen S. Dendritic cells
generated from patients with androgen-independent prostate cancer are
not impaired in migration and T-cell stimulation. The Prostate 2005;
64:323-31.
Maier R, Miller S, Kurrer M, Krebs P, Degiuli R, Kremer M, Scandella E,
Ludewig B. Quantification and characterization of myosin peptide-specific
CD4+ T cells in autoimmune myocarditis. J Immunol Methods 2005;
304:117-25.
30Publikationen
Titel
Wissensch- Bocharov G, Ford N J, Ludewig B. A mathematical approach for
aftlicher optimizing dendritic cell-based immunotherapy. Methods in molecular
Artikel/ medicine 2005; 109:19-34.
Review Junt T, Fink K, Förster R, Senn B, Lipp M, Muramatsu M, Zinkernagel R M,
Ludewig B, Hengartner H. CXCR5-dependent seeding of follicular niches
by B and Th cells augments antiviral B cell responses. Journal of
immunology (Baltimore, Md. : 1950) 2005; 175:7109-16.
Krebs P, Scandella E, Odermatt B, Ludewig B. Rapid functional exhaustion
and deletion of CTL following immunization with recombinant adenovirus.
Journal of immunology (Baltimore, Md. : 1950) 2005; 174:4559-66.
Ludewig B, Laman J D. The in and out of monocytes in atherosclerotic
plaques: Balancing inflammation through migration. Proceedings of the
National Academy of Sciences of the United States of America 2004;
101:11529-30.
Ludewig B, Krebs P, Scandella E. Immunopathogenesis of atherosclerosis.
Journal of leukocyte biology 2004; 76:300-6.
Scandella E, Men Y, Legler D F, Gillessen S, Prikler L, Ludewig B,
Groettrup M. CCL19/CCL21-triggered signal transduction and migration of
dendritic cells requires prostaglandin E2. Blood 2004; 103:1595-601.
Ludewig B, Krebs P, Junt T, Metters H, Ford N J, Anderson R M, Bocharov
G. Determining control parameters for dendritic cell-cytotoxic T
lymphocyte interaction. European journal of immunology 2004;
34:2407-18.
31Publikationen
Titel
Wissensch- Bocharov G, Ludewig B, Bertoletti A, Klenerman P, Junt T, Krebs P,
aftlicher Luzyanina T, Fraser C, Anderson R M. Underwhelming the immune
Artikel/ response: effect of slow virus growth on CD8+-T-lymphocyte responses.
Review Journal of virology 2004; 78:2247-54.
Maier R, Krebs P, Ludewig B. Immunopathological basis of virus-induced
myocarditis. Clinical & developmental immunology 2004; 11:1-5.
Waeckerle-Men Y, Scandella E, Uetz-Von Allmen E, Ludewig B, Gillessen
S, Merkle H P, Gander B, Groettrup M. Phenotype and functional analysis
of human monocyte-derived dendritic cells loaded with biodegradable
poly(lactide-co-glycolide) microspheres for immunotherapy. Journal of
immunological methods 2004; 287:109-24.
Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen S,
Ludewig B, Schmid H P. [Adaptive immunotherapy of the advanced
prostate cancer - cancer testis antigen (CTA) as possible target
antigens]. Aktuelle Urologie 2004; 35:326-30.
Ludewig B, Krebs P, Metters H, Tatzel J, Türeci O, Sahin U. Molecular
characterization of virus-induced autoantibody responses. The Journal of
experimental medicine 2004; 200:637-46.
Hertzig T, Scandella E, Schelle B, Ziebuhr J, Siddell S G, Ludewig B, Thiel
V. Rapid identification of coronavirus replicase inhibitors using a
selectable replicon RNA. The Journal of general virology 2004;
85:1717-25.
Prikler L, Scandella E, Men Y, Engeler D S, Diener P A, Gillessen S,
Ludewig B, Schmid H P. Adaptive Immuntherapie des fortgeschrittenen
Prostatakarzinoms : Cancer Testis Antigene (CTA) als mögliche
Zielantigene. Aktuel Urol 2004; 35:326-330.
32Publikationen
Titel
Wissensch- Junt T, Scandella E, Förster R, Krebs P, Krautwald S, Lipp M, Hengartner
aftlicher H, Ludewig B. Impact of CCR7 on priming and distribution of antiviral
Artikel/ effector and memory CTL. Journal of immunology (Baltimore, Md. :
Review 1950) 2004; 173:6684-93.
Ludewig B, Krebs P, Junt T, Bocharov G. Dendritic cell homeostasis in the
regulation of self-reactivity. Current pharmaceutical design 2003;
9:221-31.
Ludewig B. Dendritic cell vaccination and viral infection--animal models.
Current topics in microbiology and immunology 2003; 276:199-214.
Krebs P, Kurrer M, Sahin U, Türeci O, Ludewig B. Autoimmunity seen
through the SEREX-scope. Autoimmunity reviews 2003; 2:339-45.
Junt T, Nakano H, Dumrese T, Kakiuchi T, Odermatt B, Zinkernagel R M,
Hengartner H, Ludewig B. Antiviral immune responses in the absence of
organized lymphoid T cell zones in plt/plt mice. Journal of immunology
(Baltimore, Md. : 1950) 2002; 168:6032-40.
Ludewig B, Zinkernagel R M, Hengartner H. Arterial inflammation and
atherosclerosis. Trends in cardiovascular medicine 2002; 12:154-9.
Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, Xu Q.
Smooth muscle cells in transplant atherosclerotic lesions are originated
from recipients, but not bone marrow progenitor cells. Circulation 2002;
106:1834-9.
Ludewig B. Tracking arterial smooth muscle-specific T cells in the
inflamed vasculature. Advances in experimental medicine and biology
2002; 512:183-9.
33Publikationen
Titel
Wissensch- Ludewig B, Jäggi M, Dumrese T, Brduscha-Riem K, Odermatt B,
aftlicher Hengartner H, Zinkernagel R M. Hypercholesterolemia exacerbates virus-
Artikel/ induced immunopathologic liver disease via suppression of antiviral
Review cytotoxic T cell responses. Journal of immunology (Baltimore, Md. :
1950) 2001; 166:3369-76.
Ludewig B, McCoy K, Pericin M, Ochsenbein A F, Dumrese T, Odermatt B,
Toes R E, Melief C J, Hengartner H, Zinkernagel R M. Rapid peptide
turnover and inefficient presentation of exogenous antigen critically limit
the activation of self-reactive CTL by dendritic cells. Journal of
immunology (Baltimore, Md. : 1950) 2001; 166:3678-87.
Ludewig B, Junt T, Hengartner H, Zinkernagel R M. Dendritic cells in
autoimmune diseases. Current opinion in immunology 2001; 13:657-62.
Ludewig B, Bonilla W V, Dumrese T, Odermatt B, Zinkernagel R M,
Hengartner H. Perforin-independent regulation of dendritic cell
homeostasis by CD8(+) T cells in vivo: implications for adaptive
immunotherapy. European journal of immunology 2001; 31:1772-9.
Ludewig B, Ochsenbein A F, Odermatt B, Paulin D, Hengartner H,
Zinkernagel R M. Immunotherapy with dendritic cells directed against
tumor antigens shared with normal host cells results in severe
autoimmune disease. The Journal of experimental medicine 2000;
191:795-804.
Ludewig B, Maloy K J, López-Macías C, Odermatt B, Hengartner H,
Zinkernagel R M. Induction of optimal anti-viral neutralizing B cell
responses by dendritic cells requires transport and release of virus
particles in secondary lymphoid organs. European journal of immunology
2000; 30:185-96.
34Publikationen
Titel
Wissensch- Suter T, Malipiero U, Otten L, Ludewig B, Muelethaler-Mottet A, Mach B,
aftlicher Reith W, Fontana A. Dendritic cells and differential usage of the MHC
Artikel/ class II transactivator promoters in the central nervous system in
Review experimental autoimmune encephalitis. European journal of immunology
2000; 30:794-802.
Ludewig B, Barchiesi F, Pericin M, Zinkernagel R M, Hengartner H,
Schwendener R A. In vivo antigen loading and activation of dendritic cells
via a liposomal peptide vaccine mediates protective antiviral and anti-
tumour immunity. Vaccine 2000; 19:23-32.
Ludewig B, Zinkernagel R M, Hengartner H. Transgenic animal models for
virus-induced autoimmune diseases. Experimental physiology 2000;
85:653-9.
Beier K C, Hutloff A, Dittrich A M, Heuck C, Rauch A, Büchner K, Ludewig
B, Ochs H D, Mages H W, Kroczek R A. Induction, binding specificity and
function of human ICOS. European journal of immunology 2000;
30:3707-17.
Ludewig B, Freigang S, Jäggi M, Kurrer M O, Pei Y C, Vlk L, Odermatt B,
Zinkernagel R M, Hengartner H. Linking immune-mediated arterial
inflammation and cholesterol-induced atherosclerosis in a transgenic
mouse model. Proceedings of the National Academy of Sciences of the
United States of America 2000; 97:12752-7.
Ochsenbein A F, Klenerman P, Karrer U, Ludewig B, Pericin M, Hengartner
H, Zinkernagel R M. Immune surveillance against a solid tumor fails
because of immunological ignorance. Proceedings of the National
Academy of Sciences of the United States of America 1999; 96:2233-8.
35Publikationen
Titel
Wissensch- Maloy K J, Burkhart C, Freer G, Rülicke T, Pircher H, Kono D H,
aftlicher Theofilopoulos A N, Ludewig B, Hoffmann-Rohrer U, Zinkernagel R M,
Artikel/ Hengartner H. Qualitative and quantitative requirements for CD4+ T cell-
Review mediated antiviral protection. Journal of immunology (Baltimore, Md. :
1950) 1999; 162:2867-74.
Ludewig B, Oehen S, Barchiesi F, Schwendener R A, Hengartner H,
Zinkernagel R M. Protective antiviral cytotoxic T cell memory is most
efficiently maintained by restimulation via dendritic cells. Journal of
immunology (Baltimore, Md. : 1950) 1999; 163:1839-44.
Ludewig B, Odermatt B, Ochsenbein A F, Zinkernagel R M, Hengartner H.
Role of dendritic cells in the induction and maintenance of autoimmune
diseases. Immunological reviews 1999; 169:45-54.
Ludewig B, Odermatt B, Landmann S, Hengartner H, Zinkernagel R M.
Dendritic cells induce autoimmune diabetes and maintain disease via de
novo formation of local lymphoid tissue. The Journal of experimental
medicine 1998; 188:1493-501.
Ludewig B, Ehl S, Karrer U, Odermatt B, Hengartner H, Zinkernagel R M.
Dendritic cells efficiently induce protective antiviral immunity. Journal of
virology 1998; 72:3812-8.
Häusser G, Ludewig B, Gelderblom H R, Tsunetsugu-Yokota Y, Akagawa K,
Meyerhans A. Monocyte-derived dendritic cells represent a transient
stage of differentiation in the myeloid lineage. Immunobiology 1997;
197:534-42.
Ludewig B, Gelderblom H R, Becker Y, Schäfer A, Pauli G. Transmission of
HIV-1 from productively infected mature Langerhans cells to primary
CD4+ T lymphocytes results in altered T cell responses with enhanced
production of IFN-gamma and IL-10. Virology 1996; 215:51-60.
36Publikationen
Titel
Wissensch- Ludewig B, Henn V, Schröder J M, Graf D, Kroczek R A. Induction,
aftlicher regulation, and function of soluble TRAP (CD40 ligand) during interaction
Artikel/ of primary CD4+ CD45RA+ T cells with dendritic cells. European journal
Review of immunology 1996; 26:3137-43.
Ludewig B, Graf D, Gelderblom H R, Becker Y, Kroczek R A, Pauli G.
Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP
(CD40-ligand) and TNF-alpha, but strongly enhanced by interleukin-10.
European journal of immunology 1995; 25:1943-50.
Ludewig B, Holzmeister J, Gentile M, Gelderblom H R, Rokos K, Becker Y,
Pauli G. Replication pattern of human immunodeficiency virus type 1 in
mature Langerhans cells. The Journal of general virology 1995; 76 ( Pt
6):1317-25.
Holzmeister J, Ludewig B, Pauli G, Simon D. Sequence specific binding of
the transcription factor c-Ets1 to the human immunodeficiency virus type
I long terminal repeat. Biochemical and biophysical research
communications 1993; 197:1229-33.
Buch Ludewig B (Hrsg.) ; Hoffmann M (Hrsg.): Adoptive Immunotherapy :
Methods and Protocols. Methods in Molecular Medicine. Totowa, New
Jersey : Humana Press, 2005.- ISBN 1-59259-862-5
Buchkapitel Ludewig B ; Laman J D: The immune system in the pathogenesis of
vascular disease. In: Essentials of restenosis for the interventional
cardiologist. Totowa, New Jersey : Humana Press, 2007.- ISBN
978-1-58829-491-3, S. 85-130
Ludewig B ; Krebs P: A transgenic mouse model for virus-induced
vasculitis. In: Xu Q (Hrsg.): A Handbook of Mouse Models of
Cardiovascular Disease. Chichester, UK : Wiley, 2006.- ISBN
978-0-470-01610-7, S. 321-332
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