Publikationen 2019 - Kerckhoff-Klinik
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Inhaltsverzeichnis Seite Vorwort 3 Publikationen - Kardiologie 6 Publikationen - Herzchirurgie 20 Publikationen - Rheumatologie & Klinische Immunologie & Physikalische Medizin & Osteologie 24 Publikationen - Thoraxchirurgie 30 Publikationen - Allgemeine & Onkologische Pneumologie 31 Publikationen - Gefäßchirurgie & Angiologie 38 Publikationen - Labormedizin & Krankenhaushygiene 42 Publikationen - Psychokardiologie 46 Publikationen - Diagnostische Radiologie 50 Publikationen - Heart & Brain Research Group 54 Publikationen - Kerckhoff-Klinik Forschungsgesellschaft mbH 58 2
Vorwort Liebe Leserinnen und Leser, mit großer Freude dürfen wir Ihnen den Publikationsbericht 2019 der Kerckhoff-Klinik vorlegen, der einmal mehr die erfolgreiche und engagierte Forschungsarbeit sowohl auf nationaler wie auch inter- nationaler Ebene eindrucksvoll dokumentiert. Unverändert wurden fächerübergreifende Forschungs- und Publikationsthemen mit gleichrangiger Grundlagen- und Anwendungsorientierung auf höchstem Niveau realisiert. Auch in 2019 wurden zahlreiche Preise und Ehrungen an die Wissenschaftler/Innen unseres Campus verliehen, was die ausgezeichnete Expertise und die hohe qualitative Ausrichtung der Forschung unterstreicht. Die ambulante wie auch stationäre Patientenversorgung der Kerckhoff-Klinik erfüllt nicht zuletzt aufgrund der sehr erfolgreichen Forschungstätigkeit höchste medizinische Maßstäbe. Die umfangreiche wissenschaftliche Netzwerkbildung unseres Campus Kerckhoff der Universität Gießen spiegelt sich durch die Verbindung zur Goethe-Universität Frankfurt/Main, der Zugehörigkeit zum Exzellenz-Cluster Cardio-Pulmonary System (ECCPS) an der Justus-Liebig-Universität Gießen, dem Deutschen Zentrum für Herz-Kreislauf-Forschung (DZHK) e. V., die Zugehörigkeit zum Sonder- forschungsbereich 1213 „Pulmonale Hypertonie und Cor pulmonale“ der Deutschen Forschungsge- meinschaft (DFG) e. V., Rheumazentrum Hessen, The European Scleroderma Trials and Research Group, Deutsches Netzwerk für Systemische Sklerodermie, Myositis Netzwerk Hessen, European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases sowie der Regionalen Expertenkommission Osteoporose (REKO) Deutschland und Hessen wider. Allen Beteiligten, die mit unermesslichem Einsatz die wissenschaftliche Expertise am Campus Kerckhoff kontinuierlich fortgeführt haben sei an dieser Stelle gedankt! Möge der vorliegende Publikationsbericht als Stimulanz für die zukünftige proaktive wissenschaft- liche Forschung dienen. Mit freundlichen Grüßen Univ.- Prof. Dr. med. Christian Hamm Univ.-Prof. Dr. med. Uwe Lange Direktor Abt. Kardiologie Direktor Osteologie & Physikalische Medizin Direktor Forschung Stellv. Direktor Rheumatologie & Klinische Immunologie der Kerckhoff-Klinik GmbH der Kerckhoff-Klinik GmbH Direktor Med. Klinik I, Kardiologie Universitätsklinikum Gießen Beauftragter für den Publikationsbericht 3
Kardiologie PUBLIKATIONEN 2019 Originalarbeiten & Übersichtsartikel 1. Akkaya E, Berkowitsch A, Rieth A, Erkapic D, Hamm CW, Neumann T, Kuniss M. Clinical out- come and left atrial function after left atrial roof ablation using the cryoballoon technique in patients with symptomatic persistent atrial fibrillation. Int J Cardiol. 2019 Oct 1; 292: 112-118. 2. Ali ZA, Nef H, Escaned J, Werner N, Banning AP, Hill JM, De Bruyne B, Montorfano M, Lefevre T, Stone GW, Crowley A, Matsumura M, Maehara A, Lansky AJ, Fajadet J, Di Mario C. Safety and Effectiveness of Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Coronary Stenoses: The Disrupt CAD II Study. Circ Cardiovasc Interv. 2019 Oct; 12(10): e008434. 3. Aslam M, Troidl C, Tanislav C, Rohrbach S, Gunduz D, Hamm CW. Inhibition of Protein Prenyla- tion of GTPases Alters Endothelial Barrier Function. Int J Mol Sci. 2019 Dec 18; 21(1). 4. Bandorski D, Holtgen R, Ghofrani A, Johnson V, Schmitt J. [Arrhythmias in patients with pulmo- nary hypertension and chronic lung disease]. Herzschrittmacherther Elektrophysiol. 2019 Sep; 30(3): 234-239. 5. Barth S, Reents W, Zacher M, Kerber S, Diegeler A, Schieffer B, Schreiber M, Lauer B, Kuntze T, Dahmer M, Hamm C, Hamm K. Multicentre propensity-matched comparison of transcatheter aortic valve implantation using the ACURATE TA/neo self-expanding versus the SAPIEN 3 bal- loon-expandable prosthesis. EuroIntervention. 2019 Nov 20; 15(10): 884-891. 6. Bauer P, Henni S, Dörr O, Bauer T, Hamm CW, Most A. High prevalence of vitamin D insufficien- cy in professional handball athletes. Phys Sportsmed. 2019 Feb; 47(1): 71-77. 7. Bauer P, Kraushaar L, Holscher S, Tajmiri-Gondai S, Dörr O, Nef H, Hamm C, Most A. Elite ath- letes as research model: vitamin D insufficiency associates with elevated central blood pressure in professional handball athletes. Eur J Appl Physiol. 2019 Aug 19; 119: 2265–2274. 8. Bauer P, Uebellacker F, Mitter B, Aigner AJ, Hasenoehrl T, Ristl R, Tschan H, Seitz LB. Combin- ing higher-load and lower-load resistance training exercises: A systematic review and meta- analysis of findings from complex training studies. J Sci Med Sport. 2019 Jul; 22(7): 838-851. 9. Bauer T, Zeymer U, Diallo A, Vicaut E, Bolognese L, Cequier A, Huber K, Montalescot G, Hamm CW, Van't Hof AW. Impact of preprocedural TIMI flow on clinical outcome in low-risk patients with ST-elevation myocardial infarction: Results from the ATLANTIC study. Catheter Cardiovasc Interv. 2019 May 8: In press. 10. Baumann S, Hirt M, Schoepf UJ, Rutsch M, Tesche C, Renker M, Golden JW, Buss SJ, Becher T, Bojara W, Weiss C, Papavassiliu T, Akin I, Borggrefe M, Schoenberg SO, Haubenreisser H, Over- hoff D, Lossnitzer D. Correlation of machine learning computed tomography-based fractional flow reserve with instantaneous wave free ratio to detect hemodynamically significant coronary stenosis. Clin Res Cardiol. 2019 Oct 29: In press. 11. Baumann S, Kryeziu P, Tesche C, Shuler DC, Becher T, Rutsch M, Behnes M, Stach K, Jacobs BE, Renker M, Henzler T, Haubenreisser H, Schoenberg SO, Weiss C, Borggrefe M, Schwemmer C, Schoepf UJ, Akin I, Lossnitzer D. Association of Serum Lipid Profile With Coronary Computed Tomographic Angiography-derived Morphologic and Functional Quantitative Plaque Markers. J Thorac Imaging. 2019 Jan; 34(1): 26-32. 12. Baumann S, Renker M, Schoepf UJ, De Cecco CN, Coenen A, De Geer J, Kruk M, Kim YH, Al- brecht MH, Duguay TM, Jacobs BE, Bayer RR, Litwin SE, Weiss C, Akin I, Borggrefe M, Yang DH, Kepka C, Persson A, Nieman K, Tesche C. Gender differences in the diagnostic performance of machine learning coronary CT angiography-derived fractional flow reserve -results from the MACHINE registry. Eur J Radiol. 2019 Sep 7; 119: 108657. 13. Bavendiek U, Berliner D, Davila LA, Schwab J, Maier L, Philipp SA, Rieth A, Westenfeld R, Pior- kowski C, Weber K, Hanselmann A, Oldhafer M, Schallhorn S, von der Leyen H, Schroder C, Veltmann C, Stork S, Böhm M, Koch A, Bauersachs J. Rationale and design of the DIGIT-HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double-blind, placebo-controlled study. Eur J Heart Fail. 2019 May; 21(5): 676-684. 14. Bekeredjian R, Szabo G, Balaban U, Bleiziffer S, Bauer T, Ensminger S, Frerker C, Herrmann E, Beyersdorf F, Hamm C, Beckmann A, Möllmann H, Karck M, Katus HA, Walther T. Patients at low surgical risk as defined by the Society of Thoracic Surgeons Score undergoing isolated in- terventional or surgical aortic valve implantation: in-hospital data and 1-year results from the German Aortic Valve Registry (GARY). Eur Heart J. 2019 May; 40(17): 1323-1330. 6
Kardiologie 15. Blachutzik F, Achenbach S, Marwan M, Tröbs M, Boeder N, Doerr O, Weissner M, Bauer T, Nef H, Hamm C, Schlundt C. OCT-assessment of scaffold resorption: Analysis of strut intensity by a new resorption index for poly-l-lactic acid bioresorbable vascular scaffolds. Catheter Cardio vasc Interv. 2019 Apr 3; 94(7): 928-935. 16. Blachutzik F, Achenbach S, Tröbs M, Marwan M, Weissner M, Nef H, Schlundt C. Effect of non- compliant balloon postdilatation on magnesium-based bioresorbable vascular scaffolds. Catheter Cardiovasc Interv. 2019 Feb 1; 93(2): 202-207. 17. Boeckel JN, Perret MF, Glaser SF, Seeger T, Heumuller AW, Chen W, John D, Kokot KE, Katus HA, Haas J, Lackner MK, Kayvanpour E, Grabe N, Dieterich C, von Haehling S, Ebner N, Hunecke S, Leuschner F, Fichtlscherer S, Meder B, Zeiher AM, Dimmeler S, Keller T. Identification and regulation of the long non-coding RNA Heat2 in heart failure. J Mol Cell Cardiol. 2019 Jan; 126: 13-22. 18. Boeder NF, Dörr O, Bauer T, Elsässer A, Möllmann H, Achenbach S, Hamm CW, Nef HM. Effect of plaque composition, morphology, and burden on DESolve novolimus-eluting bioresorbable vascular scaffold expansion and eccentricity — An optical coherence tomography analysis. Cardiovasc Revasc Med. 2019 Jun; 20(6): 480-484. 19. Burch AE, Scherr D, Rieth A, Griffin J, Bianco NR, Odeneg T, Sears SF. Wearable Cardioverter Defibrillator-Guided 6-Min Walk Test Performed at Home Is Accurate and Reliable: RESULTS OF THE TRENDS STUDY. J Cardiopulm Rehabil Prev. 2019 Jul 22: In press. 20. Busch S, Eckardt L, Sommer P, Meyer C, Bonnemeier H, Thomas D, Neuberger HR, Tilz RR, Steven D, von Bary C, Kuniss M, Voss F, Estner HL. [Premature ventricular contractions and tachycardia in a structurally normal heart : Idiopathic PVC and VT]. Herzschrittmacherther El ektrophysiol. 2019 Jun; 30(2): 212-224. 21. Butty A, Gencer B, Koskinas KC, Carballo D, Raber L, Klingenberg R, Matter CM, Lüscher TF, Windecker S, Müller O, Rodondi N, Mach F, Nanchen D. Control of cardiovascular risk factors and health behaviors in patients post acute coronary syndromes eligible for protein convertase subtilisin/kexin-9 inhibitors. Int J Cardiol. 2019 Oct 9: In press. 22. Carballo D, Rodondi N, Auer R, Carballo S, Nanchen D, Raber L, Klingenberg R, Keller PF, Heg D, Juni P, Muller O, Matter CM, Lüscher TF, Windecker S, Mach F, Gencer B. Clinical impact of a structured secondary cardiovascular prevention program following acute coronary syndromes: A prospective multicenter healthcare intervention. PLoS One. 2019 14(2): e0211464. 23. D'Ascenzo F, Biole C, Raposeiras-Roubin S, Gaido F, Abu-Assi E, Kinnaird T, Ariza-Sole A, Liebetrau C, Manzano-Fernandez S, Boccuzzi G, Henriques JPS, Templin C, Wilton SB, Omede P, Velicki L, Xanthopoulou I, Correia L, Cerrato E, Rognoni A, Fabrizio U, Nunez-Gil I, Montabone A, Taha S, Fujii T, Durante A, Song X, Gili S, Magnani G, Autelli M, Bongiovanni F, Grosso A, Kawaji T, Blanco PF, Garay A, Quadri G, Alexopoulos D, Queija BC, Huczek Z, Paz RC, Gonzalez- Juanatey JR, Fernandez MC, Nie SP, Pousa IM, Kawashiri MA, Rettegno S, Gallo D, Morbiducci U, Conrotto F, Dominguez-Rodriguez A, Valdes M, Cequier A, Iniguez-Romo A, Biondi-Zoccai G, Stone GW, De Ferrari GM. Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries. Am Heart J. 2019 Nov 11; 220: 108-115. 24. De Backer O, Dangas GD, Jilaihawi H, Leipsic JA, Terkelsen CJ, Makkar R, Kini AS, Veien KT, Abdel-Wahab M, Kim WK, Balan P, Van Mieghem N, Mathiassen ON, Jeger RV, Arnold M, Mehran R, Guimaraes AHC, Norgaard BL, Kofoed KF, Blanke P, Windecker S, Sondergaard L. Reduced Leaflet Motion after Transcatheter Aortic-Valve Replacement. N Engl J Med. 2019 Nov 16: In press. 25. De Faria AP, Modolo R, Chichareon P, Chang CC, Kogame N, Tomaniak M, Takahashi K, Rademaker-Havinga T, Wykrzykowska J, de Winter RJ, Ferreira RC, Sousa A, Lemos PA, Garg S, Hamm C, Juni P, Vranckx P, Valgimigli M, Windecker S, Onuma Y, Steg PG, Serruys PW. Association of Pulse Pressure With Clinical Outcomes in Patients Under Different Antiplatelet Strategies After Percutaneous Coronary Intervention: Analysis of GLOBAL LEADERS. Can J Cardiol. 2019 Oct 19: In press. 26. Desch S, Freund A, Graf T, Fichtlscherer S, Haake H, Preusch M, Hammer F, Akin I, Christ M, Liebetrau C, Skurk C, Steiner S, Voigt I, Schmitz R, Mudra H, Ledwoch J, Menck N, Horstkotte J, Pels K, Lahmann AL, Otto S, Lenk K, Ohlow MA, Hassager C, Nordbeck P, Zeymer U, Jobs A, de Waha-Thiele S, Olbrich D, Konig I, Klinge K, Thiele H. Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST- segment elevation: Design and rationale of the TOMAHAWK trial. Am Heart J. 2019 Mar; 209: 20- 28. 7
Kardiologie 27. Diouf K, Elsner L, Rohr M, Wolter JS, Dörr O, Hamm CW, Liebetrau C, Keller T. Anti-citrullinated protein antibodies are not associated with extent of disease or prognosis in patients with coronary artery disease. Clin Chem Lab Med. 2019 Jun 26; 57(7): e159-e161. 28. Dörr O, Liebetrau C, Weferling M, Hoffmann F, Forderer N, Keller T, Boeder N, Blachutzik F, Keranov S, Bauer P, Bauer T, Hamm CW, Nef H. Fractional flow reserve and frequency of PCI in patients with coronary artery disease. Herz. 2019 Sep 4: In press. 29. Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bönig H, Dimmeler S, Zeiher AM, Rieger MA. Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis. Haematologica. 2019 Nov 7: In press. 30. Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brune B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA. Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure. JAMA Cardiol. 2019 Jan 1; 4(1): 25-33. 31. Dschietzig TB, Kellner KH, Sasse K, Boschann F, Klusener R, Ruppert J, Armbruster FP, Bankovic D, Meinitzer A, Mitrovic V, Melzer C. Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease. Kidney Blood Press Res. 2019 Aug 6: 1-12. 32. Elsner LK, Jeinsen BV, Grün D, Wolter JS, Weferling M, Diouf K, Kriechbaum S, Troidl C, Dörr O, Nef H, Hamm CW, Liebetrau C, Keller T. Prognostic performance of the ESC SCORE and its Ger man recalibrated versions in primary and secondary prevention. Eur J Prev Cardiol. 2019 Aug 18: In press 33. Ettorre A, Alejandre-Lafont E, Syed FH, Most A, Hamm CW, Bauer P. Ultrasound Diagnosed Ra re Partial Nephrectomy Complication. Int J Angiol. 2019 Mar; 28(1): 25-27 34. Filippo O, D'Ascenzo F, Raposeiras-Roubin S, Abu-Assi E, Peyracchia M, Bocchino PP, Kinnaird T, Ariza-Sole A, Liebetrau C, Manzano-Fernandez S, Boccuzzi G, Henriques JPS, Templin C, Wilton SB, Omede P, Velicki L, Xanthopoulou I, Correia L, Cerrato E, Rognoni A, Fabrizio U, Nunez-Gil I, Iannaccone M, Montabone A, Taha S, Fujii T, Durante A, Song X, Gili S, Magnani G, Varbella F, Kawaji T, Blanco PF, Garay A, Quadri G, Alexopoulos D, Queija BC, Huczek Z, Paz RC, Gonzalez Juanatey JR, Fernandez MC, Nie SP, Pousa IM, Kawashiri MA, Gallo D, Morbiducci U, Conrotto F, Montefusco A, Dominguez-Rodriguez A, Lopez-Cuenca A, Cequier A, Iniguez-Romo A, Usmiani T, Rinaldi M, De Ferrari GM. P2Y12 inhibitors in acute coronary syndrome patients with renal dysfunction: an analysis from the RENAMI and BleeMACS projects. Eur Heart J Cardiovasc Pharmacother. 2019 Sep 12: In press 35. Fischer-Rasokat U, Renker M, Liebetrau C, van Linden A, Arsalan M, Weferling M, Rolf A, Doss M, Möllmann H, Walther T, Hamm CW, Kim WK. 1-Year Survival After TAVR of Patients With Low-Flow, Low-Gradient and High-Gradient Aortic Valve Stenosis in Matched Study Populations. JACC Cardiovasc Interv. 2019 Apr 22; 12(8): 752-763. 36. Fischer-Rasokat U, Renker M, Liebetrau C, Weferling M, Rolf A, Doss M, Möllmann H, Walther T, Hamm CW, Kim WK. Outcome of patients with heart failure after transcatheter aortic valve implantation. PLoS One. 2019 14(11): e0225473. 37. Franzone A, McFadden E, Leonardi S, Piccolo R, Vranckx P, Serruys PW, Benit E, Liebetrau C, Janssens L, Ferrario M, Zurakowski A, Diletti R, Dominici M, Huber K, Slagboom T, Buszman P, Bolognese L, Tumscitz C, Bryniarski K, Aminian A, Vrolix M, Petrov I, Garg S, Naber C, Prokopczuk J, Hamm C, Steg PG, Heg D, Juni P, Windecker S, Valgimigli M. Ticagrelor Alone Versus Dual Antiplatelet Therapy From 1 Month After Drug-Eluting Coronary Stenting. J Am Coll Cardiol. 2019 Nov 5; 74(18): 2223-2234. 38. Fujita B, Schmidt T, Bleiziffer S, Bauer T, Beckmann A, Bekeredjian R, Möllmann H, Walther T, Landwehr S, Hamm C, Beyersdorf F, Katus HA, Harringer W, Ensminger S, Frerker C. Impact of new pacemaker implantation following surgical and transcatheter aortic valve replacement on 1-year outcome. Eur J Cardiothorac Surg. 2019 Jun 14: In press. 39. Gaede L, Blumenstein J, Liebetrau C, Dörr O, Kim WK, Nef H, Husser O, Gulker J, Elsässer A, Hamm CW, Achenbach S, Möllmann H. Transvascular transcatheter aortic valve implantation in 2017. Clin Res Cardiol. 2019 Jun 24: In press. 40. Gencer B, Carballo D, Nanchen D, Koskinas KC, Klingenberg R, Raber L, Auer R, Carballo S, Heg D, Windecker S, Lüscher TF, Matter CM, Rodondi N, Mach F. Intensified lipid lowering using ezetimibe after publication of the IMPROVE-IT trial: A contemporary analysis from the SPUM- ACS cohort. Int J Cardiol. 2019 Dec 10: In press. 8
Kardiologie 41. Gencer B, Rigamonti F, Nanchen D, Vuilleumier N, Kern I, Aghlmandi S, Klingenberg R, Raber L, Auer R, Carballo D, Carballo S, Heg D, Windecker S, Lüscher TF, Matter CM, Rodondi N, Mach F. Prognostic value of elevated lipoprotein(a) in patients with acute coronary syndromes. Eur J Clin Invest. 2019 Apr 2: e13117. 42. Gencer B, Vuilleumier N, Nanchen D, Collet TH, Klingenberg R, Raber L, Auer R, Carballo D, Carballo S, Aghlmandi S, Heg D, Windecker S, Lüscher TF, Matter CM, Rodondi N, Mach F. Prognostic value of total testosterone levels in patients with acute coronary syndromes. Eur J Prev Cardiol. 2019 Jun 1: 2047487319853343. 43. Giannitsis E, Clifford P, Slagman A, Ruedelstein R, Liebetrau C, Hamm C, Honnart D, Huber K, Vollert JO, Simonelli C, Schroder M, Wiemer JC, Mueller-Hennessen M, Schroer H, Kastner K, Mockel M. Multicentre cross-sectional observational registry to monitor the safety of early dis charge after rule-out of acute myocardial infarction by copeptin and troponin: the Pro-Core registry. BMJ Open. 2019 Jul 23; 9(7): e028311. 44. Gori T, Achenbach S, Riemer T, Mehilli J, Nef HM, Naber C, Richardt G, Wohrle J, Zahn R, Neumann T, Kastner J, Schmermund A, Hamm C, Münzel T. Hybrid Coronary Percutaneous Treatment with Metallic Stents and Everolimus-Eluting Bioresorbable Vascular Scaffolds: 2- years Results from the GABI-R Registry. J Clin Med. 2019 May 30; 8(6): 1-13. 45. Günduz D, Troidl C, Tanislav C, Rohrbach S, Hamm C, Aslam M. Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation. Front Physiol. 2019 10: 1387. 46. Haller PM, Boeddinghaus J, Neumann JT, Sorensen NA, Hartikainen TS, Gossling A, Nestelberger T, Twerenbold R, Lehmacher J, Keller T, Zeller T, Blankenberg S, Mueller C, Westermann D. Performance of the ESC 0/1-h and 0/3-h Algorithm for the Rapid Identification of Myocardial Infarction Without ST-Elevation in Patients With Diabetes. Diabetes Care. 2019 Dec 16. 47. Hamm CW, Dörr O, Woehrle J, Krackhardt F, Ince H, Zeus T, Bergland J, Piot C, Roubille F, Schult I, Allocco DJ, Nef H. Drug-coated Balloons for the Treatment of Coronary In-stent Restenosis: A Multicentre, Randomised Controlled Clinical Study. EuroIntervention. 2019 Nov 19 48. Henni S, Bauer P, Le Meliner T, Hersant J, Papon X, Daligault M, Chretien JM, Ammi M, Picquet J, Abraham P. High prevalence of exercise-induced ischemia in the asymptomatic limb of patients with apparently strictly unilateral symptoms and unilateral peripheral artery disease. Ther Adv Cardiovasc Dis. 2019 Jan-Dec; 13: 1753944718819063. 49. Hermida JS, Chen J, Meyer C, Iacopino S, Arena G, Pavlovic N, Velagic V, Healey S, Packer DL, Pitschner HF, de Asmundis C, Kuniss M, Chierchia GB. Cryoballoon catheter ablation versus antiarrhythmic drugs as a first-line therapy for patients with paroxysmal atrial fibrillation: Rationale and design of the international Cryo-FIRST study. Am Heart J. 2019 Dec 18; 222: 64-72. 50. Hoffmann E, Straube F, Wegscheider K, Kuniss M, Andresen D, Wu LQ, Tebbenjohanns J, Noelker G, Tilz RR, Chun JKR, Franke A, Stellbrink C, Garcia-Alberola A, Dorwarth U, Metzner A, Ouarrak T, Brachmann J, Kuck KH, Senges J. Outcomes of cryoballoon or radiofrequency ablation in symptomatic paroxysmal or persistent atrial fibrillation. Europace. 2019 Sep 1; 21(9): 1313-1324. 51. Hoffmann J, Fiser K, Liebetrau C, Staubach N, Kost D, Voss S, Heiden AZ, Dörr O, Lipps C, Nef HM, Möllmann H, Hamm CW, Keller T, Troidl C. High-Content Immunophenotyping and Hierarchical Clustering Reveal Sources of Heterogeneity and New Surface Markers of Human Blood Monocyte Subsets. Thromb Haemost. 2019 Dec 30: In press. 52. Holzamer A, Kim WK, Ruck A, Sathananthan J, Keller L, Cosma J, Bauer T, Nef H, Amat-Santos I J, Brinkert M, Husser O, Pellegrini C, Schofer J, Nerla R, Montorfano M, Giannini F, Stella P, Kuwata S, Hilker M, Castriota F, Ussia GP, Webb JG, Nietlispach F, Toggweiler S. Valve-in-Valve Implantation Using the ACURATE Neo in Degenerated Aortic Bioprostheses: An International Multicenter Analysis. JACC Cardiovasc Interv. 2019 Nov 25; 12(22): 2309-2316. 53. Husain-Syed F, Birk HW, Ronco C, Schormann T, Tello K, Richter MJ, Wilhelm J, Sommer N, Steyerberg E, Bauer P, Walmrath HD, Seeger W, McCullough PA, Gall H, Ghofrani HA. Doppler- Derived Renal Venous Stasis Index in the Prognosis of Right Heart Failure. J Am Heart Assoc. 2019 Nov 5; 8(21): e013584. 54. Huseynov A, Baumann S, Nef H, Riemer T, Schneider S, Pfannenbecker T, Achenbach S MehilliJ, Munzel T, Gori T, Wohrle J, Zahn R, Kastner J, Schmermund A, Richardt G, Hamm CW, Akin I. Comparison between treatment of "established" versus complex "off-label" coronary lesions with Absorb((R)) bioresorbable scaffold implantation: results from the GABI-R((R)) registry. Clin Res Cardiol. 2019 Jun 29: In press. 9
Kardiologie 55. Husser O, Pellegrini C, Kim WK, Holzamer A, Pilgrim T, Toggweiler S, Schafer U, Blumenstein J, Deuschl F, Rheude T, Joner M, Hilker M, Hengstenberg C, Möllmann H. Transcatheter Valve SELECTion in Patients With Right Bundle Branch Block and Impact on Pacemaker Implantations. JACC Cardiovasc Interv. 2019 Sep 23; 12(18): 1781-1793. 56. Jayarajan V, Appukuttan A, Aslam M, Reusch P, Regitz-Zagrosek V, Ladilov Y. Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasis. Cell Mol Life Sci. 2019 Jun 6; 76(24): 4945-4959. 57. Johnson V, Hamm CW, Schmitt J. [Device-device interaction]. Herzschrittmacherther Elektrophysiol. 2019 Jun; 30(2): 183-190. 58. Johnson V, Schmitt J. A Chicken or Egg Dilemma: Patients With Atrial Fibrillation and Poor Prognostic Outcome in Acute Coronary Syndrome. Rev Esp Cardiol (Engl Ed). 2019 May; 72(5): 367-368. 59. Juenemann M, Nef H, Möllmann H, Singh P, Troidl C, Schramm P, Kaps M, Gerriets T, Blaes F, Tschernatsch M. No evidence for humoral autoimmunity against cardiomyocytes, adrenergic or muscarinic receptors in patients with Tako-Tsubo cardiomyopathy. Immunobiology. 2019 Mar; 224(2): 220-222. 60. Keller T, Hamm CW. High-sensitivity cardiac troponin assays: finally ready for prime time? Nat Rev Cardiol. 2019 Mar; 16(3): 135-136. 61. Keranov S, Kim WK, Arsalan M, Renker M, Keller T, Bauer T, Dörr O, Nef HM, Gaede L, Möllmann H, Walther T, Hamm CW, Liebetrau C. Predictive value of preprocedural procalcitonin for short- and long-term mortality after transfemoral transcatheter aortic valve implantation. Heart Vessels. 2019 Jun 7; 34: 1993–2001. 62. Kim HO, Kim CJ, Kim W, Cho JM, Soeda T, Takano M, Yan BP, Crea F, Niccoli G, Vergallo R, Minami Y, Higuma T, Kimura S, Boeder NF, Nef H, Adriaenssens T, Kurihara O, Thondapu V, Russo M, Yamamoto E, Sugiyama T, Lee H, Kakuta T, Yonetsu T, Jang IK. Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome. J Thromb Thrombolysis. 2019 Oct 9: In press. 63. Kim WK, Brinkert M, Mangner N, Gatto F, Husser O, Renker M, Liebetrau C, Gasior T, Doss M, Walther T, Hamm C, Linke A, Toggweiler S, Möllmann H. Transfemoral implantation of the ACU RATE neo prosthesis using a low-profile expandable introducer system: A multicenter registry. Int J Cardiol. 2019 Apr 15; 281: 76-81. 64. Kim WK, Hamm CW. TAVR for mixed aortic valve disease - A good companionship? Int J Cardiol. 2019 Oct 25: In press. 65. Kim WK, Liebetrau C, Fischer-Rasokat U, Renker M, Rolf A, Doss M, Möllmann H, Nef H, Walther T, Hamm CW. Challenges of recognizing bicuspid aortic valve in elderly patients undergoing TAVR. Int J Cardiovasc Imaging. 2019 Oct 5: In press. 66. Kim WK, Renker M, Rolf A, Fischer-Rasokat U, Wiedemeyer J, Doss M, Mollmann H, Walther T, Nef H, Hamm CW, Liebetrau C. Annular versus supra-annular sizing for TAVI in bicuspid aortic valve stenosis. EuroIntervention. 2019 May 23; 15(3): e231-e238. 67. Kim WK, Schafer U, Tchetche D, Nef H, Arnold M, Avanzas P, Rudolph T, Scholtz S, Barbanti M, Kempfert J, Mangieri A, Lauten A, Frerker C, Yoon SH, Holzamer A, Praz F, De Backer O, Toggweiler S, Blumenstein J, Purita P, Tarantini G, Thilo C, Wolf A, Husser O, Pellegrini C, Burgdorf C, Antolin RAH, Diaz VAJ, Liebetrau C, Schofer N, Möllmann H, Eggebrecht H, Sonder gaard L, Walther T, Pilgrim T, Hilker M, Makkar R, Unbehaun A, Borgermann J, Moris C, Achenbach S, Dörr O, Brochado B, Conradi L, Hamm CW. Incidence and outcome of peri- pro cedural transcatheter heart valve embolization and migration: the TRAVEL registry (TranscatheteR HeArt Valve EmboLization and Migration). Eur Heart J. 2019 Jun 23; 40(38): 3156- 3165. 68. Klingenberg R, Schlager O, Limacher A, Mean M, Vuilleumier N, Beer JH, Staub D, Frauchiger B, Aschwanden M, Lammle B, Righini M, Egloff M, Osterwalder J, Angelillo-Scherrer A, Kucher N, Banyai M, Rodondi N, von Eckardstein A, Aujesky D, Husmann M, Matter CM. Risk stratification of elderly patients with acute pulmonary embolism. Eur J Clin Invest. 2019 Jun 27: e13154. 69. Klok FA, Pruefer D, Rolf A, Konstantinides SV. Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension. Eur Heart J. 2019 Mar 14; 40(11): 944. 10
Kardiologie 70. Kölmel S, Hobohm L, Kaberich A, Krieg VJ, Bochenek ML, Wenzel P, Wiedenroth CB, Liebetrau C, Hasenfuss G, Mayer E, Konstantinides SV, Schafer K, Guth S, Lankeit M. Potential Involvement of Osteopontin in Inflammatory and Fibrotic Processes in Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension. Thromb Haemost. 2019 Aug; 119(8): 1332-1346. 71. Kostic S, Guth S, Bachmann G, Hamm CW, Klingenberg R. Sarcoma of the pulmonary artery mimicking pulmonary artery embolism. Eur Heart J. 2019 May 7; 40(33): 2824. 72. Kriechbaum SD, Boeder NF, Gaede L, Arnold M, Vigelius-Rauch U, Roth P, Sander M, Böning A, Bayer M, Elsässer A, Möllmann H, Hamm CW, Nef HM. Mitral valve leaflet repair with the new PASCAL system: early real-world data from a German multicentre experience. Clin Res Cardiol. 2019 Aug 26: In press. 73. Kriechbaum SD, Wiedenroth CB, Hesse ML, Ajnwojner R, Keller T, Wolter JS, Haas M, Roller FC, Breithecker A, Rieth AJ, Guth S, Rolf A, Hamm CW, Mayer E, Liebetrau C. Development of renal function during staged balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension. Scand J Clin Lab Invest. 2019 Apr 15; 79(4): 268-275. 74. Krieg VJ, Hobohm L, Liebetrau C, Guth S, Kolmel S, Troidl C, Mayer E, Konstantinides SV, Wiedenroth CB, Lankeit M. Risk factors for chronic thromboembolic pulmonary hypertension - Importance of thyroid disease and function. Thromb Res. 2019 Oct 31; 185: 20-26. 75. Kuniss M, Akkaya E, Berkowitsch A, Zaltsberg S, Greiss H, Rechner M, Weipert K, Hain A, Hamm CW, Neumann T. Left atrial roof ablation in patients with persistent atrial fibrillation using the second-generation cryoballoon: benefit or wasted time? Clin Res Cardiol. 2019 Oct 30: In press. 76. Lanz J, Kim WK, Walther T, Burgdorf C, Möllmann H, Linke A, Redwood S, Thilo C, Hilker M, Joner M, Thiele H, Conzelmann L, Conradi L, Kerber S, Schymik G, Prendergast B, Husser O, Stortecky S, Heg D, Juni P, Windecker S, Pilgrim T. Safety and efficacy of a self-expanding ver- sus a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with symptomatic severe aortic stenosis: a randomised non-inferiority trial. Lancet. 2019 Nov 2; 394(10209): 1619-1628. 77. Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Calo L, Vicentini A, Con- cha JF, Thibault B. Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with MultiPoint Pacing (MORE- CRT MPP) study: results from Phase I. Eur Heart J. 2019 Mar 11; 40: 2979–2987. 78. Leclercq C, Burri H, Curnis A, Delnoy PP, Rinaldi CA, Sperzel J, Lee K, Cohorn C, Thibault B. Ra- tionale and design of a randomized clinical trial to assess the safety and efficacy of multipoint pacing therapy: MOre REsponse on Cardiac Resynchronization Therapy with MultiPoint Pacing (MORE-CRT MPP-PHASE II). Am Heart J. 2019 Mar; 209: 1-8. 79. Leonardi S, Franzone A, Piccolo R, McFadden E, Vranckx P, Serruys P, Benit E, Liebetrau C, Janssens L, Ferrario M, Zurakowski A, van Geuns RJ, Dominici M, Huber K, Slagboom T, Busz- man P, Bolognese L, Tumscitz C, Bryniarski K, Aminian A, Vrolix M, Petrov I, Garg S, Naber C, Prokopczuk J, Hamm C, Steg G, Heg D, Juni P, Windecker S, Valgimigli M. Rationale and design of a prospective substudy of clinical endpoint adjudication processes within an investigator- reported randomised controlled trial in patients with coronary artery disease: the GLOBAL LEADERS Adjudication Sub-StudY (GLASSY). BMJ Open. 2019 Mar 9; 9(3): e026053. 80. Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kramer-Albers EM, Liebetrau C, Wieden- roth CB, Mayer E, Kriechbaum SD, Dörr O, Nef H, Hamm CW, Keller T, Troidl C. Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA. Biomolecules. 2019 Oct 29; 9(11). 81. Mahendiran T, Nanchen D, Gencer B, Meier D, Klingenberg R, Raber L, Carballo D, Matter CM, Lüscher TF, Windecker S, Mach F, Rodondi N, Müller O, Fournier S. Prognosis of Patients with Chronic and Hospital-Acquired Anaemia After Acute Coronary Syndromes. J Cardiovasc Transl Res. 2019 Nov 25. 82. Möllmann H, Husser O, Blumenstein J, Liebetrau C, Dörr O, Kim WK, Nef H, Tesche C, Hamm CW, Elsässer A, Achenbach S, Gaede L. Lower mortality in an all-comers aortic stenosis popu- lation treated with TAVI in comparison to SAVR. Clin Res Cardiol. 2019 Oct 1: In press. 83. Most AK, Bauer T, Nef H, Hamm C, Bauer P. Malignant anomalous origin of circumflex artery in an elite athlete. Clin Res Cardiol. 2019 Jun; 108(6): 719-721. 84. Mutlak H, Assmus B, Popov AF. Minimally invasive embolectomy of HeartWare left ventricular assist device outflow graft. J Thorac Dis. 2019 Apr; 11(Suppl 6): S957-s959. 11
Kardiologie 85. Nanchen D, Klingenberg R, Gencer B, Raber L, Carballo D, von Eckardstein A, Windecker S, Ro- dondi N, Lüscher TF, Mach F, Muller O, Matter CM. Inflammation during acute coronary syn- dromes - Risk of cardiovascular events and bleeding. Int J Cardiol. 2019 Jul 15; 287: 13-18. 86. Nef HM, Wiebe J, Schmidt G, Möllmann H, Boeder NF, Dörr O, Bauer T, Blachutzik F, Liebetrau C, Elsässer A, Foin N, Hamm CW. Everolimus- vs. novolimus-eluting bioresorbable scaffolds in patients with acute coronary syndrome. Herz. 2019 June 17: In press. 87. Neumann JT, Sorensen NA, Rubsamen N, Ojeda F, Schafer S, Keller T, Blankenberg S, Clem- mensen P, Westermann D. Right bundle branch block in patients with suspected myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2019 Mar; 8(2): 161-166. 88. Neumann JT, Twerenbold R, Ojeda F, Sorensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Munzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jorgensen T, Soderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renne T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blank- enberg S. Application of High-Sensitivity Troponin in Suspected Myocardial Infarction. N Engl J Med. 2019 Jun 27; 380(26): 2529-2540. 89. Nunez-Gil IJ, Cerrato E, Bollati M, Nombela-Franco L, Terol B, Alfonso-Rodriguez E, Camacho Freire SJ, Villablanca PA, Amat Santos IJ, de la Torre Hernandez JM, Pascual I, Liebetrau C, Camacho B, Pavani M, Albistur J, Latini RA, Varbella F, Jimenez-Diaz VA, Piraino D, Mancone M, Alfonso F, Linares JA, Rodriguez-Olivares R, Jimenez Mazuecos JM, Palazuelos Molinero J, Sanchez-Grande Flecha A, Gomez-Hospital JA, Ielasi A, Lozano I, Omede P, Bagur R, Ugo F, Medda M, Louka BF, Kala P, Escaned J, Bautista D, Feltes G, Salinas P, Alkhouli M, Macaya C, Fernandez-Ortiz A. Coronary artery aneurysms, insights from the international coronary artery aneurysm registry (CAAR). Int J Cardiol. 2019 Jul 19: In press. 90. Ortmann CA, Dorsheimer L, Abou-El-Ardat K, Hoffrichter J, Assmus B, Bönig H, Scholz A, Pfeifer H, Martin H, Schmid T, Brune B, Scheich S, Steffen B, Riemann J, Hermann S, Dukat A, Bug G, Brandts CH, Wagner S, Serve H, Rieger MA. Functional Dominance of CHIP-Mutated Hemato- poietic Stem Cells in Patients Undergoing Autologous Transplantation. Cell Rep. 2019 May 14; 27(7): 2022-2028.e3. 91. Pagnesi M, Kim WK, Conradi L, Barbanti M, Stefanini GG, Zeus T, Pilgrim T, Schofer J, Zweiker D, Testa L, Taramasso M, Hildick-Smith D, Abizaid A, Wolf A, Van Mieghem NM, Sedaghat A, Wohrle J, Khogali S, Van der Heyden JAS, Webb JG, Estevez-Loureiro R, Mylotte D, MacCarthy P, Brugaletta S, Hamm CW, Bhadra OD, Schafer U, Costa G, Tamburino C, Cannata F, Reimers B, Veulemans V, Asami M, Windecker S, Eitan A, Schmidt A, Bianchi G, Bedogni F, Saccocci M, Maisano F, Alsanjari O, Siqueira D, Jensen CJ, Naber CK, Ziviello F, Sinning JM, Seeger J, Rott- bauer W, Brouwer J, Alenezi A, Wood DA, Tzalamouras V, Regueiro A, Colombo A, Latib A. Transcatheter Aortic Valve Replacement With Next-Generation Self-Expanding Devices: A Mul- ticenter, Retrospective, Propensity-Matched Comparison of Evolut PRO Versus Acurate neo Transcatheter Heart Valves. JACC Cardiovasc Interv. 2019 Mar 11; 12(5): 433-443. 92. Pellegrini C, Husser O, Kim WK, Holzamer A, Walther T, Rheude T, Mayr NP, Trenkwalder T, Joner M, Michel J, Chaustre F, Kastrati A, Schunkert H, Burgdorf C, Hilker M, Möllmann H, Heng- stenberg C. Predictors of Need for Permanent Pacemaker Implantation and Conduction Abnor- malities With a Novel Self-expanding Transcatheter Heart Valve. Rev Esp Cardiol (Engl Ed). 2019 Feb; 72(2): 145-153. 93. Pellegrini C, Kim WK, Holzamer A, Walther T, Mayr NP, Michel J, Rheude T, Nunez J, Kasel AM, Trenkwalder T, Kaess BM, Joner M, Kastrati A, Schunkert H, Hilker M, Möllmann H, Hengsten- berg C, Husser O. Multicenter Evaluation of Prosthesis Oversizing of the SAPIEN 3 Transcathe- ter Heart Valve. Impact on Device Failure and New Pacemaker Implantations. Rev Esp Cardiol (Engl Ed). 2019 Aug; 72(8): 641-648. 12
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Kardiologie 105. Schmitt J, Butter C. [Living with implanted cardiac devices]. Herzschrittmacherther Elektro- physiol. 2019 Jun; 30(2): 143. 106. Schulte C, Barwari T, Joshi A, Theofilatos K, Zampetaki A, Barallobre-Barreiro J, Singh B, Sorensen NA, Neumann JT, Zeller T, Westermann D, Blankenberg S, Marber M, Liebetrau C, Mayr M. Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury. Circ Res. 2019 Jul 19; 125(3): 328-340. 107. Schüpke S, Neumann FJ, Menichelli M, Mayer K, Bernlochner I, Wohrle J, Richardt G, Liebetrau C, Witzenbichler B, Antoniucci D, Akin I, Bott-Flugel L, Fischer M, Landmesser U, Katus HA, Sibbing D, Seyfarth M, Janisch M, Boncompagni D, Hilz R, Rottbauer W, Okrojek R, Möllmann H, Hochholzer W, Migliorini A, Cassese S, Mollo P, Xhepa E, Kufner S, Strehle A, Leggewie S, Allali A, Ndrepepa G, Schuhlen H, Angiolillo DJ, Hamm CW, Hapfelmeier A, Tolg R, Trenk D, Schunk- ert H, Laugwitz KL, Kastrati A. Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes. N Engl J Med. 2019 Oct 17; 381(16): 1524-1534. 108. Stähli BE, Wischnewsky MB, Jakob P, Klingenberg R, Obeid S, Heg D, Raber L, Windecker S, Mach F, Gencer B, Nanchen D, Juni P, Landmesser U, Matter CM, Lüscher TF, Maier W. Gender and age differences in outcomes of patients with acute coronary syndromes referred for coronary angiography. Catheter Cardiovasc Interv. 2019 Jan 1; 93(1): 16-24. 109. Sugiyama T, Yamamoto E, Fracassi F, Lee H, Yonetsu T, Kakuta T, Soeda T, Saito Y, Yan BP, Kurihara O, Takano M, Niccoli G, Crea F, Higuma T, Kimura S, Minami Y, Ako J, Adriaenssens T, Boeder NF, Nef HM, Fujimoto JG, Fuster V, Finn AV, Falk E, Jang IK. Calcified Plaques in Patients With Acute Coronary Syndromes. JACC Cardiovasc Interv. 2019 Mar 25; 12(6): 531-540. 110. Tesche C, Otani K, De Cecco CN, Coenen A, De Geer J, Kruk M, Kim YH, Albrecht MH, Baumann S, Renker M, Bayer RR, Duguay TM, Litwin SE, Varga-Szemes A, Steinberg DH, Yang DH, Kepka C, Persson A, Nieman K, Schoepf UJ. Influence of Coronary Calcium on Diagnostic Performance of Machine Learning CT-FFR: Results From MACHINE Registry. JACC Cardiovasc Imaging. 2019 Aug 8: In press. 111. Tzikas S, Vassilikos V, Keller T. GDF-15 as a risk stratification biomarker for cardiovascular disease. Int J Cardiol. 2019 Jun 8; 292: 246-247. 112. van den Bruck JH, Sultan A, Luker J, Thomas D, Willems S, Weinmann K, Kuniss M, Hochadel M, Senges J, Andresen D, Brachmann J, Kuck KH, Tilz R, Steven D. Remote vs. conventional navigation for catheter ablation of atrial fibrillation: insights from prospective registry data. Clin Res Cardiol. 2019 Mar; 108(3): 298-308. 113. Vogel J, Niederer D, Engeroff T, Vogt L, Troidl C, Schmitz-Rixen T, Banzer W, Troidl K. Effects on the Profile of Circulating miRNAs after Single Bouts of Resistance Training with and without Blood Flow Restriction-A Three-Arm, Randomized Crossover Trial. Int J Mol Sci. 2019 Jul 2; 20 (13): 3249. 114. von Jeinsen B, Liebetrau C, Palapies L, Tzikas S, Zeller T, Bickel C, Schmidt A, Tubaro M, Lackner KJ, Sar F, Baldus S, Zeiher AM, Blankenberg S, Gori T, Münzel T, Hamm CW, Wild PS, Keller T. Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds. Biomarkers. 2019 Sep; 24(6): 549-555. 115. von Jeinsen B, Sopova K, Palapies L, Leistner DM, Fichtlscherer S, Seeger FH, Honold J, Dimmeler S, Assmus B, Zeiher AM, Keller T. Bone marrow and plasma FGF-23 in heart failure patients: novel insights into the heart-bone axis. ESC Heart Fail. 2019 Mar 25; 6: 536-544. 116. Vuilleumier N, Pagano S, Combescure C, Gencer B, Virzi J, Raber L, Carballo D, Carballo S, Nanchen D, Rodondi N, Windecker S, Hazen SL, Wang Z, Li XS, von Eckardstein A, Matter CM, Lüscher TF, Klingenberg R, Mach F. Non-Linear Relationship between Anti-Apolipoprotein A-1 IgGs and Cardiovascular Outcomes in Patients with Acute Coronary Syndromes. J Clin Med. 2019 Jul 9; 8(7): E1002. 117. Weipert KF, Bauer T, Nef HM, Hochadel M, Weidinger F, Gitt AK, Zeymer U, Hamm CW. Incidence and outcome of peri-procedural cardiogenic shock: results from the international Euro Heart Survey PCI registry. Eur Heart J Acute Cardiovasc Care. 2019 Jan 8: In press. 118. Wernly B, Zappe AK, Unbehaun A, Sinning JM, Jung C, Kim WK, Fichtlscherer S, Lichtenauer M, Hoppe UC, Alushi B, Beckhoff F, Wewetzer C, Franz M, Kretzschmar D, Navarese E, Landmesser U, Falk V, Lauten A. Transcatheter valve-in-valve implantation (VinV-TAVR) for failed surgical aortic bioprosthetic valves. Clin Res Cardiol. 2019 Jan; 108(1): 83-92. 14
Kardiologie 119. Wichmann JL, Takx RAP, Nunez JH, Vliegenthart R, Otani K, Litwin SE, Morris PB, De Cecco CN, Rosenberg RD, Bayer RR, 2nd, Baumann S, Renker M, Vogl TJ, Wenger NK, Schoepf UJ. Relationship Between Pregnancy Complications and Subsequent Coronary Artery Disease Assessed by Coronary Computed Tomographic Angiography in Black Women. Circ Cardiovasc Imaging. 2019 Jul; 12(7): e008754. 120. Winzap P, Davies A, Klingenberg R, Obeid S, Roffi M, Mach F, Raber L, Windecker S, Templin C, Nietlispach F, Nanchen D, Gencer B, Muller O, Matter CM, von Eckardstein A, Lüscher TF. Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61. Cardiovasc Diabetol. 2019 Oct 31; 18(1): 142. 121. Yamamoto E, Yonetsu T, Kakuta T, Soeda T, Saito Y, Yan BP, Kurihara O, Takano M, Niccoli G, Higuma T, Kimura S, Minami Y, Ako J, Adriaenssens T, Boeder NF, Nef HM, Fracassi F, Sugiyama T, Lee H, Crea F, Kimura T, Fujimoto JG, Fuster V, Jang IK. Clinical and Laboratory Predictors for Plaque Erosion in Patients With Acute Coronary Syndromes. J Am Heart Assoc. 2019 Nov 5; 8 (21): e012322. 122. Yoon SH, Bleiziffer S, Latib A, Eschenbach L, Ancona M, Vincent F, Kim WK, Unbehaum A, Asami M, Dhoble A, Silaschi M, Frangieh AH, Veulemans V, Tang GHL, Kuwata S, Rampat R, Schmidt T, Patel AJ, Nicz PFG, Nombela-Franco L, Kini A, Kitamura M, Sharma R, Chakravarty T, Hildick-Smith D, Arnold M, de Brito FS, Jr., Jensen C, Jung C, Jilaihawi H, Smalling RW, Maisano F, Kasel AM, Treede H, Kempfert J, Pilgrim T, Kar S, Bapat V, Whisenant BK, Van Belle E, Delgado V, Modine T, Bax JJ, Makkar RR. Predictors of Left Ventricular Outflow Tract Obstruction After Transcatheter Mitral Valve Replacement. JACC Cardiovasc Interv. 2019 Jan 28; 12(2): 182-193. 123. Yoon SH, Whisenant BK, Bleiziffer S, Delgado V, Dhoble A, Schofer N, Eschenbach L, Bansal E, Murdoch DJ, Ancona M, Schmidt T, Yzeiraj E, Vincent F, Niikura H, Kim WK, Asami M, Unbehaun A, Hirji S, Fujita B, Silaschi M, Tang GHL, Kuwata S, Wong SC, Frangieh AH, Barker CM, Davies JE, Lauten A, Deuschl F, Nombela-Franco L, Rampat R, Nicz PFG, Masson JB, Wijeysundera HC, Sievert H, Blackman DJ, Gutierrez-Ibanes E, Sugiyama D, Chakravarty T, Hildick-Smith D, de Brito FS, Jr., Jensen C, Jung C, Smalling RW, Arnold M, Redwood S, Kasel AM, Maisano F, Treede H, Ensminger SM, Kar S, Kaneko T, Pilgrim T, Sorajja P, Van Belle E, Prendergast BD, Bapat V, Modine T, Schofer J, Frerker C, Kempfert J, Attizzani GF, Latib A, Schaefer U, Webb JG, Bax JJ, Makkar RR. Outcomes of transcatheter mitral valve replacement for degenerated bio prostheses, failed annuloplasty rings, and mitral annular calcification. Eur Heart J. 2019 Feb 1; 40 (5): 441-451. 124. Zhang D, Song X, Chen Y, Raposeiras-Roubin S, Abu-Assi E, Henriques JPS, D'Ascenzo F, Saucedo J, Gonzalez-Juanatey JR, Wilton SB, Kikkert WJ, Nunez-Gil I, Ariza-Sole A, Alexopou los D, Liebetrau C, Kawaji T, Moretti C, Huczek Z, Nie S, Fujii T, Correia L, Kawashiri MA, Garcia- Acuna JM, Southern D, Alfonso E, Terol B, Garay A, Xanthopoulou I, Osman N, Mollmann H, Shiomi H, Giordana F, Kowara M, Filipiak K, Wang X, Yan Y, Fan J, Ikari Y, Nakahashi T, Sakata K, Yamagishi M, Kalpak O, Kedev S. Outcome of Patients With Prior Stroke/Transient Ischemic Attack and Acute Coronary Syndromes. Angiology. 2019 Dec 3: 3319719889524. 125. Zschirnt M, Jux C, Boenig H, Zeiher A, Assmus B, Khalil M, Kriebel T, Rupp S. Neonatal myocardial infarction: substantial improvement of cardiac function after autologous bone marrow-derived cell therapy. Clin Res Cardiol. 2019 Apr 26; 108(11): 1309-1311. 15
Kardiologie Buchartikel 1. Aslam M and Haider KH. Adrenomedullins and their emerging role in regenerative medicine. In: Stem Cells – From Myth to Reality. Haider KH (Ed.), 1st edition pp 145 – 165, DE GRUYTER, 2019 2. Giannitsis E, Hamm C, Nef H, Katus HA. The PCR – EAPCI Textbook: Percutaneous Intervention- al Cardiovascular Medicine. Vol. I, Part II: Cardiac Biomarkers. William Wijns, Patrick W. Serruys, Alec Vahanian, Eric Eeckhout, Rodney De Palma, Marc van Sambeek (Eds.) PCR ONLINE, up- date 2019. 3. Möllmann H, Nef HM, Blumenstein J, Hamm CW. The PCR – EAPCI Textbook: Percutaneous Interventional Cardiovascular Medicine. Vol. I, Part III: Interventions for non-ST-segment eleva- tion acute coronary syndromes. William Wijns, Patrick W. Serruys, Alec Vahanian, Eric Eeck- hout, Rodney De Palma, Marc van Sambeek (Eds.) PCR ONLINE, update 2019. Buch 1. Florian Blachutzik. OCT-Kompendium 2. Auflage; Abbott, 2019 Preise und Ehrungen 1. Goldene Ehrennadel der Deutschen Gesellschaft für Kardiologie, 23.05.2019 Prof. Dr. med. Christian W. Hamm 2. Deutsche Gesellschaft für Kardiologie, Young Investigator Award – Herzinsuffizienz 2. Platz: Dr. med. Stanislav Keranov et al. (S. Keranov, O. Dörr, J. Lorenz, L. Jafari, C. Liebetrau, S. Kriechbaum, T. Keller, C. Troidl, S. Voß, T. Bauer, M. J. Richter, K. Tello, H. Gall, H. Ghofrani, E. Mayer, T. Braun, W. Seeger, C. W. Hamm, H. Nef. Evaluation von Cartilage intermediate layer protein 1 (CILP1) als Biomarker für Myokardfibrose und maladaptives rechtsventrikuläres Remodeling) 3. Publikationspreis des Vereins der Freunde und Förderer der Kerckhoff-Klinik 3. Platz: Dr. med. Won-Keun Kim et al. (Kim WK, Liebetrau C, Fischer-Rasokat U, Renker M, Rolf A, Doss M, Möllmann H, Nef H, Walther T, Hamm CW. Challenges of recognizing bicuspid aortic valve in elderly patients undergoing TAVR. Int J Cardiovasc Imaging. 2019 Oct 5: In press.) 4. AGIK Publikationspreis der Deutschen Gesellschaft für Kardiologie 3. Platz: Dr. med. Won-Keun Kim et al. (Kim WK, Schafer U, Tchetche D, Nef H, Arnold M, Avanzas P, Rudolph T, Scholtz S, Barbanti M, Kempfert J, Mangieri A, Lauten A, Frerker C, Yoon SH, Holza- mer A, Praz F, De Backer O, Toggweiler S, Blumenstein J, Purita P, Tarantini G, Thilo C, Wolf A, Hus- ser O, Pellegrini C, Burgdorf C, Antolin RAH, Diaz VAJ, Liebetrau C, Schofer N, Möllmann H, Egge- brecht H, Sondergaard L, Walther T, Pilgrim T, Hilker M, Makkar R, Unbehaun A, Borgermann J, Moris C, Achenbach S, Dörr O, Brochado B, Conradi L, Hamm CW. Incidence and outcome of peri- procedural transcatheter heart valve embolization and migration: the TRAVEL registry (TranscatheteR HeArt Valve EmboLization and Migration). Eur Heart J. 2019 Jun 23; 40(38): 3156- 3165. 16
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Herzzentrum Herzchirurgie Komm. Direktor: Prof. Dr. med. M. Schönburg 19
Herzchirurgie PUBLIKATIONEN 2019 Originalarbeiten & Übersichtsartikel 1. Long-term outcome after mitral valve replacement using biological versus mechanical valves. Cetinkaya A, Poggenpohl J, Bramlage K, Hein S, Doss M, Bramlage P, Schönburg M, Richter J Cardiothorac Surg. 2019 Jun 28;14(1):120. doi: 10.1186/s13019-019-0943-6.J Cardiothorac Surg. 2019. PMID: 31253187 Free PMC article. 2. Interactions between rheumatoid arthritis synovial fibroblast migration and endothelial cells. Zimmermann-Geller B, Köppert S, Kesel N, Hasseli R, Ullrich S, Lefèvre S, Frommer K, Gehrke T, Schönburg M, Rehart S, Schumacher U, Müller-Ladner U, Neumann Immunol Cell Biol. 2019 Feb;97(2):178-189. doi: 10.1111/imcb.12208. Epub 2018 Nov 2. 3. Animal Models and "Omics" Technologies for Identification of Novel Biomarkers and Drug Targets to Prevent Heart Failure. Hou Y, Adrian-Segarra JM, Richter M, Kubin N, Shin J, Werner I, Walther T, Schönburg M, Pöling J, Warnecke H, Braun T, Kostin S, Kubin T. Biomed Res Int. 2015;2015:212910. doi: 10.1155/2015/212910. Epub 2015 Jul 7. 4. Atresia of the inferior vena cava in a patient undergoing mitral and tricuspid valve surgery. Cetinkaya A, Bramlage P, Schönburg M, Richter Interact Cardiovasc Thorac Surg. 2019 Feb 1;28 (2):324-326. doi: 10.1093/icvts/ivy240.Interact Cardiovasc Thorac Surg. 2019. PMID: 30084986 5. Decreasing postoperative cognitive deficits after heart surgery: protocol for a randomized controlled trial on cognitive training. Butz M, El Shazly J, Sammer G, Tschernatsch M, Kastaun S, Yenigün M, Braun T, Kaps M, Böning A, Puvogel U, Bachmann G, Mengden T, Schönburg M, Gerriets T, Juenemann M. Trials. 2019 Dec 16;20(1):733. doi: 10.1186/s13063-019-3799-0. 6. 1-Year Survival After TAVR of Patients With Low-Flow, Low-Gradient and High-Gradient Aortic Valve Stenosis in Matched Study Populations. Fischer-Rasokat U, Renker M, Liebetrau C, van Linden A, Arsalan M, Weferling M, Rolf A, Doss M, Möllmann H, Walther T, Hamm CW, Kim WK. JACC Cardiovasc Interv. 2019 Apr 22;12(8):752-763. doi: 10.1016/j.jcin.2019.01.233. 7. Challenges of recognizing bicuspid aortic valve in elderly patients undergoing TAVR. Kim WK, Liebetrau C, Fischer-Rasokat U, Renker M, Rolf A, Doss M, Möllmann H, Nef H, Walther T, Hamm CW. Int J Cardiovasc Imaging. 2019 Oct 5. 8. Annular versus supra-annular sizing for TAVI in bicuspid aortic valve stenosis. Kim WK, Renker M, Rolf A, Fischer-Rasokat U, Wiedemeyer J, Doss M, Möllmann H, Walther T, Nef H, Hamm CW, Liebetrau C. EuroIntervention. 2019 Jun 12;15(3):e231-e238. doi: 10.4244/EIJ-D-19-00236. 9. 1-Year Survival After TAVR of Patients With Low-Flow, Low-Gradient and High-Gradient Aortic Valve Stenosis in Matched Study Populations. Fischer-Rasokat U, Renker M, Liebetrau C, van Linden A, Arsalan M, Weferling M, Rolf A, Doss M, Möllmann H, Walther T, Hamm CW, Kim WK. JACC Cardiovasc Interv. 2019 Apr 22;12(8):752-763. doi: 10.1016/j.jcin.2019.01.233. 10. Transfemoral implantation of the ACURATE neo prosthesis using a low-profile expandable introducer system: A multicenter registry. Kim WK, Brinkert M, Mangner N, Gatto F, Husser O, Renker M, Liebetrau C, Gasior T, Doss M, Walther T, Hamm C, Linke A, Toggweiler S, Möllmann Int J Cardiol. 2019 Apr 15;281:76-81. doi: 10.1016/j.ijcard.2019.01.081. Epub 2019 Jan 25. 11. Outcome of patients with heart failure after transcatheter aortic valve implantation. Fischer-Rasokat U, Renker M, Liebetrau C, Weferling M, Rolf A, Doss M, Möllmann H, Walther T, Hamm CW, Kim WK.Fischer-Rasokat U, et al. PLoS One. 2019 Nov 26;14(11):e0225473. doi: 10.1371/journal.pone.0225473. eCollection 2019. 12. The Bridge Occlusion Balloon for Venous Angioplasty in Superior Vena Cava Occlusion. Pecha S, Burger H, Castro L, Gosau N, Atlihan G, Willems S, Reichenspurner H, Hakmi S. Braz. J Cardiovasc Surg, 34(3):368-371, 2019 13. The German Laser Lead Extraction Registry: GALLERY. Pecha S, Burger H, Möller V. Thorac Cardiovasc Surg 67(S 01):S1-S100, 2019 20
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Rheumazentrum Rheumatologie & Klinische Immunologie Direktor: Univ.- Prof. Dr. med. U. Müller-Ladner Physikalische Medizin & Osteologie Direktor: Univ.- Prof. Dr. med. U. Lange 23
Rheumazentrum Publikationsbericht 2019 Rheumatologie & klinische Immunologie Physikalische Medizin & Osteologie Originalarbeiten & Übersichtsartikel 1. Becker M, Graf N, Sauter R, Allanore Y, Curram J, Denton CP, Khanna D, Matucci-Cerinic M, de Oliveira Pena J, Pope JE, Distler O, and EUSTAR Collaborators (…Müller-Ladner U…). Predictors of disease worsening defined by progression of organ damage in diffuse systemic sclerosis: a Eu- ropean Scleroderma Trials and Research (EUSTAR) analysis. Ann Rheum Dis 2019;78:1242-1248 2. Belz D, Moinzadeh P, Riemekasten G, Henes J, Müller-Ladner U, Blank N, Koetter I, Siegert E, Pfeiffer C, Schmalzing M, Zeidler G, Schmeiser T, Worm M, Guenther C, Susok L, Kreuter A, Sun- derkoetter C, Juche A, Aberer E, Gaebelein-Wissing N, Ramming A, Kuhr K, Hunzelmann N. Large variability of frequency and type of physical therapy in patients of the German Network for Systemic Sclerosis. Arthritis Care Res 2019 (Epub ahead of print) 3. Blagojevic J, Bellando-Randone S, Abignano G, Avouac J, Cometi L, Czirják L, Denton CP, Distler O, Frerix M, Guiducci S, Huscher D, Jaeger VK, Lóránd V, Maurer B, Nihtyanova S, Riemekasten G, Siegert E, Tarner IH, Vettori S, Walker UA, Allanore Y, Müller-Ladner U, Del Galdo F, Matucci- Cerinic M; EUSTAR co-workers. Classification, categorization and essential items for digital ulcer evaluation in systemic sclerosis: a DeSScipher/European Scleroderma Trials and Research group (EUSTAR) survey. Arthritis Res Ther 2019;21:35 4. Burmester G, Nüsslein H, von Hinüber U, Detert J, Richter C, Kumke T, Leunikava I, Lendl U, Fricke D, Müller-Ladner U. Effectiveness and Safety of Anti-TNFα Therapy with Certolizumab Pegol Observed in Real-life Rheumatoid Arthritis Patients in Germany: Results from the Non- Interventional FαsT Study. Clin Exp Rheum 2019;37:842-851 5. Carrión M, Frommer KW, Pérez-García S, Müller-Ladner U, Gomariz RP, Neumann E. The Adi- pokine Network in Rheumatic Joint Diseases. Int J Mol Sci 2019;20:4091 6. Decker E, Basten O, Librizzi D, Müller-Ladner U. Hand ischemia and increased CRP level in a 75- year-old female patient. Z Rheumatol 2019 (Epub ahead of print) 7. Diller M, Hasseli R, Hülser M-L, Aykara I, Frommer K, Rehart S, Müller-Ladner U, Neumann E. Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib. Front Immunol 2019;10:541 8. Diller M, Frommer K, Dankbar B, Tarner I, Hülser M-L, Tsiklauri L, Hasseli R, Sauerbier M, Pap T, Rehart S, Müller-Ladner U, Neumann E. The activin-follistatin anti-inflammatory cycle is dereg- ulated in synovial fibroblasts. Arthritis Res Ther 2019;21:144 9. Dischereit G, Goronzy JE, Müller-Ladner U, Fetaj S, Lange U. Wirkeffekte serieller Heiltorfbäder bei entzündlich-rheumatischen und degenerativen Erkrankungen. Z Rheumatol 2019;78:1433- 154 10. Dischereit G, Lange U, Thiele A, Schmeiser T. Pneumocyctis jirovecii pneumonia with inflamma- tory rheumatic systemic diseases under immmunosuppressive therapy: Casuistics and review. Int J Clin Rheumatol 2019;14(5):200-212 11. Dischereit G, Lange U. Physikalische Therapie in der Rehabilitation entzündlich-rheumatischer Erkrankungen. Akt Rheumatol 2019;44:415-419 12. Dischereit, Klemm, Lange. Rheuma und Knochenstoffwechsel. Der Orthopäde 2019;48:911-916 13. Distler O, Maurer B, Avouac J, Tarner IH, Frerix M, Riemekasten G, Siegert E, Czirják L, Lóránd V, Denton CP, Nihtyanova S, Walker UA, Jaeger VK, Del Galdo F, Abignano G, Ananieva LP, Gher- ghe AM, Mihai C, Henes JC, Schmeiser T, Vacca A, Moiseev S, Foeldvari I, Gabrielli A, Krummel- Lorenz B, Rednic S, Allanore Y, Müller-Ladner U. Vasodilators and low-dose acetylsalicylic acid are associated with a lower incidence of distinct primary myocardial disease manifestations in systemic sclerosis: results of the DeSScipher inception cohort study. Ann Rheum Dis 2019;78:1576-1582 24
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