Respiration International Journal of Thoracic Medicine - Karger Publishers
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Respiration
International Journal of
Thoracic Medicine
EABIP
OFEV®
(Nintedanib)
WIRKT RISIKO LANGZEIT- EINFACH
DATEN
der jährlichen Risikoreduktion bei bestätigen die Einfache Einnahme
Abnahme der adjudizierten*, akuten Resultate aus den 1 Kapsel
Lungenfunktion Exazerbationen Zulassungsstudien 2x täglich1,2
(FVC -49%)1,2 bei (-68%)1,2 sowie und zeigen keine
einem breiten on-treatment neuen sicherheits-
Patientenspektrum3-5 Mortalität (-43%)6 relevanten Aspekte
entgegen gepoolte Daten aus 3 Studien (n= 734, Median 44,7
(HR 0.57 [95% CI: 0.34, 0.97]; Monate, 11,9-68,3)7
p=0.0274)
*) Bewertung durch ein unabhängiges Expertengremium
1.) OFEV® Fachinformation, www.swissmedicinfo.ch 2.) Richeldi L et al. Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis. NEJM 2014; 370:2071-2082 3.) Kolb M. et al.
Nintedanib in patients with idiopathic pulmonary fibrosis and preserved lung volume. Thorax 2016; 0:1-7 4.) Raghu G et al. Effects of Nintedanib in Subgroups of Idiopathic Pulmonary
Fibrosis by Diagnostic Criteria. Am J Respir Crit Care Med. 2017;195:78-85 5.) Cottin V et al.Therapeutic effects of nintedanib are not influenced by emphysema in the INPULSIS trials.
ERS 2019 6.) Richeldi L et al. Nintedanib in patients with idiopathic pulmonary fibrosis: Combined evidence from the TOMORROW and INPULSIS® trials. Resp Med 113 (2016) 74-79
7.) Crestani B et al. Long-term safety and tolerability of nintedanib in patients with idiopathic pulmonary fibrosis: results from the open-label extension study INPULSIS-ON. Lancet
Respir Med. 2018;doii:10.1016/S2213-2600(18)30339-4
Ofev®: Nintedanibesilat (Tyrosinkinaseinhibitor). I: Behandlung der idiopathischen Lungenfibrose (IPF) und Verlangsamung des Krankheitsverlaufes. D: Empfohlene Dosis: 150 mg 2x
pro Tag im Abstand von etwa 12 Stunden. KI: Schwangerschaft, Überempfindlichkeit gegen Nintedanib oder einen der sonstigen Bestandteile, Erdnüsse, Soja. VM: Eingeschränkte
Leberfunktion, Child-Pugh B,C: Anwendung nicht empfohlen. Child-Pugh A: Empfohlene Dosis 100 mg 2x pro Tag. Es wurden nicht-schwerwiegende und schwerwiegende (auch fatale)
arzneimittelinduzierte Leberschäden beobachtet. Hepatische Transaminasen, Bilirubinwerte zu Beginn und regelmässig in den ersten drei Monaten und danach periodisch kontrollieren.
Falls trotz symptomatischer Therapie von Diarrhö, Übelkeit, Erbrechen keine Besserung eintritt oder bei Transaminasenanstieg auf das 3-fache der Obergrenze des Normbereiches,
sollte die Dosis auf 100 mg 2x pro Tag reduziert oder die Behandlung abgebrochen werden. Endgültiges Absetzen der Behandlung bei klinischen Zeichen einer Leberschädigung
(Gelbsucht) oder bei Transaminasenanstieg > 5-fache Obergrenze des Normbereichs. Diarrhö und Erbrechen kann zur Dehydrierung mit oder ohne Elektrolytstörungen führen. Fälle
D-012020-PC-CH-100948 Respiratory OFEV
von Nierenfunktionsstörungen bzw. Nierenversagen, auch fatale, wurden berichtet. Patienten mit Risikofaktoren für Nierenfunktionsstörungen sollten überwacht werden. Anpassung
der Therapie bei Nierenfunktionsstörung. Bei Patienten mit Antikoagulation, erhöhtem kardiovaskulären Risiko, Hypertonie oder Aneurysmen in der Vorgeschichte, arteriellen
thromboembolischen Ereignissen, venöser Thromboembolie und Wundheilungsstörungen sollte Nintedanib mit Vorsicht angewendet werden. Fälle von schwerwiegenden und tödlichen
Blutungen (Patienten mit/ohne Antikoagulanzien oder anderen Arzneimitteln, die Blutungen hervorrufen könnten) und Fälle von gastrointestinalen, auch tödlichen Perforationen,
wurden berichtet. Bei Patienten mit kürzlichem bauchchirurgischem Eingriff, kürzlich aufgetretener Perforation eines Hohlorgans, peptischen Ulzera in der Anamnese, Divertikulose
oder einer begleitenden Anwendung von Corticosteroiden oder NSAR ist besondere Vorsicht geboten. Endgültiges Absetzen der Behandlung bei Auftreten einer gastrointestinalen
Perforation. Bei Befunden oder Symptomen einer akuten Myokardischämie ist eine Unterbrechung der Behandlung in Betracht zu ziehen. S: Nintedanib in der Schwangerschaft nicht
anwenden, Stillen unterbrechen. Adäquate Kontrazeption UW: Sehr häufig: Diarrhö, Übelkeit, Abdominalschmerz, erhöhte Leberenzyme. Häufig: Appetitverlust, Gewichtsverlust,
Erbrechen, Blutungen (Hämatochezie, Nasenbluten, Bluterguss; tödliche Ereignisse: gastrointestinale, intrakranielle, pulmonale Blutungen, DIC), erhöhte Leberenzymwerte (ALT, AST,
GGT), Hautausschlag. Gelegentlich: Hypertonie (inkl. hypertensive Krise und hypertensive Kardiomyopathie), Thrombozytopenie, Erhöhung der Alkalischen Phosphatase im Blut,
Hyperbilirubinämie, arzneimittelbedingter Leberschaden, Pankreatitis, gastrointestinale Perforation, Colitis, Pruritus IA: Starke P-gp-Inhibitoren (Ketoconazol, Erythromycin) können
die Nintedanib-Exposition erhöhen. Starke P-gp-Induktoren (Rifampicin, Carbamazepin, Phenytoin, Johanniskraut) können die Nintedanib-Exposition verringern. Die Nintedanib-
Exposition nahm unter Pirfenidon ab, Nintedanib beeinflusste nichte die Pirfenidon-Exposition. Nintedanib mit Nahrung einnehmen. P: Kapseln zu 100mg und 150mg: 60. Liste B.
Kassenzulässig. Stand der Information: Oktober 2019; vollständige Fachinformation auf www.swissmedicinfo.ch. Boehringer Ingelheim (Schweiz) GmbH, Hochbergerstrasse 60B,
Postfach, 4002 Basel.
Boehringer Ingelheim (Schweiz) GmbH
F20504
Hochbergerstrasse 60B, CH-4002 Basel, Telefon 061 295 25 25
MEDinfoIPF.BAS@boehringer-ingelheim.ch
Official Journal of
Respiration
International Journal of Thoracic Medicine
Founded 1944 as “Schweizerische Zeitschrift für Tuberkulose und
EABIP Pneumonologie” by E. Bachmann, M. Gilbert, F. Häberlin, W. Löffler,
P. Steiner and E. Uehlinger, continued 1962–1967 as “Medicina Thoracalis”,
as of 1968 as “Respiration”, H. Herzog (1962–1997), C.T. Bolliger (1998–2012)
Editor-in-Chief
Felix J.F. Herth – Universitätsklinikum Heidelberg, Heidelberg, Germany
Associate Editors
Konrad E. Bloch – Universitätsspital Zürich, Zurich, Switzerland
Annette Boehler – Universitätsspital Zürich, Zurich, Switzerland
Demosthenes Bouros – University of Athens, Athens, Greece
Alfredo Chetta – Università degli Studi di Parma, Parma, Italy
Vincent Cottin – Hôpital Louis Pradel, Lyon, France
Christophe Dooms – University Hospitals Leuven, Leuven, Belgium
Ernst Eber – Medical University of Graz, Graz, Austria
Stefano Gasparini – Ospedale Torrette, Ancona, Italy
Jürg Hammer – University Children’s Hospital Basel, Basel, Switzerland
Coenraad F. Koegelenberg – University of Stellenbosch, Tygerberg Cape Town,
South Africa
Christoph Lange – German Center for Infection, Borstel, Germany
Marek Lommatsch – Universität Rostock, Rostock, Germany
Marc Miravitlles – Hospital Universitari Vall d’Hebron, Barcelona, Spain
Joachim Müller-Quernheim – Universitätsklinikum Freiburg, Freiburg, Germany
Laurent P. Nicod – Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Dario Olivieri – University of Parma, Parma, Italy
Venerino Poletti – Ospedale G.B. Morgagni, Forlì, Italy
Winfried J. Randerath – Krankenhaus Bethanien, Solingen, Germany
Otto D. Schoch – Kantonsspital St. Gallen, St. Gallen, Switzerland
Esther Irene Schwarz – Sleep Disorders Centre at Guy’s & St Thomas’ NHS Foundation
Trust, London, UK
Pallav L. Shah – Imperial College London, London, UK
Dirk-Jan Slebos – University Medical Center, Groningen, The Netherlands
Silvia Ulrich – Universitätsspital Zürich, Zurich, Switzerland
Omar S. Usmani – National Heart and Lung Institute & Royal Brompton Hospital,
London, UK
Stephan F. van Eeden – University of British Columbia, Vancouver, BC, Canada
Lowie Vanfleteren – Gothenburg University, Gothenburg, Sweden
Kazuhiro Yasufuku – University of Toronto, Toronto, ON, Canada
(Continued on next page)
Printed in Switzerland on acid-free and non-aging paper
(ISO 9706) by Werner Druck & Medien AG, Basel
(Continued)
Editorial Board Members
Xavier Basagne Flores – Centre for Research in Environmental Epidemiology, Barcelona,
Spain (Statistical Consultant)
Semra Bilaceroglu – Izmir Training and Research Hospital for Thoracic Medicine and
Surgery, Izmir, Turkey
Ivan Caviedes – Clínica Alemana de Santiago, Santiago, Chile
Mario Cazzola – University of Rome, Rome, Italy
Prashant N. Chhajed – Institute of Pulmonology Mumbai, Mumbai, India
Ulrich Costabel – Ruhrlandklinik, Essen, Germany
Claudia Crimi – Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele
di Catania, Catania, Italy
Jonne Doorduin – Radboud University Med. Center, Nijmegen, The Netherlands
Herve Dutau – Hôpital Nord, Marseille, France
Sebastian Fernandez-Bussy – Clinica Alemana de Santiago, Vitacura,
Santiago de Chile, Chile
Marios E. Froudarakis – University Hospital of Alexandroupolis, Alexandroupolis, Greece
Gerhard Hoheisel – Praxis für Pneumologie und Allergologie, Leipzig, Germany
Marc Humbert – Université Paris-Sud 11, Clamart, France
Gabriel Izbicki – Shaare Zedek Medical Center, Jerusalem, Israel
Michael Kreuter – University of Heidelberg, Heidelberg, Germany
Shiyue Li – Guangzhou Institute of Respiratory Diseases, Guangzhou, China
Weimin Li – West China Hospital of Sichuan University, Chengdu, China
Andrew R.L. Medford – University of Bristol, Bristol, UK
Najib Rahman – Oxford Centre for Respiratory Medicine, Oxford, United Kingdom
Claudia Ravaglia – Ospedale G.B. Morgagni, Forlì, Italy
Raffaele Scala – Azienda Usl Toscana sud est, P.O. San Donato, Arezzo, Italy
Frank C. Sciurba – University of Pittsburgh, Pittsburg, PA, USA
Grigoris Stratakos – University of Athens, Athens, Greece
Jiayuan Sun – Shanghai Jiao Tong University, Shanghai, China
Nakajiama Takahiro – Chiba University, Chiba, Japan
Sara Tomassetti – Azienda Ospedaliero Universitaria Careggi, Florence, Italy
Adriano Vaghi – ASST Rhodense P.O. di Garbagnate Milanese, Milan, Italy
Claudia Valenzuela – Hospital Universitario de la Princesa, Madrid, Spain
Arschang Valipour – Otto-Wagner-Hospital, Vienna, Austria
Erik van der Heijden – Radboud University Medical Center, Nijmegen, The Netherlands
Chen Wang – China-Japan Friendship Hospital, Beijing, China
Hubert Wirtz – Universität Leipzig, Leipzig, Germany
Emiel F.M. Wouters – University Hospital Maastricht, Maastricht, The Netherlands
© 2020 S. Karger AG, Basel
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karger@karger.com
Journal Information
Aims and Scope
Respiration brings together the results of both clinical and experimental investigations on all
aspects of the respiratory system in health and disease. Clinical improvements in the diag-
nosis and treatment of chest and lung diseases are covered, as are the latest findings in
physiology, biochemistry, pathology, immunology and pharmacology. The journal includes
classic features such as editorials that accompany original articles in clinical and basic science
Guidelines for Authors research, reviews and letters to the editor. Further sections are: The Eye Catcher, What’s Your
We strongly encourage authors to read
the Guidelines for Authors at
Diagnosis?, New Insights from Clinical Practice, and Guidelines.
www.karger.com/res_guidelines prior to Respiration is the official journal of the Swiss Respiratory Society (SGP) and also home to the
submitting an article. European Association for Bronchology and Interventional Pulmonology (EABIP), which oc-
cupies a dedicated section on Interventional Pulmonology in the journal. This modern mix
of different features and a stringent peer-review process by a dedicated editorial board make
Respiration a complete guide to progress in thoracic medicine.
Journal Contact
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Vol. 99, No. 9, 2020
Contents
Clinical Investigations
739 Factors Associated with a Positive Severe Acute Respiratory Syndrome Coronavirus 2
Testing in Suspected Cases Presenting with Pneumonia: A Retrospective Cohort
Study in a Single Medical Center
Li, Y.; Shang, Y.; Yang, Y.; Wang, M.; Yu, D.; Su, D.; Liu, L.; Wang, Q.; Zhang, X.; Ren, J.; Chen, H. (Harbin)
748 Chest Computed Tomography Findings in Asymptomatic Patients with COVID-19
Chang, M.C.; Lee, W.; Hur, J. (Daegu); Park, D. (Ulsan)
755 Characteristics of Pulmonary Auscultation in Patients with 2019 Novel Coronavirus in
China
Wang, B.; Liu, Y.; Wang, Y.; Yin, W. (Chengdu); Liu, T. (Wuhan); Liu, D.; Li, D.; Feng, M.; Zhang, Y.;
Liang, Z. (Chengdu); Fu, Z. (Guangyuan); Fu, S.; Li, W.; Xiong, N.; Wang, G.; Luo, F. (Chengdu)
764 Tobacco Use, Knowledge about Smoking-Associated Risks, and Cessation Programs
among Dental Students in Germany – ToDent
Bauer-Kemeny, C. (Heidelberg); Lis, IV. (Heidelberg/Bruchsal); Raupach, T. (Göttingen); Kreuter, M.
(Heidelberg)
771 Evaluation of the Physiological Changes in the Central Airway on Multi-Detector
Computed Tomography
Li, Y.; Li, L.; Zhou, Z.; Ren, K.; Lu, H.; Wang, X.; Li, Z.; Ren, J.; Han, X.; Li, Q. (Zhengzhou)
Interventional Pulmonology
779 Endobronchial Ultrasound Elastography for Differentiating Benign and Malignant
Lymph Nodes
Gompelmann, D. (Heidelberg/Vienna); Kontogianni, K.; Sarmand, N.; Kaukel, P.; Krisam, J.;
Eberhardt, R.; Herth, F.J.F. (Heidelberg)
784 Cryotherapy in Semirigid Thoracoscopy for Debridement of Multiloculated Empyema
Zhang, Q.; Wang, X.; Hu, Y.; Guo, F.-F.; Yu, K.-Y.; Wang, G.-F. (Beijing)
789 Local Anesthesia Thoracoscopy with versus without Midazolam:
A Randomized Controlled Trial
Koulelidis, A.; Anevlavis, S.; Nikitidis, N. (Alexandroupolis); Pappas, P. (Ioannina); Ntolios, P.
(Alexandroupolis); Karkabounas, A.; Boti, V. (Ioannina); Steiropoulos, P. (Alexandroupolis);
Karpathiou, G. (Saint-Priest-en-Jarez); Eleftheriadis, S.; Froudarakis, M.E. (Alexandroupolis)
Review
800 Material and Technology: Back to the Future for the Choice of Interface for
Non-Invasive Ventilation – A Concise Review
Scala, R. (Arezzo); Accurso, G.; Ippolito, M.; Cortegiani, A.; Iozzo, P.; Vitale, F. (Palermo); Guidelli, L.
(Arezzo); Gregoretti, C. (Palermo/Cefalù)
818 Erratum
Cover illustration
© 123rf.com
© 2020 S. Karger AG, Basel
Access to full text and tables of contents,
including tentative ones for forthcoming issues:
www.karger.com/res
Fasenra® ist angezeigt als Add-on-Erhaltungstherapie bei erwachsenen Patienten mit schwerem eosinophilem Asthma,
das trotz hochdosierter inhalativer Kortikosteroide plus lang wirksamer Beta-Agonisten unzureichend kontrolliert ist1
FASENRA® ZIELT AUF DIE NULL
0 Eosinophile
2,3
74 % hatten 0 Exazerbationen
* ,4
52 % hatten 0 orale Kortikosteroide
5
Patientenservice
Referenzen: * Patienten aus Vorläuferstudien (SIROCCO und CALIMA), die während des 56-wöchigen Beurteilungszeitraums die Q8W-Dosierung fortsetzten.1. Fachinformation, www.swissmedic.ch. 2. Nair P et al. Oral glucocorticoid-sparing effect of benralizumab
in severe asthma. N Engl J Med 2017; Supplementary Appendix. 3. Tan L et al. Benralizumab: a unique IL-5 inhibitor for severe asthma. J Asthma Allergy 2016; 9: Efficacy and steroid-sparing effect of benralizumab: has it an advantage over its competitors: 71–81.
4. Busse WW et al. Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial. Lancet Respir Med 2019; 7(1): 46–59. 5. Nair P et al. Oral glucocorticoid-sparing effect of
benralizumab in severe asthma. N Engl J Med 2017; 376: 2448–2458.
Fasenra®, Injektionslösung zur subkutanen Verabreichung Z: Benralizumab, 1 ml à 30 mg; Liste B. I: Zusatz zur Erhaltungstherapie bei erwachsenen Patienten ab 18 Jahren mit schwerem eosinophilem Asthma, welches durch folgende Kriterien gekennzeichnet ist:
CH-2897_08/2020
mindestens zwei Exazerbationen in den vorausgegangenen 12 Monaten unter aktueller Standardtherapie (hochdosierte inhalative Kortikosteroide plus langwirksame Bronchodilatatoren) und/oder Notwendigkeit zur Behandlung mit systemischen Kortikosteroiden;
F20525
Eosinophilenzahl im Blut von ≥ 0,3 G/Liter (entspricht ≥ 300 Zellen/μL). D: 30 mg subkutan alle 4 Wochen, ab Woche 8: 30 mg subkutan alle 8 Wochen. KI: Überempfindlichkeit. V: akute Asthma-Exazerbationen, abruptes Absetzen von
Kortikosteroiden nicht empfohlen, Patienten mit Helminthenbefall sollten entsprechend vorbehandelt sein. IA: keine. UAW: häufig: Kopfschmerzen, Pharyngitis, Fieber, Reaktionen an der Injektionsstelle, Überempfindlichkeitsreaktionen.
Gelegentlich, selten, sehr selten: siehe www.swissmedicinfo.ch. Stand der Information: April 2020. Weitere Informationen: www.swissmedicinfo.ch oder AstraZeneca AG, Neuhofstrasse 34, 6340 Baar. www.astrazeneca.ch.know what
matters in
Pneumology
karger.com/pneumology
KI20167_pneu_280Innovative coverage of recent advances in
translational medical research
Exploring the Basis of Disease
Editor-in-Chief Regional Editor: Far East
B. Borisch, Geneva H. Yokozaki, Kobe
s
re e acces
F r
f te r 1 yea
a
Pathobiology offers a valuable platform for the publication of high- Selected contributions
quality original research into the mechanisms underlying human dis- • Metabolomics Biomarkers for Breast Cancer: Günther, U.L. (Birmingham)
ease. Aiming to serve as a bridge between basic biomedical research • Gaucher Disease: Clinical, Biological and Therapeutic Aspects:
and clinical medicine, the journal welcomes articles from scientific areas Dandana, A.; Ben Khelifa, S.; Chahed, H.; Miled, A.; Ferchichi, S. (Sousse)
such as pathology, oncology, anatomy, virology, internal medicine, • Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell
surgery, cell and molecular biology, and immunology. Published bi- Machineries and Somatic Gene Mutations: Abe, H. (Tokyo); Kaneda, A.
(Chiba/Saitama); Fukayama, M. (Tokyo/ Saitama)
monthly, Pathobiology features original research papers and reviews on • Role of the Tumor Microenvironment in Breast Cancer: Soysal, S.D.;
translational research. The journal offers the possibility to publish pro- Tzankov, A.; Muenst, S.E. (Basel)
ceedings of meetings dedicated to one particular topic. • Frequency of TERT Promoter Mutations in Prostate Cancer: Stoehr, R.;
Taubert, H.; Zinnall, U.; Giedl, J. (Erlangen); Gaisa, N.T. (Aachen); Burger, M.;
Ruemmele, P. (Regensburg); Hurst, C.D.; Knowles, M.A. (Leeds); Wullich, B.;
Hartmann, A. (Erlangen)
• Calpain in Breast Cancer: Role in Disease Progression and Treatment
Response: Storr, S.J.; Thompson, N.; Pu, X.; Zhang, Y.; Martin, S.G.
(Nottingham)
• Tumour Heterogeneity of Breast Cancer: From Morphology to
Personalised Medicine: Aleskandarany, M.A. (Nottingham);
Pathobiology Vandenberghe, M.E. (Cambridge); Marchiò, C. (Turin); Ellis, I.O. (Nottingham);
Founded: 1938 Sapino, A. (Turin/Candiolo); Rakha, E.A. (Nottingham)
Category: Basic and Clinical Research • Genetic Profiling of Cancers of the Digestive System: Biological Insights
Field of Interest: Pathology and Clinical Implications: Stenzinger, A. (Heidelberg); Weichert, W. (Munich)
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2019: Volume 86
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Language: English
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